Matrix metalloproteinase (MMP)-9 is closely correlated with the pathophysiological processes of cerebral edema,inflammatory reaction and apoptosis after intracerebral hemorrhage.As a specific brain-derived protein,the different levels of S100B may present different physiological and pathological effects.Its concentration can reflect the degree of central nervous system damage.This article reviews the action mechanisms of MMP-9 and S100B in intracerebrai hemorrhage.

In-stent restenosis after interventional treatment remains an unsolved and important clinical problem. The proliferation and migration of arterial smooth muscle cells are key events frequently followed by vascular restenosis after angioplasty and continuous inflammation may also be the other important factor for the restenosis after stenting. Study of the pathogenesis of restenosis may find some potentially novel therapeutic pathways for attenuating in-stent restenosis.

Objective To determine the influence of Fe2O3 coloring method to the mechanical and transparency parameter of dental zirconia.Methods Presintered zirconia blocks were coverd with zirconia powder blended with different ratio of Fe2O3,then sintered to 1450℃.Mechanical property and transparency parameter were calculated.Results The L* value was in the range from 64.91 to 90.94.The a* value was in the range from 1.27 to 12.70.The b* value was in the range from 1.02 to 38.66.There was no significant difference (P ＞ 0.05) of the flexural strength and in each group with the increase of Fe2O3.Conclusion This method produced dental zirconia specimens with light yellow to amber brown colors with the increase of Fe2O3 and no significant influence of mechanical property and transparency.

This paper discusses the brachytherapy with tumour interventional radiology technology.The structure and security of the intravascular iridium-192 sources afterloader are reviewed in comparison with general afterloader.

Objective:To study the relationship between graduate students'personalities, life events and psychic symptom.Methods:828 graduate students in Tianjin were investigated, their psychosomatic symptoms were rated with SCL-90 and psychosocial factors were assessed with Cattell 16 Personality Factors Questionnaire and Life Event Scale.Result:The first three factors in the psychosomatic symptoms were displayed in order: Obsession-compulsion(0.67?0.55), Interpersonal sensitivity (0.61?0.56), and Depression(0.50?0.51).The personalities were revealed as follows: E (6.23?1.69) , F(6.23?1.80) and Q 4(6.12?1.10), these factors were higher than Chinese norm, L (3.82?1.62), O (4.64?1.70) and I (4.86?1.62) were lower than norm.Conclusion:Male, having siblings, engineer and negative scores of work and study are risk factors for psychosomatic symptoms, whereas medical staff is a protective one.

Objective · To explore the clinical application value of hysteroscopic transcervical resection of endometrium (TCRE) combined with levonorgestrel-releasing intrauterine system (Mirena) in the treatment of adenomyosis. Methods · A total of 112 cases of adenomyosis patients were divided randomly into the combination group and Mirena group. The combination group (56 cases) was treated by TCRE endometrium endometrial resection, assisted Mirena treatment after operation. Mirena group (56 cases) was treated by Mirena only. The follow-up lasted 36 months after treatment, including measures of the volumes of menstrual bleeding, hemoglobin levels, dysmenorrhea scores, uterine volume, serum CA125 levels and incidences of complications.Results · The median follow-up duration was 42 months, and the three-year follow-up rate was 73.21% for the combination group and 50% for the Mirena group. After surgery, the volumes of menstrual bleeding of patients in 3-36 months decreased significantly, with an increase in hemoglobin level and a decrease in serum CA215 level and dysmenorrhea scores. Compared with their situations before surgery, the difference was significant (P<0.05). A comparison of uterine volume before and after surgery showed that there is a significant decrease in the uterine volume in both groups in6-12 months after surgery (P<0.05).Twenty-four months after surgery, it shows thatthe combination group has a much more significant decrease in uterine volume [(171.3±34.8) mm3] than Mirena group [(213.7±38.6) mm3] (P<0.05). The hysterectomy rate in Mirena group was significantly higher than that in the combination group (12.50% vs 5.36%); the ring expulsion rate was 16.07% in Mirena group and 5.36% in the combination group, and the break through bleeding happeningrate was 8.93% in Mirena group and 3.57% in the combination group. After 36 months an irregular small amount of vaginal bleeding rate was 62.25% in Mirena group, while it was only 12.50% in the combination group. There was significant differencewhen comparing above indices between two groups (P<0.05). There was no obvious differences in most common side effects of both groups. Conclusion · HysteroscopicTCRE combined with Mirena reduces significantly the irregular menstrual bleeding caused by merely applying Mirena. It has a prominent clinical efficacy and can be an effective approach in treatment of adenomyosis.

Objective To study the effect of eicetaxin combined with psychological intervention on early cognitive function in the patients with hip arthroplasty.Methods From January 2015 to December 2016 in our hospital, 80 cases with hip arthroplasty were selected as the research object, which were divided into two groups (the control group and the observation group) according to intervention methods, 40 cases in each groups.The control group were given dicetaxin, the observation group were received dicetaxin combined with psychological intervention.The clinical data in the two groups were compared.Results After intervention, the cognitive function in the observation group was better than that in the control group;the clinical intervention effect in the observation group (95.0%) was better than that in the control group (72.5%);The incidence of adverse reactions (7.5%) in the observation group is lower than that in the control group (40.0%).The difference of the above data in the two groups was statistically significant(P< 0.05).Conclusion The clinical effect is significant that dezocine combined with psychological intervention were used on patients with hip arthroplasty, which can improve the early cognitive function in the patients, is worthy of clinical application.

OBJECTIVE: To study the feasibility and the generalizability of the Remote fitting models of hearing AIDS from primary hospitals. METHOD: we comparative analyzed the speech recognition scores and satisfaction of 45 cases with traditional hearing AID fitting and with a hearing aid remote test respectively. RESULT: 45 cases were analyzed in each group, including traditional hearing AID fitting model and remote test, and 35 recovered in traditional fitting model group, and the recovery rate was 77.8%; Remote fitting model rehabilitation 42 cases, recovery rate was 93.3%, the difference was statistically significant (P < 0.05). In 6 weekend wear hearing AIDS, traditional fitting model of speech recognition rate increased by 19.40% on average, the average distance fitting model speech recognition rate increases by 27.47%, the average distance fitting model than traditional fitting the speech recognition rate increased significantly more (8.07%). Effect of hearing aid international questionnaire results suggest: 45 cases using traditional model fitting hearing AIDS patients, 33 cases (73.3%) satisfaction, 12 cases (26.7%) patients after use. Remote and 45 cases of using hearing AIDS fitting model, satisfied with 40 cases (88.9%), 5 cases (11.1%) patients after use. CONCLUSION the curative effect and the satisfaction of remote fitting models of hearing AIDS on hearing impairment are better than that in patients with traditional fitting models. Therefore it is more worthy of clinical application especially in basic level hospitals.
Audiometry ; Hearing Aids ; Hearing Loss ; rehabilitation ; Hearing Tests ; Humans ; Patient Satisfaction ; Remote Consultation ; Speech Perception ; Surveys and Questionnaires

Objective To investigate the levels and clinical significance of monocyte chemoattractant protein (MCP)-1 and tissue factor (TF) in patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD).Methods Forty-nine elderly patients with AECOPD(AECOPD group) and 30 healthy controls (control group) were selected,and AECOPD group was divided into procalcitonin (PCT) increased group (PCT ≥ 0.5 μ g/L,19 cases) and PCT normal group (PCT ＜ 0.5 μ g/L,30 cases) according to the level of serum PCT.The levels of plasma TF,serum MCP-1 and PCT were determined by enzyme linked immunosorbent assay.Results The levels of plasma TF and serum MCP-1 were (203.6 ± 92.9),(152.8 ±99.9) ng/L in AECOPD group,and (136.9 ±24.3),(87.5 ±41.5) ng/L in control group.There were significant differences in the levels of plasma TF and serum MCP-1 between AECOPD group and control group (P＜0.01).The level of plasma TF was positively correlated with serum MCP-1 (r =0.673,P=0.029).The levels of plasma TF and serum MCP-1 were (215.3 ±71.2),(181.1 ±61.6) ng/L in PCT increased group,and (192.4 ±79.7),(137.3 ±74.4) ng/L in PCT normal group.There were significant differences in the levels of plasma TF and serum MCP-1 between PCT increased group and PCT normal group (P＜0.05).Conclusions In patients with AECOPD,hypercoagulability state is activated,and it is more severe in the patients with increased PCT.The level of plasma TF is positively correlated with serum MCP-1 in patients with AECOPD.To monitor the levels of plasma TF and serum MCP-1 is particularly important for elderly patients of AECOPD with hypercoagulability state to prevent cardiovascular,lungs and cerebrovascular thrombotic disease.

[Objective] To establish a determination method for isolated gastrointestinal intra-cavity perfusion pressure and to explore its application in pharmacological experiment. [Methods] Determination method for isolated gastrointestinal intra-cavity perfusion pressure was established according to motility of the isolated rat gastric muscle strip and water-sac perfusion manometry and ileum peristalsis of Guinea pigs. Intra-cavity pressure of isolated gastrointestinal canal of rat and guinea pig was observed. [Results] Gastric intra-cavity pressure was markedly increased as added with various doses of acetylcholine (1.25, 2.5, 3.25, 5, 6.25 and 7.5 ?g/mL respectively) in nutrient solution. The ileum intra-cavity pressure was also increased as added with various doses of histamine (0.125, 0.25, and 0.5 ?g/mL respectively) . The effects were in a dose-effect manner and the differences were significant as compared with distilled water group ( P