Autophagy ; Humans ; Myocytes, Cardiac ; Ventricular Remodeling

OBJECTIVETo explore the regulation and clinical significance of intestinal dripping of Jianpi Tongli (JPTL) Chinese herbs on levels of serum cytokines, such as interleukin-2 (IL-2), soluble interleukin-2 receptor (sIL-2R) and interleukin-12 (IL-12) in treating patients with gastric cancer (GC) at early post-operational stage.

METHODSSixty patients with GC were randomly divided into two groups, i. e. the studied group (n = 30), treated with JPTL Chinese herbs, and the control group (n = 30) treated with normal saline. The medication was started from the 1st day after operation by intestinal dripping daily, 7 days as one course. Levels of IL-2, sIL-2R and IL-12 were observed before and after operation.

RESULTSSignificant difference was seen on the 7th day post-operation between the studied and the control group, mainly in aspects of obvious increase of IL-2 and decrease of sIL-2R (P <0.05), no significant difference in IL-12 was found (P >0.05) though there was certain improvement. Compared with pre-operation of the same group, significant difference was found in the studied group in the increased IL-2 and IL-12 and decreased sIL-2R on the 7th day post-operation, while no significant difference in these indexes was found in the control group (P >0.05), though certain improvement was shown.

CONCLUSIONEarly intestinal dripping of JPTL Chinese herbs to post-operational patients with GC could improve their immune function, which was of important significance in early preventing the severe complications, improving the prognosis, and elevating the survival rate.

Adenocarcinoma ; blood ; drug therapy ; surgery ; Adult ; Aged ; Combined Modality Therapy ; Drugs, Chinese Herbal ; administration & dosage ; Female ; Humans ; Interleukin-12 ; blood ; Interleukin-2 ; blood ; Intestine, Small ; Intubation, Gastrointestinal ; Male ; Middle Aged ; Phytotherapy ; Postoperative Period ; Receptors, Interleukin-2 ; blood ; Stomach Neoplasms ; blood ; drug therapy ; surgery

Objective To analyze the epidemiological characteristics of mumps in 2012 and 2014,and to explore the preventive effect of the second dose of mumps-containing vaccine (MuCV) in mumps in Shandong province.Methods On the basis of certain model assumptions,a Space State model was formulated.Iterated Filter was applied to the epidemic model to estimate the parameters.Results The basic reproduction number (R0) for children in schools was 4.49 (95％ CI:4.30-4.67)and 2.50 (95％CI:2.38-2.61) respectively for the year of 2012 and 2014.Conclusions Space State model seems suitable for mumps prevalence description.The policy of 2-dose MuCV can effectively reduce the number of total patients.Children in schools are the key to reduce the mumps.