T cell can be divided into theophylline sensitive cell (TS) and theophylline resistant cell (TR) based on the E-RFC using human peripheral T cell treated with theophylline. The TS may be regarded as suppressor T cell and the TR helper T cell. T cell subsets were enumerated in 45 cases of Graves' disease(GD) and 22 normal controls. The results showed that the TR was significantly higher (56.63+7.03%) while the TS was.much lower (15.07+3.78%) in the patients than those in the controls (41.84+4.77% and 26.45+4.45% respectively). The TR/TS ratio of the pateints was elevated (4.16 + 1.76 vs 1.61 + 0.33) .The patients with normal serum T3, T4 after treatment of anti-thyroid drugs could be divided into-two subgroups, one with high and another with normal TR / TS ratio. TS function was determined using the mixed lymphocyte culture and the results were expressed as the suppressive rate (SR). The SR of the patients was singificantly lower than that of the controls (17.88 +2.52% vs 39.56 +3.22%). A positive correlation was found between the serum T3, T4 and TR / TS ratio of the patients. Our findings indicated that patients with GD may have immunological abnormalities in quantity and function of TS and the disturbance of immunoregulation might exist in Graves' disease.

It is plentiful about the 289 abstracts for the colorectal cancer (CRC) in the 2017 annual meeting of the American Society of Clinical Oncology (ASCO),which include:(1) comparison between long and short courses of postoperative adjuvant chemotherapy for stage Ⅲ CRC in the early diseases,applications of the full course of neoadjuvant therapy for locally advanced rectal cancer and laparoscopic total mesorectal excision for rectal cancer.(2) The use of Vitamin D3 and selective interstitial radiotherapy for metastatic CRC in the advanced diseases showed an encouraging efficacy.Patients with BRAF mutation and poor prognosis underwent a combination therapy of BRAF inhibitor and epidermal growth factor receptor (EGFR),which has created a new situation for precision therapy.And China's domestically designed Fruquintinib (small-molecule kinase inhibitor) and EGFR CMABO09 have showed better clinical efficacies in the second-line therapy.(3) On the precision medicine and translational researches,clinical value of consensus of molecular subtypes is being revealed and liquid biopsy is advantageous to predict postoperative tumor recurrence.These new therapies and researches would impact the clinical practices,promote clinical development and benefit the patients.

Objective To evaluate the effect of dexmedetomidine sedation on acute lung injury induced by trauma and endotoxemia two-hit in rats.Methods Twenty-four adult male Sprague-Dawley rats,aged 6-8 weeks,weighing 150-200 g,were randomized into 3 groups (n =8 each) using a random number table:control group (group C),two-hit group (group T) and dexmedetomidine group (group D).Bilateral middle femoral shaft fractures were produced using hemostatic forceps.In group D,dexmedetomidine 2.5 tμg· kg-1· h-1 was infused via the caudal vein immediately after fractures,while the equal volume of normal saline was infused for 8 h in C and T groups.Lipopolysaccharide 2.5 mg/kg was injected via the caudal vein at 4 h after fractures in T and D groups.All the animals were monitored for 24 h with a continuous glucose monitoring system.Blood glucose concentrations were recorded within 24 h after fractures,and mean amplitude of glucose excursions (MAGE) was calculated.The arterial blood samples were collected at 24 h after fractures for blood gas analysis.The lungs were then harvested for determination of tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) contents in lung tissues and for microscopic examination of pathological changes which were scored.Results Compared with group C,MAGE,PaCO2,TNF-α and IL-6 contents and pathological scores were significantly increased,and pH value and PaO2 were decreased in T and D groups.Compared with group T,MAGE,TNF-α and IL-6 contents and pathological scores were significantly decreased,and pH value and PaO2 were increased,and no significant change was found in PaCO2 in D group.Conclusion Dexmedetomidine sedation can mitigate acute lung injury induced by trauma and endotoxemia two-hit,and the mechanism is related to reduced stress and inflammatory responses in rats.

Objective To explore the relevant factors of macrosomia in order to own better antepartum prevention and obsterical measure.Methods Retrospective analysis was conducted in the total of 349 complete macrosomia cases in this hospital,the relevant factors of macrosornia( except diabetes melitus) were compare and analyzeed.Results There was significant correlation between macrosomia and age of pregnant woman,gestional weeks,body mass index.Conclusion In order to reduce the incidence rate of macmsomia,decrease the rate of uterine-recision delivery and save the life for the mother and the infant,some effective measures should be carried out for pregnant ladies who are foreseen to have a macrosomia.

Objective To explore the effect of μ-opioid receptor agonist on acute lung injury in-duced by trauma-LPS two hits in rat model.Methods Thirty-two aduld SD rats,were randomized in four groups(n=8):normal control group(group N),blank control group(group B),DAMGO group (group D)and DAMGO+CTOP group(group DC).A rat model was made by intraperitoneal injection of LPS at 6 hours after fracturing bilateral thighbone.Group N didn’t receive trauma and LPS,only anesthesia.The rats in group D received 200 μg/kg of DAMGO,group DC received 600 μg/kg of CTOP and 200 μg/kg of DAMGO,group B obtained the same amount of saline.6 hours after treat-ment,the arterial blood was collected for blood gas analysis,the lungs was harvested to observe lung tissue pathology change and dry-weight/wet-weight ratio,and the levels of MDA,TNF-α,IL-6,SOD activities in lung tissue were determined.Results The results of pathological observation showed that there was obvious inflammatory reaction in lung tissues after two-hits.Compared with group D, PaO2 ,pH and dry-weight/wet-weight ratio were significantly lower in group B and group DC(P <0.05),The score of Smith were significantly increased(P <0.05).The levels of MDA,TNF-α,IL-6 in lung tissue were significantly reduced in group D than those in group B and group DC(P <0.05), SOD activities in group D were significantly higher than those in group B and group DC(P <0.05 ). Conclusion μ-Opioid receptor DAMGO agonist has protective effect on acute lung injury induced by trauma-LPS two hits in rat model.

Eosinophil disorders are a range of heterogeneous diseases, which manifest as persistent increase of eosinophile granulocyte in blood and tissue, and may cause microenvironment change and irreversible chronic organ damage. According to World Health Organization, eosinophil diseases were divided into hypereosinophilia (HE) and hypereosinophilia syndrome (HES) by whether the organ is involved. Besides familial HE, HE were also divided into secondary (reactive) HE, primary (clonal/neoplastic) HE, and idiopathic HE. Lymphocytic variant HE is a special kind of secondary HE. With the study of the molecular mechanism of lymphocytic variant HE, the diagnosis is gradually clear. Moreover, some targeted therapeutic drugs, such as anti IL-5 monoclonal antibody (Mepolizumab) and anti CD 52 monoclonal antibody (Alemtuzumab) were also appeared. In this paper, the current basic and clinical researches of lymphocytic variant HE are reviewed.

Fluoropyrimidines are still the basic agents for adjuvant chemotherapy of colon cancer,a regimen containing 5-FU/LV/oxaliplatin (FOLFOX or FLOX) is the new standard for adjuvant settings,and FU/LV alone (Mayo,Roswell Park or LV5FU2) or single agent of capecitabine should be a choice of treatment for some particular patients; irinotecan should not be used for the adjuvant setting of colon cancer,because currently there is no evidence to show additional survival benefi t with addition of irinotecan to the adjuvant treatment,but increased risk of chemotherapy-related toxicity. Stage Ⅲ colon cancer is the main and defi nite indication for adjuvant chemotherapy,while adjuvant chemotherapy should not be routinely considered for stage Ⅱ colon cancer,except those with high risk factors including T4 tumor,obstruction,perforation,poor differentiation,invasion to nerve or vessels,and less than 12 examined lymph nodes. The age should not exclude the adjuvant chemotherapy if there is an adequate performance status. Adjuvant chemotherapy should be started within 8 weeks after surgery,and the current optimal duration for adjuvant chemotherapy of colon cancer should be six months.

Abtract:Purpose To analyze epidemiological characteristics and pathological types of 1 645 renal biopsies in Jiangsu province. Methods The reports of 1 654 percutaneous renal biopsies performed from January 2009 to June 2013 were retrospectively analysed . Results 1 597 out of 1 645 renal patients were successfully biopsied with a success rate of 97. 1%. Primary glomerular diseases ac-counted for 78. 56% of the total patients, secondary glomerular diseases 18. 71%. IgA nephropathy and mesangial proliferative lession accounted for high percent of primary glomerular diseases. Lupus nephritis was the most frequent pathologic type of secondary glomeru-lar diseases, followed by allergic purpura nephritis and diabetic nephropathy. Mesangial proliferative glomerulonephritis and hyperten-sive renal injury were more common in the Southern than in the Northern Jiangsu province, while acute tubular necrosis and allergic purpura nephritis were less in the Southern Jiangsu province. Conclusions Primary glomerular disease is still the most frequent glo-merular diseases in Jiangsu province, among which the IgA nephropathy was predominated. In secondary glomerular disease, lupus ne-phritis is the most frequent pathological type. The incidences of kidney diseases have geographical variation.

Treatment options are limited for triple negative breast cancer (TNBC)since endocrinother-apy and targeted therapy that aims directly at human epidermal growth factor receptor-2 (HER-2)are ineffec-tive.As such,in addition to surgical treatment,the mainstay of treatment of TNBC is systemic cytotoxic chemo-therapy.The targeted therapy of TNBC is becoming a research hotspot because of traditional chemotherapy cura-tive effect is not good enough.A large number of clinical trials have found that patients with TNBC can get ben-efits from targeted molecular strategies including poly-adenosine diphosphate glucose pyrophospheralase-ribose polymerase-1 (PARP-1 )inhibitor and epidermal growth factor receptor (EGFR)inhibitor.

Objective 6 recurrent cases of Primary retroperitoneal tumors(PRPT) after opertion were reviewed, to discuss the value of dignosis of recurrent PRPT in ultrasonography. MethodsAll (4 men and 2 women) were verified by operation and biopsy. Results4 of 6 cases were sarcomas, 4 cases were recurred once time, two times and four times each one. ConclusionUltrasonography can not only diagnose location of PRPT, but also provide reliable information for therapy or surgery. It can also be used in finding out the local recurrent masses after operation. Follow-up must be important in sarcoma.