1.The clinical observation of fluticasone salmeterol inhaler combined with salbutamol inhalation of oxygen-driven treatment of chronic obstructive pulmonary disease with acute exacerbation
Chinese Journal of Primary Medicine and Pharmacy 2012;19(4):483-484
Objective To observe the clinical efficacy of fluticasone salmeterol inhaler combined with salbutsmol inhalation of oxygen-driven treatment of chronic obstructive pulmonary disease with acute exacerbation.Methods 60 patients of chronic obstructive pulmonary disease with acute exacerbation,randomly divided into observation and control groups of 30 patients each.The control group on the basis of conventional treatment with salmeterol plus fluticasone inhalation powder compound and the oxygen-driven albuterol inhalation aerosol liquid,the other group by conventional therapy based on the use of oxygen-driven albuterol inhalation aerosol solution,then compare the clinical curative effects.Results There were 18 examples excellencely,10 examples improve,2 examples ineffective of observation group with total effective rate 93.3% ; 9 examples excellencely,11 examples improve,10 examples ineffective of control group with total effective rate 66.7%.The contrast of total effective power with the two groups exists the statistical significance ( x2 =4.60,P < 0.05 ) . In the observation group,FEV1 and FVC of post-treatment,were better than pretherapy and post-treatment of control group(t =2.629,2.649,2.064,2.051,P <0.05).Conclusion Salmeterol and fluticasone propionate inhalation powder hybrid atomizing inhalation of salbutamol effective than salbutamol alone.
2.Measurement and clinical significance of IL-8 、IL-13 and IL-18 in serum of patients with bronchial asthma
Chinese Journal of Primary Medicine and Pharmacy 2012;19(7):983-984
ObjectiveTo investigate the change and significance of IL-8,IL-13 and IL-18 level in serum of patients with bronchial asthma.Methods45 patients with acute exacerbation of bronchial asthma were selected (acute group),and remission group 45 patients and 30 healthy persons (control group) were selected.The serum IL-8,IL-13 and IL-18 levels were measured respectively by ELISA.ResultsThe serum IL-8,IL-13 and IL-18 levels in acute group were significantly higher than that in control group and remission group ( t =5.21,5.13,4.99,5.32,5.48,5.59,P < 0.05 ) ; The serum IL-8,IL-13 and IL-18 levels in remission group were significantly higher than that in control group(t =4.18,4.71,4.89,P <0.05).ConclusionThe levels of serum IL-8,IL-13 and IL-18 may be related to the severity of asthma attack.IL-8,IL-13 and IL-18 played important role in both pathogenesis and determination of asthma.
3.Clinical observation on the treatment of breast cancer with traditional Chinese and western medicine
International Journal of Traditional Chinese Medicine 2012;34(7):610-612
Objective To explore the influence of breast cancer treated with chemo-therapy and Shengxue decoction.Methods 91 Cases of breast cancer were randomly recurited into two groups:The western medicine treatment group (40 patients) was given anastrozole tablets and chemo-therapy; The Chinese and western medicine treatment group (51 patients) was given chemo-therapy and Shengxue decoction.Results The total effective rate of was 82% and 53% in the Chinese and western medicine treatment group and western medicine treatment group respectively,the difference was statistically significant (x2=19.74,P<0.05).The peripheral blood's CEA and MMP-2 mRNA expression of western medicine treatment were [ (7.50 ±4.32)ng/ml、(116.32±67.40)ng/ml respectively],higher than the Chinese and western medicine treatment group [ (7.20 ± 3.22) ng/ml、(105.08 ± 37.82) ng/ml,respectively,P< 0.05 ],but the TIMP-2/MMP-2 (26.65 ±19.75) was significantly lower compared with the Chinese and western medicine treatment group [ (39.48±21.21) (P<0.05) ].Conclusion The combination of traditional Chinese and western medicine was effective in treatment of breast cancer and well worth for popularization.
4.Clinical evaluation research of medical device registration
China Medical Equipment 2015;(2):34-36,37
Objective: To help medical device registration applicant understand the content of clinical evaluation, guided on the clinical evaluation method, and also putted forward several suggestions of the improvement scheme for our country registered clinical assessment and review of the work. Methods:Described the Global Harmonization Task Force (GHTF) medical device registration guidance for clinical evaluation, combined with the status quo of supervision in China, and made some specific scheme on China's medical device of clinical evaluation work. Results: Introduced the contents of the clinical evaluation and the relationships between the factors, in order to help the medical device registration applicant and Chinese regulators to do clinical evaluation work of scientific and reasonable. Conclusion:The definition of medical device registration clinical evaluation should clear the clinical evaluation, and to develop guidance for clinical evaluation of the corresponding.
5.Toll-like receptor 2 and ischemic cerebral white matter lesion
International Journal of Cerebrovascular Diseases 2016;24(12):1125-1128
Toll-like receptor 2 (TLR2) is the most w idely expressed receptor in the Toll-like receptor family, and is also an important pattern recognition receptor of the innate immune system to pathogenic microorganisms. In addition, TLR2 can also identify endogenous risk signals and participate in non -pathogenic microbial inflammatory reaction in ischemic injury. The role of TLR2 and its signal transduction in ischemic cerebral w hite matter lesions have received more and more attention. This article reviews the relationship between TLR2 and ischemic cerebral white matter lesion.
6.Correlation between TCM Syndromes of Chronic Prostatitis and Texture of Prostate
Haisong LI ; Fuqiang HAN ; Yueqing LI
Journal of Traditional Chinese Medicine 1993;0(07):-
0.05,good in model fitting.Pearson test of other conditions in palpation:P
7.Psychosomatic Symptom,Personality Factor and Life Event of Graduate Students
Fuqiang MAO ; Zhentao LI ; Jianhua WANG
Chinese Mental Health Journal 2002;0(10):-
Objective:To study the relationship between graduate students'personalities, life events and psychic symptom.Methods:828 graduate students in Tianjin were investigated, their psychosomatic symptoms were rated with SCL-90 and psychosocial factors were assessed with Cattell 16 Personality Factors Questionnaire and Life Event Scale.Result:The first three factors in the psychosomatic symptoms were displayed in order: Obsession-compulsion(0.67?0.55), Interpersonal sensitivity (0.61?0.56), and Depression(0.50?0.51).The personalities were revealed as follows: E (6.23?1.69) , F(6.23?1.80) and Q 4(6.12?1.10), these factors were higher than Chinese norm, L (3.82?1.62), O (4.64?1.70) and I (4.86?1.62) were lower than norm.Conclusion:Male, having siblings, engineer and negative scores of work and study are risk factors for psychosomatic symptoms, whereas medical staff is a protective one.
8.Effect of dicetaxin combined with psychological intervention on early cognitive function in the patients with hip arthroplasty
Chunsheng LI ; Xiangwu KANG ; Fuqiang WANG
Chinese Journal of Biochemical Pharmaceutics 2017;37(7):294-295,298
Objective To study the effect of eicetaxin combined with psychological intervention on early cognitive function in the patients with hip arthroplasty.Methods From January 2015 to December 2016 in our hospital, 80 cases with hip arthroplasty were selected as the research object, which were divided into two groups (the control group and the observation group) according to intervention methods, 40 cases in each groups.The control group were given dicetaxin, the observation group were received dicetaxin combined with psychological intervention.The clinical data in the two groups were compared.Results After intervention, the cognitive function in the observation group was better than that in the control group;the clinical intervention effect in the observation group (95.0%) was better than that in the control group (72.5%);The incidence of adverse reactions (7.5%) in the observation group is lower than that in the control group (40.0%).The difference of the above data in the two groups was statistically significant(P< 0.05).Conclusion The clinical effect is significant that dezocine combined with psychological intervention were used on patients with hip arthroplasty, which can improve the early cognitive function in the patients, is worthy of clinical application.
9.Study on the relationship between complement activation and inflammatory reaction in tissues of the perihematoma in patients with intracerebral hemorrhage
Fuqiang GUO ; Xiaojia LI ; Longyi CHEN
Journal of Clinical Neurology 1992;0(01):-
72 h goups, respectively. A few tissues distant from the hematoma on the way into the cranium were taken from the 2 former groups as control. Immunohistochemistry staining and reverse transcription polymerase chain reaction (RT-PCR) were used to detected expression of complement facters C3 ,complement inhibitor (Clusterin),the infiltration of the inflammatory cells, the proliferation of neuroglia cells and the expression of cytokins.Results The immunohistochemistry staining showed that the expression of complement facter C3 got to the peak at 12~72 h (P
10.Changes of IL-8 and ICAM-1 in early stage of cerebral white matter damage and their correlations with prognosis in premature infants
Yang DUAN ; Fuqiang SUN ; Yueqin LI
Journal of Clinical Pediatrics 2014;(9):821-824
Objective To explore the IL-8 and ICAM-1 in premature infants with cerebral white matter damage (CWMD) and their correlations with prognosis. Methods One hundred and two cases of CWMD were selected from March 2009 to June 2012 as experimental group and 42 cases of normal preterm children were selected as control group. Serum IL-8 and ICAM-1 levels were measured during 48-72 h after birth. Motor development index (psychomotor developmental index, PDI) and mental development index (mental development index, MDI) were evaluated by Bayley scale. The correlations of IL-8 and ICAM-1 levels with prognosis were analyzed. Results Serum IL-8 and ICAM-1 levels in the experimental group were signiifcantly higher than those in the control group (P<0.05). MDI and PDI scores in the experimental group were signiifcantly lower than those in the control group (P<0.05). There were negative correlations of serum IL-8 and ICAM-1 levels with MDI (r=-0.64, P<0.05;r=-0.66, P<0.05)+and PDI (r=-0.70, P<0.05;r=-0.71, P<0.05). Conclusions Serum IL-8 and ICAM-1 levels in infants with CWMD are signiifcantly increased, and are negatively correlated with MDI and PDI scores.