OBJECTIVE:To study the general layout on the quality control of clinical pharmacy work of Xuzhou city during the period of2005～2008.METHODS:The problems appeared in hospital clinical pharmacy were analyzed by adopting ISO9001process control theory,i.e.PDAC cyclical quality management method,and suggestions on the corresponding scheme and practices were raised.RESULTS&CONCLUSIONS:Studying the general layout on the quality control of clinical pharmacy work by means of ISO9001process control theory is conducive to the development of clinical pharmacy of Xuzhou city.

OBJECTIVE:To probe into the standardized administration in the public bid for drug purchase of medical institutions.METHODS:Experiences and understandings in carrying out ISO9001standards in the public bid for drug purchase of our hospital were introduced;problems involved in which were analyzed and some advices were put forward.RESULTS&CONCLUSION:The practice of ISO9001standards does good to the consummation and standardization of the public bid of drug purchase in Chinese medical institutions.

Burns ; complications ; metabolism ; Endotoxemia ; etiology ; metabolism ; Humans ; Multiple Organ Failure ; etiology ; metabolism ; Myocytes, Cardiac ; metabolism

Blood Glucose ; analysis ; Diabetes Complications ; prevention & control ; Diabetes Mellitus, Type 2 ; blood ; therapy ; Humans ; Risk Factors

Objective To assess the impact of parents' occupational class and intergenerational occupational mobility on children's mental health so as to provide evidence for improving health equity.Methods Chinese general social survey 2005 (CGSS2005) dataset was used for multivariate analysis of variance (MANOVA).Results The proportion of children whose father or mother was of lowerclass occupation was 59.0％ and 62.9％,respectively.When grew up,this figure dropped to 49.8％.Those whose father was in the higher-class occupational group reported better mental health status (F =1.449,P=0.015).Downward occupational class mobility experience also increased the risk of mental illness (F =3.050,P =0.048).Conclusion This study suggests an independent relationship between mental health and parents' occupational class and intergenerational occupational mobility.

Objective:To investigate the consistency of two methods in the measurement of bone mineral density in the lateral lumbar vertebra.Methods:The bone mineral densities of the 2nd,3rd and 4th lumbar vertebras in 18 female patients,at a preset side lying position,were measured respectively by two methods(lateral spine analysis,LS and lateral vertebral analysis,LVA) provided by the dual-energy(X-ray) absorptiometry(GE Lunar,Prodigy).The results were recorded and analyzed by SPSS(Version(10.0).) The values of bone mineral density were displayed by boxplot,paired and analyzed by(Wilcoxon's) signed rank test and(Pearson's) correlation analysis.Statistical significance was considered when P(0.05),) and were clearly correlated(P

AIM: To establish the technique of precision-cut fibrotic liver slice (PCLS) and grope the optimal cultural conditions for researching the liver xenobiotic metabolism in vitro and the drug interaction. METHODS: Complex factors (higher fat diet, alcohol and CCl 4) were used to make the animal model of liver fibrosis. Fibrotic liver slices were prepared and cultivation system was established. Lactate dehydrogenase (LDH) leakage, glutathione S-transferase (GST) activity and 3[4,5-Dimethythiazole-2-yl]-2,5- diphenyltetrazolium bromide (MTT) reduction were chosen as indexes to assess the viability of the slice in different thickness, medium pH and cultural time. RESULTS: Rats were in earlier hepatic fibrosis after administration for 3 weeks. When the thickness of slices was 300 ?m and medium pH was 7.0, the LDH leakage, GST activity and MTT reduction could maintain on a steady level in 6 h. CONCLUSION: A 300 ?m of thickness, 7.0 of medium pH and 6 h of cultural time are the optimal slicing and culturing conditions for fibrotic liver slice.

OBJECTIVE:To study the isolation of lentinan,the average molecular weight of which ranged within400000to600000.METHODS:The fine lentinan was purified by2—diethyllaminoethyl—cellulose anion exchange column chro-matography,which was then isolated by dextran gel G-200column chromatography with the molecular weights determined by high performance gel chromatography.RESULTS:The average molecule weight of the isolated lentinan ranged from400000to600000.CONCLUSION:This method can be used for the isolation of lentinan.

OBJECTIVE:To probe into the relation between integrated pharmaceutical care and the drug use administration of inpatients with medical insurance.METHODS:The principle and the role of the integrated pharmaceutical care were in?troduced;and the problems in the drug use administration of inpatients with medical insurance were analyzed and some sug?gestions were put forward accordingly.RESULTS&CONCLUSION:The key in drug use administration of inpatients with medical insurance is to implement integrated pharmaceutical care in accordance with clinical pharmacy practice program and to keep the medical expenditures under control by means of principles and methods in pharmacoeconomics.

To prepare and study the pharmacokinetics and release bioavailability in olunteers and concentrations in plasma in patients. METHODS: Ethylcellulose was used matrix in phase separation-coacervation for preparation of microencapsulation. The release experiments were performed in a rotating shaker. The isoniazid concentration in plasma was determined by spectrophotometrical method following a single oral dose of sustained-release cupsule and ordinary tablet respectively given to 10 volunteers in a open randomized cross-over test. MCP86 was used to process main pharmacokinetic parameters. RESULTS: The sustained-release of capsule and ordinary teblet in vitro, T50 was 1 h and 0.032 h respectively. The drug in sustained-release capsule was sustained release over 10 h. The main parameters in body: ordinary tablets: cmax=11.12 μgml-1, tmax=1.41 h, K=0.201 h-1; sustained release capsule: cmax=4.99 μgml-1, tmax=1.80 h, K=0.03 h-1. The concentration of blood at 36 h was (0±0)μgml-1 and 1.63 μgml-1 respectively. Except tmax, there was significant difference between the two fomulations (P＜0.01). The concentration of blood in patient at 1.5 h and 36 h. ordinary tablet and sustained-release capsule respectively were (8.24±2.60)μgml-1, (0±0)μgml-1and (3.69±0.86)μgml-1, (2.09±0.56)μgml-1. CONCLUSION: The sustained-release capsule will play an important part in prevention and treatment of tuberculosis as the result of its reasonable formulation and simple technology.