Diffuse large B-cell lymphoma (DLBCL) represents the most common type of malignant lymphoma. DLBCL is heterogeneous with respect to morphology, immunophenotype, biology, clinical presentation and outcome. Constitutive activity of the NF-κB pathway may contribute to the poor prognosis of patients with activated B cell-like (ABC) subgroup of DLBCL, caspase recruitment domain 11 (CARD11) is the important signal protein in the signaling pathway of NF-κB. Furthermore, various pre-clinical data have proved the importance of CARD11 in DLBCL. This review summarizes the biological characteristics of CARD11, and its relationship with NF-κB signaling transduction pathway and the outcome of DLBCL, so that we can better understanding the pathogenesis and new therapeutic target of DLBCL.

Objective To study the longitudinal change of Migraine patient′s condition ,quality of life and disability ;analyze the evolution of the relationship between headache frequency ,pain intensity ,medication and treatment efficacy .Methods Continuous registration of migraine patients ,using WHO-DAS Ⅱ to assess the disability ,using MSQ2 .1 to assess the health-related quality of life ,using headache diary to record the patient′s condition .Results Compared the conditions of before and after treatment ,the aver-age level of pain ,acute drug using and headache frequency ,were significantly improved .The three dimensions′scores of MSQ2 .1 were decreased .Conclusion In this study ,significant improvement were found in some of the disability and health-related quality of life .Continuity of treatment has an important role to improve health-related quality of life of patients and reduce disability .

Objective Detected Her-2/neu, matrix metalloproteinases-2 (MMP-2) and Leptin in stomach cancer serum and tissue, discussed their roles in occurance and development of gastric cancer. Methods Detected the ex-pression of Her-2/neu, MMP-2 and Leptin in serum by ELISA, and detected the expression of Her-2/neu, MMP-2 and Leptin in stomach cancer tissue by IHC. Results The positive rates of Her-2/neu, MMP-2, Leptin in gas-tric cancer serum were higher than the positive rates in control group ( P<0.05 ) . The positive rates of Her-2/neu, MMP-2, Leptin in gastric cancer tissues were higher than the positive rates in adjacent tissues (P<0.05 ). The positive expressions of two tests had consistency. In tissues, the positive expression rates of Her-2/neu,MMP-2 and Leptin were correlated with the depth of invasion,lymph node metastasis, clinical stage(P<0.05). Their ex-pression was not correlated with sex, age, size, site of tumor and the degree of differentiation. In serum, the posi-tive expression of Her-2/neu was correlated with the depth of invasion, lymph node metastasis, clinical stage( P<0.05 ) . The positive expression of MMP-2 was correlated with lymph node metastasis ( P<0.05 ) . The positive ex-pression of Leptin had no significant correlation with pathological features. Conclusion Her-2/neu,MMP-2 and Leptin promote the occurrence, development and transfer process of gastric cancer. It can be used for clinical diag-nosis, guide the targeted therapy and provide scientific and reasonable reference for gastric cancer prognosis.

BACKGROUND: Spiral CT three-dimensional reconstruction has been used to observe the femoral head coverage fate of developmental dislocation of the hip (DDH). However, most of research containing certain observing point, which lack of long-term follow-up and comprehensive analysis. This article wants to fill the gaps.OBJECTIVE: To study changes of femoral head coverage fate in DDH child after 3 years treatment by CT reconstruction. METHODS: Totally 73 patients with unilateral DDH treated by aluminium plate after manual close reduction was selected. Spiral CT scanning of femoral articulation was performed at 1 day before and 12, 24, and 36 months after reduction to measure the femoral head coverage fate changes. The normal hip of patient was served as control.RESULTS AND CONCLUSION: All patients were included in the 42-53 months follow-up. After treatment, the femoral head coverage fate of patients were obviously than that of before treatment (P<0.01), which gradually approach to the normal level in 3 years, the first year after treatment is a key period for acetabulum development.

Diagnostic Errors ; legislation & jurisprudence ; Humans

Biopsy, Fine-Needle ; Cytodiagnosis ; methods ; Cytological Techniques ; methods ; Humans ; Neoplasms ; diagnosis ; pathology ; Quality Control

Alzheimer Disease ; etiology ; prevention & control ; Cytokines ; physiology ; Humans ; Inflammation ; complications ; Interleukin-1 ; physiology ; Nerve Growth Factors ; Risk Factors ; S100 Calcium Binding Protein beta Subunit ; S100 Proteins ; physiology

Alzheimer Disease ; pathology ; China ; Genes, p53 ; Glial Fibrillary Acidic Protein ; metabolism ; Humans ; Multiple Sclerosis ; pathology ; Nervous System Neoplasms ; classification ; genetics ; metabolism ; pathology

Objective To understand the blood glucose level and snacking habits in both healthy pregnant women and those with abnormal glucose tolerance during their mid pregnancy,for the purpose of providing reference for implementing nutrition education and intervention programs.Methods A questionnaire interview on snack habits,physical activity,sleep quality was conducted among 166 pregnant women in Shanghai Sixth People's Hospital.Subjects were then divided into normal group (n=97) and abnormal group (n=69) according to the results of blood glucose screening.Results There were no differences in snack intake and the energy generated from the three major nutrients between the two groups of women.However comparing to the normal group,women in abnormal group were more likely to choose the glutinous rice (17.4％ vs.4.1％),cake (37.7％ vs.20.6％) and dried fruit (13.0％ vs.4.1％),while comparing with women in abnormal group,women in normal group tend to choose vegetables (28.9％ vs.11.6％) and nuts (64.5％ vs.47.8％) as between-meal snacks.Conclusion The study suggested that pregnant women may continue the principle of frequent meal at reduced volume everyday,while starting to learn how to make good selection of high-nutrient-density snakes.

OBJECTIVE:To optimize the processing technology for Atractylodes lancea stir-baking with bran. METHODS:Us-ing the content of atractylodin,yield of water-soluble extract and ethanol-soluble extract,appearance score as comprehensive in-dex,the effects of excipient amount,stir-baking time and temperature on the quality of A. lancea stir-baking with bran were investi-gated by Box-behnken design-response surface method,so as to optimize the processing technology parameters of A. lancea stir-bak-ing with bran,and verification test were conducted. RESULTS:The optimized parameters were that the excipients amount was 10% medicinal material,stir-baking at 140 ℃ for 3 min;average comprehensive score of verification test was 0.39 (RSD=2.88%,n=3),which was close to predicted value 0.38. CONCLUSIONS:Box-behnken response surface method is reasonable and feasible for the optimization of the processing technology for A. lancea stir-baking with bran.