2.Ischemic Lesion Water Uptake in Acute Stroke: Is Blood Glucose Related to Cause and Effect?
Gabriel BROOCKS ; Andre KEMMLING ; Jens ABERLE ; Helge KNIEP ; Matthias BECHSTEIN ; Fabian FLOTTMANN ; Hannes LEISCHNER ; Tobias D FAIZY ; Jawed NAWABI ; Gerhard SCHÖN ; Peter SPORNS ; Götz THOMALLA ; Jens FIEHLER ; Uta HANNING
Journal of Stroke 2019;21(3):347-349
No abstract available.
Blood Glucose
;
Stroke
;
Water
3.Venous Outflow Profiles Are Linked to Clinical Outcomes in Ischemic Stroke Patients with Extensive Baseline Infarct
Laurens WINKELMEIER ; Gabriel BROOCKS ; Helge KNIEP ; Vincent GEEST ; Jonathan REINWALD ; Lukas MEYER ; Noel VAN HORN ; Adrien GUENEGO ; Kamil ZELEŇÁK ; Gregory W. ALBERS ; Maarten LANSBERG ; Peter SPORNS ; Max WINTERMARK ; Jens FIEHLER ; Jeremy J. HEIT ; Tobias D. FAIZY
Journal of Stroke 2022;24(3):372-382
Background:
and Purpose The benefit of endovascular thrombectomy (EVT) treatment is still unclear in stroke patients presenting with extensive baseline infarct. The use of additional imaging biomarkers could improve clinical outcome prediction and individualized EVT selection in this vulnerable cohort. We hypothesized that cerebral venous outflow (VO) may be associated with functional outcomes in patients with low Alberta Stroke Program Early CT Score (ASPECTS).
Methods:
We conducted a retrospective multicenter cohort study of patients with acute ischemic stroke due to large vessel occlusion (AIS-LVO). Extensive baseline infarct was defined by an ASPECTS of ≤5 on admission computed tomography (CT). VO profiles were assessed on admission CT angiography using the Cortical Vein Opacification Score (COVES). Favorable VO was defined as COVES ≥3. Multivariable logistic regression was used to determine the association between cerebral VO and good clinical outcomes (90-day modified Rankin Scale score of ≤3).
Results:
A total of 98 patients met the inclusion criteria. Patients with extensive baseline infarct and favorable VO achieved significantly more often good clinical outcomes compared to patients with unfavorable VO (45.5% vs. 10.5%, P<0.001). Higher COVES were strongly associated with good clinical outcomes (odds ratio, 2.17; 95% confidence interval, 1.15 to 4.57; P=0.024), independent of ASPECTS, National Institutes of Health Stroke Scale, and success of EVT.
Conclusions
Cerebral VO profiles are associated with good clinical outcomes in AIS-LVO patients with extensive baseline infarct. VO profiles could serve as a useful additional imaging biomarker for treatment selection and outcome prediction in low ASPECTS patients.