Objective To investigate the influence of facial acne on the quality of life in college students.Methods The Quality of Life-Acne ( QOL-Acne) designed by Martin AR, the questionnaire of self-assessment on patients ’ severity and self-designed epidemiological questionnaire were used to investigate and analyze the quality of life in college students in order to explore the risk factors that affecting college students’ quality of life.Results The results of single factor Logistic regression analysis suggested that the risk factors affecting quality of life were gender, course of disease, clinical severity, self-assessment severity.The results of multi-factor Logistic regression analysis suggested that gender (β=-0.667,OR=0.475) and self-assessment severity (β=-0.713, OR=0.534) were significantly associated with the quality of life in college students. Conclusions The facial acne can make greater influence on female students than male college students.The gender of college students and self-assessment severity are the risk factors affecting their quality of life.It is necessary for medical staff to carry out the related health education on facial acne in hospitals and at schools.