No abstract available.
Skin Neoplasms* ; Skin*

No abstract available.
Folliculitis ; Herpes Zoster ; Herpesvirus 3, Human

No abstract available.
Cellulitis* ; Klebsiella pneumoniae* ; Klebsiella* ; Leg*

No abstract available.
Carcinoma, Adenoid Cystic* ; Histiocytoma, Benign Fibrous*

Keratinocyte-fibroblast interactions are critical for skin repair after injury. During the proliferative phase of wound healing, proliferation, migration and differentiation of these cells are the major mechanisms leading to tissue remodeling. We have previously reported that glycitin, a major soy isoflavone, stimulates dermal fibroblast proliferation; and the phytochemical, 4′,6,7-trimethoxyisoflavone (TMF), induces migration of HaCaT keratinocyte cells. We therefore investigated whether these compounds display synergistic effects on skin cells during wound healing in vitro and in vivo. Co-treatment with TMF and glycitin synergistically promotes the proliferation and migration of both keratinocytes and dermal fibroblasts, with a 1:1 ratio of these compounds showing the greatest efficacy in our co-culture system. This keratinocyte-fibroblast interaction occurred via the secretion of TGF-β, and the induction of differentiation and proliferation was confirmed in both indirect and direct co-culture assays. In an excisional and burn wound animal model, mice treated with a 1:1 ratio of TMF and glycitin showed faster wound closure, regeneration and scar reduction than even the positive control drug. These data indicate that two isoflavones, TMF and glycitin, act synergistically to promote wound healing and anti-scarring and could potentially be developed together as a bioactive therapeutic for wound treatment.
Animals ; Burns ; Cicatrix ; Coculture Techniques ; Fibroblasts* ; In Vitro Techniques ; Isoflavones ; Keratinocytes* ; Mice ; Models, Animal ; Regeneration ; Skin ; Wound Healing* ; Wounds and Injuries*

No abstract available.
Anaphylaxis* ; Basophils*

Macrodactyly of the toe is a rare congenital anomaly characterized by the overgrowth of a digit/digits in the foot and is one of the most difficult conditions to treat. Since the condition alters functionality and appearance, the treatment goal is to restore function and cosmetically enhance the appearance. Various surgical techniques are used for toe macrodactyly, including amputation, debulking, and epiphysiodesis. Herein, we present a case of a six-year-old patient with a second toe macrodactyly who was successfully treated with a twostage operation over a seven-year period. We initially performed an ostectomy of the middle phalanx with a fusion of the proximal and distal phalanges and then performed a soft tissue debulking procedure.

No abstract available.
Herpes Zoster* ; Urinary Retention*

No abstract available.
Lipomatosis* ; Neoplasm Metastasis* ; Small Cell Lung Carcinoma*

BACKGROUND: Keloids and hypertrophic scars (HTS) are chronic disfiguring dermatoses and can cause functional impairment and psychosocial burdens, both of which affect quality of life. OBJECTIVE: Our purpose of this study was to compare the quality of life using the Dermatology Life Quality Index (DLQI) scores in patients with keloids and HTS to those of normal controls. METHODS: A total 31 patients with keloids and HTS attending our dermatology outpatient clinic as well as 30 healthy controls completed the DLQI. The relationship between quality of life and clinical characteristics of patients with keloids and HTS was investigated using the Vancouver Scar Scale (VSS). RESULTS: Total average DLQI scores of patients with keloids and HTS (mean 5.48+/-6.23) were significantly higher than those of healthy controls (mean 2.43+/-3.96) (p<0.05). There was a significant positive relationship between the DLQI and the VSS in patients with keloids and HTS (r=0.372, p=0.040). Pliability (r=0.416, p=0.020) and height (r=0.496, p=0.005) independently showed a positive association with the DLQI. There was no association between the DLQI and the duration and location of keloids and HTS. CONCLUSION: In our study, the quality of life of patients with keloids and HTS was impaired and poorer than that of the healthy controls.
Ambulatory Care Facilities ; Cicatrix ; Cicatrix, Hypertrophic* ; Dermatology ; Humans ; Keloid* ; Pliability ; Quality of Life* ; Skin Diseases