Objective:To explore the genotype and allele distribution feature of cytochrome P450 2C19 (CYP2C19) in Uighur and Han nationality patients With coronary heart disease (CHD).Methods:A total of 355 CHD patients Without kinship,including 194 Uighur cases and 161 Han cases,Were selected. CYP2C19 genetic polymorphism Was analyzed using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP),it’ s compared betWeen different age groups (<60 years and≥60 years)of the tWo nationalities.Results:Compared With Han na-tionality patients,there Were significant increase in allele*1 frequency [(64.9% vs.75.2%),P<0.01],signifi-cant decrease in allele*2 (29.5% vs.22.2%),and allele*3 (5.6% vs.2.6%) frequencies (P<0.05 all);geno-type*1/*1 significant increase [(38.5% vs. 57.7%),P<0.01],*1/*2 significant decrease [(44.7% vs. 31.5%),P<0.05],and other four genotype betWeen tWo nationalities Were no significant difference (P>0.05);fast metabolic patter frequency (38.5% vs. 57.7%)significant increase,moderate metabolic patter frequency (52.8% vs. 31.5%)significant decrease (P<0.01 all)in Uighur nationality patients ;In a same nationality,age had no significant impact on its genotype and allele distribution (P>0.05 all).Conclusion:There are significant differences in cytochrome P450 2C19 genotype and allele distribution betWeen Uighur nationality and Han nationali-ty CHD patients,Understanding those is of important significance to guide clinical medication and improve patients' prognosis.

The Establishment and improvement of the scientific research incentive mechanism is the key to optimize the internal management, improve the performance, enhance the core competitiveness of the hospital.Research time and energy is limited because University Affiliated Hospital Medical Staff are in charge of medical treatment, teaching and scientific research.It's very important to mobilize the scientific research enthusiasm of the medical staff by using the scientific research incentive mechanism and promote the scientific research strength of hospital.This paper introduced the scientific research incentive mechanism and the achievements in the Second Affiliated Hospital of The Xinjiang Medical University.The exploration and thinking on the results and the existing problems are proposed in the paper.

Objective To study central obesity among middle-aged and elderly residents of Xinjiang Uygur and Han ethnicities, living in rural and urban areas. Methods Multi-stage stratified random cluster sampling approaches were adopted to collect data from 6 areas in Soutbem, Eastern, Northern Xinjiang and Urumqi city community, from July of 2005 to June of 2007. Results 8284 people were investigated to have found that the crude prevalence rate and the adjusted standardized incidence were 50.11% and 55.40% respectively, on central obesity. The figures were higher than the national level, according to the 2000 census age composition of Xinjiang. The prevalence rate of central obesity was higher in males than in females (P<0.05) higher in residents of Uygur than in Han ethnicities(P<0.05). The prevalent rates of the central obesity hypertension, diabetes and dyslipidemia were higher than those of non-obese ones (P<0.05). Conclusion The standardized prevalence rates of central obesity in residents with Xinjiang Uygur and Hart ethnicities were higher than data from the national statistics. Differences were found in ethnicity, gender and age. The prevalence rates of hypertension, diabetes and dyslipidemia in people having central obesity were higher than the non-obese ones.

Objective By comparing the efficacy and toxicity of three extraction methods of Gegen Qinlian formula,so as to underline the appropriate technology of its extraction and preparation.Methods Mice were divided into blank group,pathological group,tablet group,pill group and decoction group, in which the latter three groups were divided into high -,mid -and low -dose subgroups respectively. The mice models were induced by i.g.senna decoction 20 mL/kg(4 g/kg).The tablet group were i.g. extract water solution at dose of 1.60,0.80,0.40 g/kg,the pill group were i.g.at dose of 6,3 and 1.5 g/kg,and the decoction group at dose of 13,6.5 and 3.25 g/kg.The number of the wet dung was chosen to evaluate the antidiarrheic effect of Gegen Qinlian formula.Then the acute toxicity test of differ-ent samples was carried out through maximal dosage experiments.Mice were divided into tablet group, pill group and decoction group,with 10 mice in each group.And the maximum dosage were 0.66 g/mL (tablet),0.63 g/mL(pill)and 0.74 g/mL(decoction),equivalent to crude drug pieces of 67.96, 89.01 and 177.77 g/kg,and equivalent to 24,9 and 6 times daily dose of per kilogram of body weight of 70 kg.After the single dose administration,the reactions of the mice were observed for consecutive seven days.Results The sample of three dosage forms of Gegen Qinlian formula had obvious therapeutic effect (P <0.001),among which the antidiarrheic effect of tablets was best (P <0.05),pill less and decoc-tion least.No death or obvious abnormalities was discovered under maximum dosage.Conclusion In the three preparations,Gegen Qinlian tablets extraction preparation method recorded in 2015 Chinese Pharmacopoeia had the best inhibitory effect against diarrhea caused by senna leaves.

To investigate the potential role of transforming growth factor (TGF)-β1 in liver fibrosis during Echinococcus granulosus infection, 96 BALB/c mice were randomly divided into 2 groups, experimental group infected by intraperitoneal injection with a metacestode suspension and control group given sterile physiological saline. The liver and blood samples were collected at days 2, 8, 30, 90, 180, and 270 post infection (PI), and the expression of TGF-β1 mRNA and protein was determined by real-time quantitative RT-PCR and ELISA, respectively. We also evaluated the pathological changes in the liver during the infection using hematoxylin and eosin (H-E) and Masson staining of the liver sections. Pathological analysis of H-E stained infected liver sections revealed liver cell edema, bile duct proliferation, and structural damages of the liver as evidenced by not clearly visible lobular architecture of the infected liver, degeneration of liver cell vacuoles, and infiltration of lymphocytes at late stages of infection. The liver tissue sections from control mice remained normal. Masson staining showed worsening of liver fibrosis at the end stages of the infection. The levels of TGF-β1 did not show significant changes at the early stages of infection, but there were significant increases in the levels of TGF-β1 at the middle and late stages of infection (P<0.05). RT-PCR results showed that, when compared with the control group, TGF-β1 mRNA was low and comparable with that in control mice at the early stages of infection, and that it was significantly increased at day 30 PI and remained at high levels until day 270 PI (P<0.05). The results of this study suggested that increased expression of TGF-β1 during E. granulosus infection may play a significant role in liver fibrosis associated with E. granulosus infection.
Animals ; Bile Ducts ; Echinococcus granulosus* ; Echinococcus* ; Edema ; Enzyme-Linked Immunosorbent Assay ; Eosine Yellowish-(YS) ; Hematoxylin ; Injections, Intraperitoneal ; Liver Cirrhosis* ; Liver* ; Lymphocytes ; Mice* ; RNA, Messenger ; Transforming Growth Factors ; Vacuoles