OBJECTIVETo determine the effects of a 12-week qigong and aerobic exercise program on the physical well-being of relatively healthy elderly Japanese women.

METHODSIn the first study, 72 elderly Japanese women who were relatively healthy and naive to qigong completed the 12-week qigong and aerobic exercise program. Physical function, body composition, and abdominal fat were evaluated. In the second study, we examined the effects of qigong alone on physical function. Twenty-nine participants in each of two groups (divided according to their residences) underwent a 12-week program: qigong and aerobic exercise (residents in Yura Town) or qigong exercise alone (residents in Mihama Town).

RESULTSIn the first study, physical function including lung capacity, trunk bending, normal walking for 30 m, and rising from a supine position significantly improved after the 12-week program. In addition, body fat diminished significantly during the program. In the second study, both exercise programs ("qigong and aerobic" and "qigong alone") similarly increased walking speed (normal and maximum walking) and rising speed.

CONCLUSIONSThe findings of this exploratory study demonstrated that a 12-week qigong and aerobic exercise program was associated with improvements in physical function and a reduction in body fat. The qigong exercise program alone positively influenced physical function. The qigong program appears to be an appealing means of improving the physical health of elderly persons.

Malignant melanoma rarely originates from the female nipple. Tumors that develop on the skin of the breast are often subject to a delayed diagnosis. Cytologic examination provides excellent diagnostic capabilities and is a safe procedure with a lower risk of local implantation, compared to needle or incisional biopsy. We herein report a patient who underwent surgical resection of a primary malignant melanoma of the nipple. An elastic soft nodule was observed on the left nipple, and no abnormal lesions were identified in the breast. Eventually, a malignant melanoma was diagnosed from the clinical and cytological evaluation findings. This bulky tumor was classified as a stage IIIC nodular melanoma, with a thickness of 12 mm. The patient received adjuvant chemotherapy and exhibits no evidence of recurrence 7 years after surgery.
Biopsy ; Breast ; Chemotherapy, Adjuvant ; Delayed Diagnosis ; Female ; Humans ; Melanoma* ; Needles ; Nipples* ; Recurrence ; Skin

Background: and Purpose Differences in measurement of the extent of acute ischemic stroke using the Alberta Stroke Program Early Computed Tomographic Score (ASPECTS) by non-contrast computed tomography (CT-ASPECTS stratum) and diffusion-weighted imaging (DWI-ASPECTS stratum) may impact the efficacy of endovascular therapy (EVT) in patients with a large ischemic core. Methods: The RESCUE-Japan LIMIT (Recovery by Endovascular Salvage for Cerebral Ultra-acute Embolism Japan–Large IscheMIc core Trial) was a multicenter, open-label, randomized clinical trial that evaluated the efficacy and safety of EVT in patients with ASPECTS of 3–5. CT-ASPECTS was prioritized when both CT-ASPECTS and DWI-ASPECTS were measured. The effects of EVT on the modified Rankin Scale (mRS) score at 90 days were assessed separately for each stratum. Results: Among 183 patients, 112 (EVT group, 53; No-EVT group, 59) were in the CT-ASPECTS stratum and 71 (EVT group, 40; No-EVT group, 31) in the DWI-ASPECTS stratum. The common odds ratio (OR) (95% confidence interval) of the EVT group for one scale shift of the mRS score toward 0 was 1.29 (0.65–2.54) compared to the No-EVT group in CT-ASPECTS stratum, and 6.15 (2.46–16.3) in DWI-ASPECTS stratum with significant interaction between treatment assignment and mode of imaging study (P=0.002). There were significant interactions in the improvement of the National Institutes of Health Stroke Scale score at 48 hours (CT-ASPECTS stratum: OR, 1.95; DWIASPECTS stratum: OR, 14.5; interaction P=0.035) and mortality at 90 days (CT-ASPECTS stratum: OR, 2.07; DWI-ASPECTS stratum: OR, 0.23; interaction P=0.008). Conclusion Patients with ASPECTS of 3–5 on MRI benefitted more from EVT than those with ASPECTS of 3–5 on CT.