1.Clinical Implication of HBV Serum Markers Detected with Chemiluminescent Immunoassay in Inpatients of Xi'an Area
Juan XIE ; Wenkang LIU ; Ling LI ; Jie CHI ; Rong LIU ; Chao DONG ; Futang YAN
Journal of Modern Laboratory Medicine 2017;32(3):40-44
Objective To obtain serological prevalence data for HBV markers in inpatients of Xi'an area with consequence of providing basis for nosocomial infection control and clinical stuff.Methods The serological markers of HBV (HBsAg,HBsAb,HBeAg,HBeAb,HBcAb) in serum of inpatients including 5 248 males and 5 345 females in 2015 were quantitatively detected by chemiluminescent analyzer ARCHITECT i4000SR.Results The infection rate of HBV was 7.01% (743/10593) and there were 14 patterns of HBV serum markers in inpatients.Of all patterns of HBV infection in this study,there were 5.17 % (548/10 593) with HBsAg+ HBeAb+ HBcAb+,1.34 % (142/10 593) with HBsAg+ HBeAg+ HBcAb+,0.25% (27/10 593) with HBsAg+HBcAb+ and 0.25% (26/10 593) with other uncommon ones.Of all patterns of HBV convalescent stage,there were 21.02% (2 227/10 593) with HBsAb+,13.71% (1 452/10 593) with HBsAb+HBeAb+ HBcAb+,and 15.07% (1 596/10 593) with HBsAb+HBcAb+.The percentage of five serum markers with negative was 31.38% (3 324/10 593).There existed statistical difference for patterns of HBV serum markers concerning gender and different age groups,respectively (P<0.05).The clinical departments with highest percentages of HBsAg-+-HBeAg+ HBcAb +-,HBsAg+ HBeAb+ HBcAb+ and HBsAb+ were department of gastroenterology with 7.39 % (36/487),department of gastroenterology with 16.43% (80/487) and thoracic surgery one with 89.23% (58/65),respectively.Conclusion This study provided clinical data of management and controlling the transmitting of HBV and promotion of HBV vaccination.Meanwhile it is necessary for government to take effective measures to reduce the infection rate of HBV in Xi'an area.
2.Rescue stenting after failure of mechanical thrombectomy in patients with large vessel occlusive stroke
Chunxia ZHAO ; Futang XIE ; Wanchao SHI ; Chen LI
International Journal of Cerebrovascular Diseases 2018;26(10):731-736
Objective To investigate the safety and effectiveness of rescue stenting after failure of mechanical thrombectomy in patients with acute ischemic stroke (AIS) caused by large vessel occlusion (LVO). Methods From December 2015 to December 2017, patients with AIS caused by LVO and treated with Solitaire AB stent thrombectomy in the Fifth Central Hospital of Tianjin were enrolled retrospectively. CT scans were performed within 24 h after surgery. Symptomatic intracraninal hemorrhage (sICH) was defined as CT confirmed intracranial hemorrhage and the National Institutes of Health Stroke Scale score increased ≥4. Clinical outcomes were assessed using the modified Rankin Scale at 90 d after onset, and 0 to 2 was defined as good outcome. According to whether to receive rescue stenting or not, the patients were divided into 2 groups. The clinical outcomes and incidence of sICH were compared between the 2 groups. Results A total of 39 patients were enrolled. Among them, 29 (74. 3%) were successfully recanalized by mechanical thrombectomy and 10 (25. 6%) performed stenting after failure of mechanical thrombectomy. Four (40. 0%) in the stenting group and 11 (37. 9%) the non-stenting group had good outcomes respectively at 90 d. There was no significant difference (P = 1. 000). Two patients (20. 0%) and 1 patient (3. 4%) developed sICH within 24 h after operation in the stenting group and the non-stenting group respectively. There was also no significant difference (P = 0. 156). Conclusions Rescue stenting can be used as a safe and effective remedy for patients with failure of mechanical thrombectomy.
3.Mechanical thrombectomy with Solitaire AB stent for acute ischemic stroke: comparison between cardioembolic and large artery atherosclerotic stroke
Chunxia ZHAO ; Wanchao SHI ; Futang XIE ; Chen LI
International Journal of Cerebrovascular Diseases 2018;26(6):401-406
Objective To compare the outcomes of Solitaire AB stent mechanical thrombectomy for the treatment of large-artery atherosclerotic stroke (LAA) and cardioembolic stroke (CES).Methods Acute ischemic stroke patients treated with Solitaire stent retriever device were enrolled retrospectively. They were divided into either a LAA group or a CES group according to the etiology. The outcomes in both groups were compared. Multivariate logistic regression analysis was used to determine the independent risk factors for poor outcome (defined as the modified Rankin Scale score > 2) at 90 d after onset. Results A total of 39 patients were enrolled in the study. There were 18 patients in the LAA group (49. 2%), 6 (33. 3%) had good outcome at 90 days; there were 21 patients (50. 8%) in the CES group, 9 (42. 9%) had good outcome at 90 days. There was no significant difference in the the good outcome rate at 90 days in both groups (P = 0. 223). Multivariate logistic regression analysis showed that only age was independently associated with poor outcome (odds ratio 1. 107, 95% confidence interval 1. 016-1. 206; P = 0. 047), and stroke etiology subtype was not independently associated with poor outcome (odds ratio 0. 671, 95% confidence interval 0. 078- 5. 743; P = 0. 716). Conclusions There was no significant difference in the clinical outcome between the patents with LAA and CES who received mechanical thrombectomy with Solitaire AB stent.