Objective: To investigate the possible mechanism of neuroprotection produced by taurine supplement on brain in young rats. Methods: In vitro, taurine treatment or co-treatment with sodium selenite that produced significant neuronal apoptosis was used in cultured cortical neurons to examine the neuroprotection effect using MTT assay and DNA fragmentation electrophoresis. In vivo, female weanling Sprague Dawley rats were divided into four groups, eight rats per group. The treated groups were fed on diets with different contents of taurine respectively, and the control group was fed on taurine unsupplemented diets. The experiment lasted five weeks. Results: Taurine significantly increased neuronal survival in dose-dependent manner. The typical DNA ladder pattern could be prevented by taurine. Taurine could elevate brain wet weight, and significantly increased the level of taurine, protein and AChE in brain. Conclusion: It is proposed that the neuroprotection effect of taurine could be achieved by modulating expression of related genes and blocking neuronal apoptosis.

Objective To explore the dietary intake and lifestyle risk factors that could cause gastric diseases in pa-tients, and to provide scientific basis for intervention. Methods Combined self-administered with face-to-face inter-view, the survey was performed using a self-made questionnaire. Results There were no statistically significant differ-ences in gender,BMI,satiety (P>0.05),while there were statistically significant differences in age, education level,the speed of eating, tastes, gluttony, watching TV during dinner, eating leftovers, chilled or frozen food, smoking,drinking,water source,vegetable intake,fruit intake between the two groups(P<0.01). Conclusion Age and education level were risk factors for the presence of gastric diseases; the dietary intake and lifestyle risk factors were particularly strong risk factors.

Objective:To systematically evaluate the relationship between gestational vitamin D deficiency and spontaneous abortion.Methods:Databases including PubMed, Web of Science, Ebsco, Cochrane, Embase, CNKI, Wanfang database, China Biomedical Literature Service System, etc. were searched for cohort studies and case-control studies on the correlation between gestational vitamin D deficiency/insufficiency and abortion outcomes, respectively from the establishment of individual database to December 2021. Two investigators independently performed literature screening, data extraction and risk of bias assessment for included studies. Meta-analysis was conducted with RevMan 5.4.1 and Stata 15.1.Results:Eventually, 12 cohort studies and 5 case-control studies were included. A total of 19,308 pregnant women were enrolled, among whom 1 405 abortions were observed. 8 studies were published in Chinese and 9 in English. 10 studies were from China and 1 study each was from Iran, Egypt, Sweden, United States, Denmark, Turkey and Australia. The standards for vitamin D deficiency and the diagnostic criteria for miscarriage were basically the same across studies. After adjusting for confounding factors such as age and race, the meta-analysis showed that gestational vitamin D deficiency/insufficiency would increase the risk of miscarriage. A subgroup analysis of women with miscarriage in early pregnancy showed results consistent with that in overall population. No significant publication bias were identified via meta-analysis.Conclusion:Gestational vitamin D deficiency and insufficiency are related to the occurrence of spontaneous abortion and can increase the risk of early spontaneous abortion.