Background: Globally, YouTube is one of the most popular websites, and the content is not restricted to entertainment. The purpose of this study was to assess the quality of information in YouTube videos pertaining to hysterectomy. Methods: We explored YouTube using the search terms “hysterectomy” and “remove uterus.” The videos that appeared were sorted using the filter “sort by view count.” Of the initial 100 videos, the top 50 videos for each search term were included for review, as determined by the “relevance” filter based on YouTube's algorithm. After excluding 34 videos for various reasons, 66 were included in the final analysis. Each video rated as “useful” was further analyzed for reliability and completeness of information; a set of pre-determined criteria were modified from a previous study and used to grade the quality of videos. Results: The top 66 videos on hysterectomy had a total of 4,679,118 views. Based on authorship, the videos were categorized as follows: videos uploaded by patients, 37%; academic videos, 35%; videos uploaded by physicians, 13%; commercial videos, 4%; and videos uploaded by non-physicians, 2%. The type of content was also categorized: 50% of the videos recorded personal experiences, 23% recorded surgical techniques, 21% involved explanations of the surgery, and 4% were commercial videos. The majority of the videos made by patients were negatively biased toward hysterectomy surgery (71.72%), while the majority of those made by academics or physicians were surgical educational videos for doctors, not patients. Conclusion YouTube is currently not an appropriate source for patients to gain information on hysterectomy. Physicians should be aware of the limitations and provide up-to-date and peer-reviewed content on the website.

Non-Hodgkin's lymphoma presented as a malignancy of the uterine cervix is exceedingly rare disease and accounts for approximately only 0.12-0.6% of extranodal lymphomas. Most reported cases were B-cell lymphomas and there is no consensus on the management and prognosis of the disease because of its extreme rarity. Primary T/natural killer (NK)-cell lymphoma arising from the uterine cervix is scarcely encountered that, in the review of literature, only 1 case has been reported by Mhawech et al. We encountered a woman with T/NK-cell lymphoma involving the uterine cervix that initially presented with severe vaginal bleeding. Therefore, we report the case with a brief review of literature.
Cervix Uteri* ; Consensus ; Female ; Humans ; Lymphoma* ; Lymphoma, B-Cell ; Lymphoma, Non-Hodgkin ; Prognosis ; Rare Diseases ; Uterine Hemorrhage

Drug Information Centers are responsible for providing updated, relevant drug information on the efficacy, safety and quality of drugs as well as disease status to health-care practitioners and finally to patients. This study was designed to revise the drug information service based on the evaluation to meet the social requirement that is created by the recent "Drug Prescription and Dispensing Law" A retrospective analysis was conducted from April 1997 untill September 2000. To evaluate the trend of service, the evaluated period was divided in 7 6-months intervals. The feedback system was used to measure the satisfaction score as an outcome. Out of 618 total enquiries, 192 (31.0%) was received in the last 6-month period. The method of receiving and providing drug information by Drug Information Research Institute (DIRI) gradually changed from telephone calls to e-mailing system (2.2% vs. 67.2% in question, 2.2% vs. 70.3% in answer). Drug information questions concerning the pharmacology (18.8%), adverse drug reaction (10.5%), availability (10.3%) and drug interaction (5.2%) were asked most frequently. The median time to respond the inquired questions was 24 hours (range: 1 hr-8 days). The reference used most frequently to answer was the tertiary literature (42.0%) followed by the second literature (27%) and primary literature (7%). The evaluable 29 feedbacks showed that DI services provided by DIRI were satisfactory in accuracy and time. On the basis of the analysis and evaluation of this project, DIRI have developed the more specified Q and A Sheet Form, systemic database and on-line Q and A corner accessible through the homepage.
Academies and Institutes ; Drug Information Services* ; Drug Interactions ; Drug-Related Side Effects and Adverse Reactions ; Electronic Mail ; Humans ; Information Centers* ; Pharmacology ; Prescriptions ; Retrospective Studies ; Telephone

OBJECTIVE: To assess the role of preoperative and postoperative serum C-reactive protein (CRP) level on the prediction of pregnancy outcomes following ultrasound-indicated cerclage (UIC). METHODS: We retrospectively reviewed the medical records 44 women who underwent UIC between January 2011 and December 2011. UIC was performed between 14 and 24 weeks of gestation in women with short cervix. We divided UIC patients into two groups according to the gestational age at delivery (34 weeks) and compared the two groups. Group A was defined as patients who delivered ≥34 weeks of gestation, and group B as patients delivered <34 weeks. Correlation and receiver-operating characteristic curves were also analyzed for the prediction of preterm birth after UIC. RESULTS: Thirty women delivered ≥34 weeks (group A) and 14 women delivered <34 weeks (group B). Pre- and post-cerclage CRP were significantly lower in group A (pre-cerclage CRP, 1.1±1.0 vs. 11.4±6.2 mg/dL, P<0.001; post-cerclage CRP, 0.6±0.5 vs. 7.4±7.2 mg/dL, P<0.001). The mean gestational age at delivery in group A was 37.7±1.8 weeks and that in group B was 26.9±4.3 weeks (P<0.001). There were significant negative correlations between pre- and post-cerclage CRP and latency from UIC to delivery (r=-0.82, P<0.001; r=-0.70, P<0.001, respectively). CONCLUSION: Both pre- and post-cerclage CRP were useful in predicting the preterm birth following UIC.
C-Reactive Protein* ; Cervix Uteri ; Female ; Gestational Age ; Humans ; Medical Records ; Pregnancy ; Pregnancy Outcome ; Premature Birth ; Retrospective Studies

OBJECTIVE: The aim of this study was to assess the regression rate of the mild cervical dysplasia and to examine the factors associated with the regression. METHODS: One hundred and nine women pathologically confirmed with mild cervical dysplasia were recruited into this study. They were followed up by cytology, colposcopy and human papillomavirus DNA test at 3 months and 6 months after the diagnosis. The participants filled out a questionnaire on their demographic characteristics and sexual history. RESULTS: The rate of spontaneous regression for the mild cervical dysplasia was 59.6%(65/109). Multivariate analysis showed that initial ASCUS cytology, negative HPV status, non-smoker, condom user and age under 40 years old were associated with higher regression rate. CONCLUSIONS: The rate of regression for mild cervical dysplasia seen in our study was particularly higher than the result in previous study. Therefore, we recommend that the patients with mild cervical dysplasia can be followed up by cytology and HPV DNA study without any intervention, especially in young patients. Initial ASCUS cytology, negative HPV status, non-smoker, condom user and age under 40 years old were good related factors for regression.
Adult ; Colposcopy ; Condoms ; Diagnosis ; DNA ; Female ; Humans ; Multivariate Analysis ; Surveys and Questionnaire

Leucine-rich repeat kinase 2 (LRRK2) is a gene that, upon mutation, causes autosomal-dominant familial Parkinson's disease (PD). Yeast two-hybrid screening revealed that Snapin, a SNAP-25 (synaptosomal-associated protein-25) interacting protein, interacts with LRRK2. An in vitro kinase assay exhibited that Snapin is phosphorylated by LRRK2. A glutathione-S-transferase (GST) pull-down assay showed that LRRK2 may interact with Snapin via its Ras-of-complex (ROC) and N-terminal domains, with no significant difference on interaction of Snapin with LRRK2 wild type (WT) or its pathogenic mutants. Further analysis by mutation study revealed that Threonine 117 of Snapin is one of the sites phosphorylated by LRRK2. Furthermore, a Snapin T117D phosphomimetic mutant decreased its interaction with SNAP-25 in the GST pull-down assay. SNAP-25 is a component of the SNARE (Soluble NSF Attachment protein REceptor) complex and is critical for the exocytosis of synaptic vesicles. Incubation of rat brain lysate with recombinant Snapin T117D, but not WT, protein caused decreased interaction of synaptotagmin with the SNARE complex based on a co-immunoprecipitation assay. We further found that LRRK2-dependent phosphorylation of Snapin in the hippocampal neurons resulted in a decrease in the number of readily releasable vesicles and the extent of exocytotic release. Combined, these data suggest that LRRK2 may regulate neurotransmitter release via control of Snapin function by inhibitory phosphorylation.
Amino Acid Sequence ; Animals ; Exocytosis ; Female ; HEK293 Cells ; Humans ; Mice ; Molecular Sequence Data ; Mutant Proteins/metabolism ; Phosphorylation ; Phosphothreonine/metabolism ; Protein Binding ; Protein Interaction Mapping ; Protein Structure, Tertiary ; Protein-Serine-Threonine Kinases/*metabolism ; Qa-SNARE Proteins/metabolism ; Rats ; Rats, Sprague-Dawley ; Synaptosomal-Associated Protein 25/*metabolism ; Synaptotagmins/metabolism ; Vesicle-Associated Membrane Protein 2/metabolism ; Vesicular Transport Proteins/chemistry/*metabolism

OBJECTIVE: To assess the association between platinum-based chemotherapy for gynecologic malignancy and the risk of diabetes mellitus. MATERIAL AND METHODS: We analyzed retrospectively the association between platinum-based chemotherapy and diabetes mellitus. Out of the 449 patients who received the chemotherapy in Severance Hospital from January 2002 to December 2005, 169 patients with serial measurements of fasting blood glucose throughout the chemotherapy period were enrolled in this study. The parameters that were analyzed included age, past history, family history, body mass index (BMI), serum glucose, type of cancer, chemotherapy regimen, dose cycle, time after cycle. We performed binomial test to compare the incidence in our patients with that of general population. RESULTS: In 8 patients (4.8%) diabetes mellitus developed during the treatment period. The median age of patients was 57 years, and the mean BMI was 27.0 kg/m2. All patients received platinum-based chemotherapy and seven of them received cisplatin based regimen and two patient was given carboplatin based regimen. Median cisplatin cumulative dose up until the diabetes mellitus occurred was 252 mg/m2 and that of carboplatin was 812 mg/m2. Median time until the diagnosis of diabetes mellitus after administration of the first chemotherapy cycle was 7 months. The overall incidence of hyperglycemia (4.8%) in patients treated with platinum-based chemotherapy is higher than the incidence of diabetes mellitus in the general population (2.1%). CONCLUSION: We suggest that regular monitoring of serum glucose levels which is not generally included in the pre-chemo lab values in patients receiving chemotherapy with platinum based regimen should be considered.
Blood Glucose ; Body Mass Index ; Carboplatin ; Cisplatin ; Diabetes Mellitus ; Fasting ; Glucose ; Humans ; Hyperglycemia ; Incidence ; Platinum ; Pyridines ; Retrospective Studies ; Thiazoles

Pulmonary sequestration is a developmental anomaly of broncho-pulmonary foregut with nonfunctioning parenchymal tissue, which usually supplied by systemic circulation. Pulmonary sequestration is detected by ultrasonography as a homogeneous echogenic mass and also by Doppler blood flow from systemic circulation to the mass. Pulmonary sequestration is classified into intralobar type and extralobar type. Extralobar type accounts for only 15~25% of the cases and it is subdivided into intrathoracic forms, which are most commonly found and extrathoracic type, which includes intraabdominal, retroperitoneal, or mediastinal masses. We report a rare case of prenatal detection of mediastinal mass with a brief review of literatures, which was confirmed to be a pulmonary sequestration by surgical mass excision after birth.
Bronchopulmonary Sequestration ; Parturition ; Ultrasonography, Prenatal

Estimated incidence of round ligament varicosities in pregnancy is not known and often times it is confused with inguinal hernia due to their clinical similarities. When a patient is presented with inguinal mass especially in association with varicosity in the genital region or lower extremity, round ligament varicosity must be considered as a plausible diagnosis. Depiction of "bag of worms" on color Doppler ultrasonography is diagnostic of the round ligament varicosity and it is known to resolve spontaneously following delivery. We report a case of round ligament varicosities that was diagnosed at 29 weeks of gestation with a brief review of the literatures.
Hernia, Inguinal ; Humans ; Incidence ; Lower Extremity ; Pregnancy ; Round Ligament of Uterus ; Ultrasonography, Doppler, Color

OBJECTIVE: Our hospital's policy is to perform history-indicated cerclage (HIC) for pregnant patients with 1 or more second-trimester pregnancy losses. Recently, the American College of Obstetricians and Gynecologists (ACOG) guideline regarding indications for HIC was changed from 3 or more previous second-trimester fetal losses to one or more. In this study, we aimed to evaluate the efficacy of the revised guideline and to investigate the association between previous preterm history and cerclage outcome. METHODS: We conducted a retrospective observational study of cases of HIC in singleton pregnancies performed at our hospital between January 2007 and June 2016. We compared the perioperative complications and incidences of preterm delivery in patients with one previous second-trimester pregnancy loss against those in patients with ≥2 losses. RESULTS: The incidence of preterm delivery (< 32 weeks) was significantly lower in patients with one previous second-trimester pregnancy loss than in those with ≥2 losses (15/194 [8%] vs. 28/205 [14%]). In the 1 loss and ≥2 losses groups, the rates of preterm premature rupture of membranes (PPROM) were 7% and 8%, the rates of PPROM at < 32 weeks 2.1% and 3.4%, and the ratios of neonatal intensive care unit admission 10% and 17%, respectively. CONCLUSION: Comparison of HIC in one previous second-trimester pregnancy loss group with HIC in the 2 or more previous second-trimester pregnancy loss group found no difference in pregnancy outcome. This finding supports the amended ACOG guideline for HIC indications. Based on our results, we also propose development of a new protocol for HIC-related complications.
Cerclage, Cervical ; Female ; Humans ; Incidence ; Infant, Newborn ; Intensive Care, Neonatal ; Membranes ; Observational Study ; Pregnancy ; Pregnancy Outcome ; Premature Birth ; Retrospective Studies ; Rupture ; Uterine Cervical Incompetence