INTRODUCTION: Due to the skeletal workforce in the hospital during the COVID-19 pandemic, physicians are subject to great pressure, irregular work time, and frequent day-night work shifts, which may lead to the increase of sleep disturbances. OBJECTIVES: This was a single-center, cross-sectional, questionnaire-based study which aimed to (1) evaluate the quality of sleep and sleeping pattern of resident physicians in Makati Medical Center during the of COVID-19 Pandemic and (2) measure the association of sleep quality and sleep pattern with depression and anxiety. RESULTS: A total of 187 resident physicians were included in this study. 38.0% of participants had fair to poor sleep hygiene, 79.1% had short sleep pattern, and 74.9% had poor sleep quality. 44.4% of participants had probable anxiety and 47.6% had probable depression. Having probable anxiety (OR=5.1, 95% CI=2.3 to 11.4, p-value <0.001) and probable depression OR=2.6, 95% CI=1.3 to 5.2, p-value=0.006) were both significantly associated with poor sleep quality. CONCLUSION There is high prevalence of poor sleep quality among resident physicians in Makati Medical Center. In addition to this, almost half of the resident physicians show notable signs of anxiety and depression. Both sleep hygiene and sleep quality are significantly associated with risk for anxiety and depression.