This article analyzed the ethical situation in hospitals. The author pointed out the defect of confidence between doctor and patient is the primary cause that leaded to the deterioration of doctor-patient relation, and the retardation of medical service management is the important factor that affected the confidence construction. According to all this above, the author proposed the suggestion of strengthening the understanding and communication between doctor and patient, transforming the medical service concept, enhancing the medical service quality, completing the supervising system, increasing the hospital ability of realizing medical service defect and improving the five thoughts of follow up confidence system to direct the hospital confidence ethical construction.

Angiotensin II (ANGII) plays an important role in the pathogenesis of atherosclerosis by inducing proliferation of vascular smooth muscle cells (VSMCs). In our study, we observed the effects of valsartan on proliferation of cultured VSMCs treated with or without ANGII by cell counting and methyl thiazolyl tetrazolium (MTT) assay, and detected the expression of mitofusin 2 (Mfn2), a newly discovered cell proliferation inhibitor and a related cell proliferation signaling pathway protein by Western blotting. ANGII at a concentration of 10(-6) mol/L significantly stimulated VSMCs proliferation, down-regulated the expression of Mfn2 and up-regulated the expression of Raf and ERK1/2. Valsartan inhibited such effects of ANGII at concentrations of 10(-5) and 10(-6) mol/L, but not at 10(-7) mol/L. Valsartan had no significant effect on the proliferation of untreated VSMCs. These results suggest that valsartan inhibits ANGII-induced proliferation of VSMCs in vitro via Mfn2-Ras-Raf-ERK/MAPK signaling pathway.

Metaphors serve as important linguistic tools in doctor-patient communication， especially in describing and elucidating medical conditions to patients. Metaphors are widely used in doctor-patient communication because they represent complex medical terminology and diagnostic information in a more vivid and comprehensible way， which allows patients to understand and accept what doctors intend to convey. Also， doctors use metaphors to alleviate patients’ fear and anxiety， thus enhancing trust and cooperation between them. However， it is noted that some challenges should be considered. In other words， the misuse of metaphors may cause misunderstandings， which could compromise the effectiveness of treatments. In this context， the proper use of metaphors is a significant issue in linguistics and communication studies. The development of philosophy of language not only offers various approaches to account for metaphors but also raises some issues in how doctors and patients understand metaphors. One point relates to the indeterminacy of metaphors， which means a single metaphor could have multiple interpretations. If this occurs， a patient may become confused when a doctor utters a metaphor. Another point involves the presuppositions in metaphors， which emphasize the implicit assumptions or background knowledge that a metaphor relies on for its interpretation. These presuppositions influence how a patient understands a metaphor. If the patient does not share the same presuppositions as the doctor， they may misunderstand what the doctor intends to convey. The aim of this paper is to address the challenges of metaphor use in doctor-patient communication through theoretical analysis， thereby fostering harmonious doctor-patient relationships and improving the quality and effectiveness of healthcare services.

Angiotensin Ⅱ (ANG Ⅱ) plays an important role in the pathogenesis of atherosclerosis by inducing proliferation of vascular smooth muscle cells (VSMCs).In our study,we observed the effects of valsartan on proliferation of cultured VSMCs treated with or without ANG Ⅱ by cell count ing and methyl thiazolyl tetrazolium (MTT) assay,and detected the expression of mitofusin 2 (Mfn2),a newly discovered cell proliferation inhibitor and a related cell proliferation signaling pathway protein by Western blotting.ANGⅡ at a concentration of 10-6 mol/L significantly stimulated VSMCs proliferation,down-regulated the expression of Mfn2 and up-regulated the expression of Raf and ERK1/2.Valsartan inhibited such effects of ANG Ⅱ at concentrations of 10-5 and 10-6 mol/L,but not at 10-7 mol/L.Valsartan had no significant effect on the proliferation of untreated VSMCs.These results suggest that valsartan inhibits ANGⅡ-induced proliferation of VSMCs in vitro via Mfn2-Ras-Raf-ERK/MAPK signaling pathway.