Objective To study the effectiveness of phase Ⅰleft colon resection and anastomosis on serum insulin-like growth factor-1(IGF-1) and vascular endothelial growth factor (VEGF) in patients with acute intestinal obstruction.Methods 92 patients with acute intestinal obstruction were randomly divided into two groups ,the obser-vation group(n=46) and the control group(n=46).The patients in the observation group were operated through phase Ⅰleft colon resection and anastomosis ,while the patients in the control group were operated through Hartman . Serum IGF-1 and VEGF were measured in preoperative and postoperative patients .Results The observation group for the length of time (14.9 ±6.4)d,shorter than the control group(28.3 ±9.6)d(t=5.426,P<0.05);observation group,incision infection,anastomotic leakage were 2 cases,1 cases,the control group was 3 cases,1 cases,no signifi-cant difference between two groups (χ2 =2.19,1.29,all P>0.05);two groups of postoperative serum levels of IGF-1 and VEGF were significantly decreased ,compared with the control group ,the observation group was significantly lower (t=3.064,2.394,all P<0.05).Conclusion Phase Ⅰ left colon resection and anastomosis can significantly de-crease serum IGF-1 and VEGF levels in patients with acute intestinal obstruction .

Objective To explore the neuroprotective mechanism of propofol by comparing the influence of propofol and isoflurane on inflammatory cytokines ( TNF-α、IL-1、ICAM-1 ) in patients with intracranial tumors. Methods One hundred and sixty-eight patients with intracranial neoplasm were randomly divided into two groups:the propofol ( Group P) and isoflurane (Group I),84 cases in each. Patients were given with propofol (3-6 μg·mL-1) by plasma target-controlled infusion or with continuously inhaled isoflurane ( 1%-2%) , respectively. The serum levels of TNF-α, IL-1 and ICAM-1 were detected before anesthesia and at 0,24,and 48 h after operation. Results The serum levels of TNF-α,IL-1 and ICAM-1 were significantly increased after operation as compared to baseline in both groups. The serum level of TNF-α was(69. 11±8. 95) and (76. 26±11.28) μg·mL-1,IL-1 was(21.57±3.19) and (29.58±4.38) ng·L-1,and ICAM-1 was (1.63±0.24)and (1.94±0.29) g·L-1 at 24 h post operation in Group P and Group I,respectively. These inflammatory cytokine levels were significantly higher in group I compared to group P at 24 and 48 h after operation (P<0. 05 or P<0. 01). Conclusion The target-controlled infusion of propofol brings about lower level of inflammatory reaction than isoflurane inhalation in patients with intracranial neoplasm,which may attribute to the mechanism of brain protection against injury.

Objective To investigate the effect of acupuncture on gap junction protein Cx43 expression in the hippocampal region in ischemia/reperfusion rats.Methods Wistar rats were randomized into normal, model, non-point acupuncture and acupuncture groups. A rat model of focal cerebral ischemia/reperfusion was made by modified middle cerebral artery thread occlusion. The model, non-point acupuncture and acupuncture groups were separately divide into four subgroups: 30, 60, 180 and 360 min ischemia/reperfusion, 10 rats each. The middle and lateral lines of vertex were given electroacupuncture in the acupuncture group of rats. A subcostal fixed point 10 mm above the iliac crest on the affect side was selected as an acupuncture point in the non-point acupuncture group. The model group was not treated. Cx43 protein expression was determined by an immunohistochemical method.Results There was a statistically significant difference in the behavior disorder (Bederson’s) score between the acupuncture group and the non-point acupuncture or model group after different times of cerebral ischemia/ reperfusion (P<0.05). There was a statistically significant difference in hippocampal Cx43 content between model, acupuncture or non-point acupuncture group and the normal group and between the acupuncture group and the model or non-point acupuncture group after different times of cerebral ischemia/reperfusion (P<0.05).Conclusions Acupuncture can inhibit the overexpression of Cx43, intervene in cerebral ischemia-reperfusion injury and produce a neuroprotective effect in ischemic brain injury.