1.Comparison of Therapeutic Effects Between Ear Point Seed Embedding Method and Acupuncture in the Treatment of Female Menopause Syndrome
Dongmei SUN ; Qiuhua SHAN ; Fudong WU ; Guoqi HUANG
Journal of Acupuncture and Tuina Science 2004;2(4):29-32
To observe and compare the therapeutic effects of treating female menopausal syndrome with auricular-point-pressing therapy and acupuncture, 86 patients were randomly divided into auricularpoint pressing group and acupuncture group, the comparative observation was conducted according to a modified Kupperman index. Statistical analysis showed that there's no significant difference between the therapeutic effects of the two groups. Auricular-point-pressing therapy and acupuncture were both effective in treating female menopausal syndrome, while auricular-point-pressing had the advantages of easy operation and acceptance.
2.Comparative Observation on Therapeutic Effects of Treating Menopausal Syndrome with Auricular Points Sticking-pressure and Acupuncture
Dongmei SUN ; Xinhua CHAN ; Fudong WU ; Chouping HAN
Journal of Acupuncture and Tuina Science 2006;4(3):180-182
Objective: To make a comparative observation on treating menopausal syndrome with auricular points sticking-pressure and acupuncture. Methods:The 86 cases were randomized into the group of auricular points sticking-pressure and acupuncture group, and then the comparative observation was made according to the modified Kupperman index. Results: The statistical analysis on the comparative observation showed there is no significant difference between the therapeutic effects of the two groups. Conclusion: Auricular points sticking-pressure and acupuncture are both effective for menopausal syndrome, and the auricular points sticking-pressure is worthy to spread with its easy operation.
3.A comparative study of venlafaxine vs. paroxetine in treatment of peripheral vertigo patients with anxiety and depression
Jing DAI ; Qing SUN ; Fudong DENG ; Xizheng SHAN
Chinese Archives of Otolaryngology-Head and Neck Surgery 2016;23(10):590-593
OBJECTIVE To study the efficacyof venlafaxine vs. paroxetine in treatment of peripheral vertigo patients with anxiety and depression. METHODS 180 peripheral vertigo patients with anxiety and depressionwere randomly divided into venlafaxine group(90cases) and paroxetine group(90cases), and were treated respectively for 6 weeks. The patients were assessed by Dizziness Handicap Inventory(DHI), Hamilton Depression Scale24(HAMD) and Hamilton Anxiety Scale(HAMA) before and after the treatment at the 2nd, 4th and 6th week respectively. The clinical efficacy of the two drugs was evaluated according to the reduction rate before and after the treatment. RESULTS Atthe 2ndweek, the scores of HAMA in venlafaxine group was lower than paroxetine groupstatistically(P<0.05). At the 4th week, both the HMAM and HAMD in venlafaxine group were lower than paroxetine groupstatistically(P<0.05). After 6 weeks, The total effective rate of anxiety and depression were 83.33% and 77.78% in venlafaxine group, while 76.67%and 74.45% in paroxetine group. But there was no statistical difference(P>0.05). The scores of DHI were decreased in both groups(P<0.05), and index p in venlafaxine group was lower than paroxetine group(P<0.05). CONCLUSION Both of them can reduce the physical symptoms and dysfunction, are effective on anxiety and depression, but venlafaxine is faster to take effect than paroxetine, and has a better patient compliance.
4.An Automated Dual-gradient Liquid Chromatography-MS/MS Method for Simultaneous Determination of Four Kinds of Plants Hormones in Different Parts of Soya Beans and Its Application to a Real Analysis
Pengyu JIA ; Mingfei ZENG ; Naijie FENG ; Dianfeng ZHENG ; Fudong SUN ; Rui SUN ; Chaoyang LI
Chinese Journal of Analytical Chemistry 2014;(12):1743-1749
There are some common analysis challenges in the hormone detection in agriculture science, including matrix interference, complicated sample preparation, poor reproducibility, trace analyte content. An automated on-line SPE and innovative fast polarity switch analysis method employing dual-gradient liquid chromatography ( DGLC ) coupled with tandem mass spectrometry ( DGLC-MS/MS ) was established and validated for the simultaneous determination of gibberellic acid ( GA3 ) , indole acetic acid ( IAA ) , zeatin ( ZT) and abscisic acid ( ABA) in the soybean plant ( leaf, grain and pod) . The method was applied in the actual sample detection successfully. In order to acquire higher sensitivity, recovery, stability and precision, some conditions including SPE column, analytical column, mobile phase, additive etc were optimized according to the selection and retain of hormone. Beans were cryogenically grinded by liquid nitrogen, extracted by 80% methanol, certrifugatel and dilluted with water, and then injected directly. Samples were transported and gradient eluted on the analytical column Acclaim PA2 by 0 . 1% formic acid in water and methanol, after retaining and separation on the SPE column Hypersep Retain AX. All analytes were detected in selection reaction monitoring ( SRM) mode in both positive and negative channels. The quantification was based on linear regression. The linear ranges of GA3, IAA and ZT were 0. 1-50 μg/L with the LOQ of 0. 0002 μg/g, and the linear of ABA was 0. 5-50 μg/L with the LOQ of 0. 0010μg/g. The recoveries of four kinds of plants hormones were 76 . 1%-93 . 5%, and RSDs were 0 . 82%-6 . 02% at low ( 0 . 8 μg/L ) , medium (4. 0μg/L) and high (40μg/L). The results noted that the content of ABA in seeds was apparently higher than others. This method could be used for the rapid and accurate detection of hormone in different parts of soya beans.
5.Analysis on published scientific papers from 2001 to 2010 by professionals of provincial Center for Disease Control and Prevention in China
Hua GU ; Fudong LI ; Yongdi CHEN ; Jianzhong SUN ; Feng LIN ; Peiwei XU ; Junjie ZHOU
Chinese Journal of Medical Science Research Management 2013;(1):65-68
Objectives Through analyzing the published scientific papers from 2001 to 2010 by the professionals of the 31 provincial Center for Disease Control and Prevention in China,offer reference for making plan about scientific research,disciplinary areas,personnel training.Methods Literature quantitative analysis and health statistics methods were used to analyze these papers.Results The professionals in 31 provincial CDC published a total of 22079 papers,Zhejiang 1669(7.56%),Guangxi 1579 (7.15 %),Jiangsu 1410 (6.39 %) are the top 3 provinces.The ratio of published papers in Zhonghua medical journal among all the papers are 1366(6.19%),the first three provinces Tianjinlll (13.67%).Beijing160 (13.57%).Shaanxi34 (10.59%).Average papers published by the eastern,central and western regions are 1131,452,444,eastern above western regions (P =0.0065.P =0.0028).Conclusion In recent ten years,the quantity and quality of papers published by the professionals of provincial CDC in China were improved.The unbalanced development exist among eastern,central and western regions,But the majority CDC's papers should be strengthened further.
6.Effect of anesthesia factor on lung injury in patients undergoing thoracoscopic radical lung cancer surgery: combination of thoracic paravertebral block with dexmedetomidine mixed with ropivacaine and general anesthesia
Wei ZHANG ; Mingyang SUN ; Bing LI ; Fudong TANG ; Jiaqiang ZHANG
Chinese Journal of Anesthesiology 2018;38(1):34-39
Objective To investigate the effect of anesthesia factor on lung injury in patients un?dergoing thoracoscopic radical lung cancer surgery and to evaluate efficacy of combination of thoracic para?vertebral block(TPVB)with dexmedetomidine mixed with ropivacaine and general anesthesia. Methods One hundred patients of both sexes, aged 18-64 yr, with body mass index of 18-25 kg∕m2, of American Society of Anesthesiologists physical statusⅡorⅢ, scheduled for elective thoracoscopic radical lung cancer surgery, were divided into 5 groups(n=20 each)using a random number table: general anesthesia group (group G), TPVB with ropivacaine combined with general anesthesia group(group R), intravenously in?fused dexmedetomidine combined with general anesthesia group(group Div), intravenously infused dexme?detomidine plus TPVB with ropivacaine combined with general anesthesia group(group Div+R), and TPVB with dexmedetomidine mixed with ropivacaine combined with general anesthesia group(group Dtp+R). In group R, TPVB was performed under ultrasound guidance, two?point method was selected accord?ing to the position of intercostal space at surgical incision, and 0.5% ropivacaine 10 ml was injected into each puncture site. Dexmedetomidine 0.5 μg∕kg was intravenously infused over 10 min in group Div. Dexmedetomidine was intravenously infused for TPVB in group Div+R. TPVB solution contained dexmedeto?midine 0.5 μg∕kg and ropivacaine in group Dtp+R. Anesthesia was then induced and maintained by IV in?fusion of propofol and remifentanil. The intraoperative consumption of propofol and remifentanil and develop?ment of adverse reactions such as hypoxemia, hypotension and bradycardia were recorded. Normal lung tis?sues around the tumor margin were obtained immediately after tumor resection for determination of the ex?pression of hypoxia?inducible factor 1 alpha(HIF?1α), BCL2∕adenovirus E1B 19kDa interacting protein 3 (BNIP3)and microtubule?associated protein 1 light chain 3Ⅱ(LC3Ⅱ)(by Western blot), contents of tumor necrosis factor?alpha(TNF?α)and interleukin?6(IL?6)in lung tissues(by enzyme?linked immu?nosorbent assay)and cell apoptosis(by TUNEL)and for examination of the pathological changes(with a light microscope)which were scored. Apoptosis index was calculated. Results The amount of propofol consumed was significantly lower in Div+R and Dtp+R groups than in the other three groups, and the a?mount of remifentanil consumed was significantly higher in G and Div groups than in the other three groups (P<0.05). The incidence of hypertension and tachycardia was significantly lower in R and Div groups than in group G(P<0.05). The incidence of hypotension was significantly lower in R, Div and Dtp+R groups than in group Div+R(P<0.05). The incidence of bradycardia was significantly higher in Div and Div+R groups than in group R(P<0.05). Compared with G and R groups, apoptosis index, contents of TNF?α and IL?6 and lung injury scores were significantly decreased, and the expression of HIF?1α, BNIP3 and LC3Ⅱ was up?regulated in Div, Div+R and Dtp+R groups(P<0.05). Compared with group Div, the TNF?α content and lung injury scores were significantly decreased, and the expression of HIF?1α and LC3Ⅱwas up?regulated in Div+R and Dtp+R groups, and the IL?6 content was significantly decreased in group Dtp+R(P<0.05). Conclusion Combination of TPVB with dexmedetomidine mixed with ropivacaine and general anesthesia produces better efficacy in reducing lung injury in patients undergoing thoracoscopic radi?cal lung cancer surgery.
7.Investigation and Analysis of Medication Safety among 24 Medical Institutions in Linyi City
Yanlong QIU ; Tao WANG ; Xuesong ZHANG ; Wenqiang SUN ; Yan CHEN ; Min ZHAO ; Zhengrong LI ; Fudong SUN
China Pharmacy 2019;30(5):581-586
OBJECTIVE: To investigate the current situation of medication safety in 24 public medical institutions(referred to as “hospital”) from Linyi city and the differences in medication safety between urban and rural areas. METHODS: ISMP self-assessment scale [including 10 key elements (Ⅰ-Ⅹ,such as “Ⅰ patient’s information” “Ⅱ drug information”), 20 key characteristics and 270 evaluation projects] developed by Institute of Safe Medication Practices was used to investigate 24 hospitals in Linyi city. The implementation rates of 10 key elements in urban and rural hospitals were analyzed statistically, and the top 10 evaluation projects were listed for the key elements with the lowest implementation rate. The key elements and top 10 evaluation projects with the largest difference in the implementation rate were compared between urban and rural hospitals. Radar maps were used for comparison and analysis intuitively. RESULTS: A total of 24 hospitals were surveyed, including 12 in urban and 12 in rural areas; there were significant differences in the implementation rate of 10 key factors among 24 hospitals; the elements with the highest implementation rate were “Ⅶ environmental factors, workflow and staffing pattern”(56.55%);the elements with the lowest implementation rate was “Ⅱ drug information” (26.77%). Among 33 evaluation projects of “Ⅱ drug information”, the implementation rate of No. 36 project (12.50%, related to opioids) was the lowest. Among the implementation rates of 10 key elements in 12 urban hospitals and 12 rural hospitals, the key elements with the greatest difference was “Ⅳ drug label, packaging and naming” (differing by 44.44%,59.72% vs. 15.28%); Among“Ⅸ patient education”evaluation project with the greatest gap, there was the greatest difference in No. 199 project (related to patients’ active participation in medication, 58.33% in urban, 4.17% in rural). CONCLUSIONS: The results of medication safety investigation in 24 hospitals from Linyi city show that all the item in each hospital needs to be improved expecially in the implementation of “Ⅱ drug information”. Rural hospitals should strengthen medication education for patients.
9. Qualitative pathological assessment of liver fibrosis regression after antiviral therapy in patients with chronic hepatitis B
Yameng SUN ; Jialing ZHOU ; Lin WANG ; Xiaoning WU ; Yongpeng CHEN ; Hongxin PIAO ; Lungen LU ; Wei JIANG ; Youqing XU ; Bo FENG ; Yuemin NAN ; Wen XIE ; Guofeng CHEN ; Huanwei ZHENG ; Hai LI ; Huiguo DING ; Hui LIU ; Fudong LYU ; Chen SHAO ; Tailing WANG ; Xiaojuan OU ; Binqiong WANG ; Shuyan CHEN ; Hong YOU ; Jidong JIA
Chinese Journal of Hepatology 2017;25(11):819-826
Objective:
To investigate the methods for qualitative pathological assessment of dynamic changes in liver fibrosis/cirrhosis after antiviral therapy in patients with chronic hepatitis B (CHB), since antiviral therapy can partially reverse liver fibrosis and cirrhosis caused by hepatitis B and semi-quantitative, rather than qualitative, pathological assessment is often used for the research on liver fibrosis regression.
Methods:
Previously untreated CHB patients with liver fibrosis and cirrhosis were enrolled, and liver biopsy was performed before treatment and at 78 weeks after the antiviral therapy based on entecavir. The follow-up assessment was performed once every half a year. Based on the proportion of different types of fibrous septum, we put forward the new qualitative criteria called P-I-R classification (predominantly progressive, predominantly regressive, and indeterminate) for evaluating dynamic changes in liver fibrosis. This classification or Ishak fibrosis stage was used to evaluate the change in liver fibrosis after treatment and Ishak liver inflammation score was used to evaluate the change in liver inflammation after treatment.
Results:
A total of 112 CHB patients who underwent liver biopsy before and after treatment were enrolled, and among these patients, 71 with an Ishak stage of ≥3 and qualified results of live biopsy were included in the final analysis. Based on the P-I-R classification, 58% (41/71) were classified as predominantly progressive, 29% (21/71) were classified as indeterminate, and 13% (9/71) were classified as predominantly regressive; there were no significant differences between the three groups in alanine aminotransferase, aspartate aminotransferase, albumin, HBeAg positive rate, HBV DNA, and liver stiffness (
10. Combined anluohuaxianwan and entecavir treatment significantly improve the improvement rate of liver fibrosis in patients with chronic hepatitis B virus infection
Liang MIAO ; Wanna YANG ; Xiaoqin DONG ; Zhanqing ZHANG ; Shibin XIE ; Dazhi ZHANG ; Xuqing ZHANG ; Jun CHENG ; Guo ZHANG ; Weifeng ZHAO ; Qing XIE ; Yingxia LIU ; Anlin MA ; Jun LI ; Jia SHANG ; Lang BAI ; Lihua CAO ; Zhiqiang ZOU ; Jiabin LI ; Fudong LYU ; Hui LIU ; Zhijin WANG ; Mingxiang ZHANG ; Liming CHEN ; Weifeng LIANG ; Hui GAO ; Hui ZHUANG ; Hong ZHAO ; Guiqiang WANG
Chinese Journal of Hepatology 2019;27(7):521-526
Objective:
To explore the improvement rate of liver fibrosis in patients with chronic hepatitis B virus infection who received entecavir alone or in combination with anluohuaxianwan for 78 weeks.
Methods:
Patients with chronic HBV infection were randomly treated with entecavir alone or in combination with anluohuaxian for 78 weeks. Ishak fibrosis score was used for blind interpretation of liver biopsy specimens. The improvement in liver fibrosis condition before and after the treatment was compared. Student's t test and non-parametric test (Mann-Whitney U-Test and Kruskal-Wallis test) were used to analyze the measurement data. The categorical variables were analyzed by Chi-square test method and Spearman’s rank correlation coefficient was used to test bivariate associations.
Results:
Liver fibrosis improvement rate after 78 weeks of treatment was 36.53% (80/219) and the progression rate was 23.29% (51/219). The improvement of liver fibrosis was associated to the degree of baseline fibrosis and treatment methods (