1.Drug induced radiation recall dermatitis
China Oncology 2006;0(12):-
Multiple modality treatment has been adapted for the treatment of various cancers,the outcome has been dramatically improved,but some of unique side effects due to the modalities like chemotherapy combined with radiotherapy have been observed in the clinic. Radiation recall dermatitis(RRD) is one of the side effects. In this paper,the etiology,clinical features,diagnosis,treatment and related factors of the radiation recall dermatitis are discussed.
2.From microdosimetry to nanodosimetry--the link between radiobiology and radiation physics.
Journal of Biomedical Engineering 2014;31(3):703-707
The link between micro- and macro-parameters for radiation interactions that take place in living biological systems is described in this paper. Meanwhile recent progress and development in microdosimetry and nanodosimetry are introduced, including the methods to measure and calculate these micro- or nano-parameters. The relationship between radiobiology and physical quantities in microdosimetry and nanodosimetry was presented. Both the current problems on their applications in radiation protection and radiotherapy and the future development direction are proposed.
Humans
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Physics
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Radiation Protection
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Radiobiology
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Radiometry
3.Interventional effect of acupuncture treatment at Yifeng, Ermen and Zhongzhu acupoints on auditory brain-stem response in gentamicin-induced hearing impairment
Ping FU ; Zhigang LI ; Enguang GENG
Chinese Journal of Tissue Engineering Research 2006;10(31):159-161
BACKGROUND: Some researches indicated that the acupuncture treatment, especially at Sanjiao meridian might be effective for otopathy. However, the mechanism is not clear yet.OBJECTIVE: To observe the hearing improvement of the cavies induced by gentamicin after the animals received the acupuncture at Sanjiao meridian acupoints: Yifeng (SJ 17), Ermen (SJ 21) and Zhongzhu (SJ 3).DESIGN: Complete randomization.SETTING: Department of Neurology, Xuanwu Hospital, Capital University of Medical Sciences.MATERIALS: Sixty healthy white male cavies of 3-4 months old, common grade, 250-300 g weight and normal auricle reflex were selected and randomly arranged into 5 groups: normal group, model group, acupuncture groups of Yifeng (SJ 17), Ermen (SJ 21) and Zhongzhu (SJ 3), with 12 ones in each.METHODS: The experiment was conducted at the Laboratory of Acupuncture and Moxibustion, Beijing University of Chinese Medicine from January to July in 2001. ①The normal cavies were bred at normal conditions, while other cavies were injected intramuscularly with 80 mg/kg gentamicin every day, continuously for 20 days. At the same time of gentamicin injection, Yifeng (SJ 17), Ermen (SJ 21) and Zhongzhu (SJ 3) were selected for acupuncture treatment in the corresponding groups. The fixed cavies were pricked subcutaneously with 0.35 mm×25 mm stainless steel acupuncture needles for 10 mm straight depth. The needles were twisted with mild reinforcing-reducing method once in half a minute, repeated every 10 minutes, and remained for 30 minutes one day for 20 days.②Before and after the intervention, auditory brain-stem response (ABR) was detected with 7S11A evoked potential apparatus, in which the sound source was input by earphone for measuring the threshold value of ABR in cavies. ③The difference of measurement data were compared with t test between groups.MAIN OUTCOME MEASURES: The effect of acupuncture treatment at Yifeng (SJ 17), Ermen (SJ 21) and Zhongzhu (SJ 3) on the ABR threshold in cavies injured by gentamicin.RESULTS: Totally 60 cavies were involved in the result analysis. There was insignificant difference in the ABR threshold of each group before the intervention (P > 0.05); After the intervention, the ABR threshold was obviously lower in normal group than in other 4 groups (P < 0.01), and also obviously lower in 3 acupuncture groups than in model group (P< 0.01),and especially in Yifeng group than in model group.CONCLUSION: The acupuncture treatment at Ermen (SJ 21), Zhongzhu (SJ 3), and especially at Yifeng (SJ 17) acupoints can relieve the hearing impairment in the cavies due to drug toxicity.
4.Relationship between T354P mutation of the human sodium/iodine symporter and congenital hypothyroidism.
Zhen ZHAO ; Sheng-li YAN ; Ping FU
Chinese Journal of Pediatrics 2004;42(6):456-457
Case-Control Studies
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Child, Preschool
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Congenital Hypothyroidism
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DNA
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genetics
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Female
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Humans
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Hypothyroidism
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genetics
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Infant
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Iodine
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metabolism
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Male
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Mutation
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Polymerase Chain Reaction
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Sodium
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metabolism
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Symporters
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genetics
5.Evaluation of Chinese cobra venoms in preventing the kidney from ischemia/reperfusion injury
Chinese Journal of Nephrology 2005;0(08):-
Objective To investigate the renal protection of Chinese cobra venoms (CCV) and its mechanism in renal ischemia/reperfusion (I/R). Methods Thirty-two rats were divided into four groups. 0.1% CCV was separately infused into abdominal cavity at 0.5 h, 24 h before reperfusion in group Ⅰ and Ⅱ . Group Ⅲ suffered from kidney I/R was served as pathological control. Group Ⅳ was sham operation group. BUN and Scr were measured before ischemia and 24 h after reperfusion. Complement C3 was observed at 0, 0.5, 2, 24 h after reperfusion. The kidney samples were examined by HE stain under light microscopy. Apoptosis was detected by terminal deoxynucleotidyl transferase mediated dUTP-biotin in situ nick-end labeling(TUNEL). Results Significant histological damage, apoptosis of tubular cell and impaired renal function were found in group Ⅰ and Ⅲ.The above indexes decreased to a less extend in group Ⅱ (P
6.Effects of Glucagon Peptide-1 on Blood Pressure Variability in Diabetic Hypertensive Patients
Shaoqing WANG ; Li ZANG ; Li WANG ; Fang GAO ; Ping FU
Tianjin Medical Journal 2014;(8):790-792
Objective To investigate the role of glucagon peptide-1(GLP-1) in blood pressure variability (BPV) in diabetic hypertensive patients. Methods A total of 120 diabetic hypertensive patients were included in this study. GLP-1 was used for the treatment. The values of body mass index (BMI), fasting blood glucose, glycosylated hemoglobin, creatine and 24-hour ambulatory blood pressure (BP) monitoring were detected before and after treatment with GLP-1 for six months. The clinical indices were compared before and after treatment. Results The values of fasting blood glucose (mmol/L:7.12± 0.64 vs 9.19±2.78), glycosylated hemoglobin (%:7.00±0.14 vs 8.28±1.32) and BMI (kg/m2:19.30±3.24 vs 24.5±4.53 ) were de-creased to the normal level after GLP-1 treatment for six months (P<0.05). There were significant decrease in the 24-h sys-tolic BP (mmHg:135.02 ± 16.57 vs 139.52 ± 15.60), daytime systolic BP (mmHg:132.5 ± 14.6 vs 136.44 ± 14.24), 24-h systolic BP variability (mmHg:12.20 ± 1.44 vs 12.73 ± 1.66), daytime systolic BP variability (mmHg:11.11 ± 1.48 vs 11.74 ± 1.52 ), and daytime diastolic BP variability (mmHg:7.03±1.42 vs 7.43±1.45) after GLP-1 treatment for six months (P<0.05). Conclu-sion GLP-1 can decrease BPV in diabetic hypertensive patients.
7.Clinical application of stereotactic radiotherapy in treatment of lung cancer
Dezhi LI ; Ping PU ; Shangzhi FU ; Qiming LI ; Yuping ZHANG
Journal of Third Military Medical University 2001;23(4):473-475
Objective To study the indication, contraindication and short-term clinical effects of stereotactic radiotherapy (X-knife) in lung cancer. Methods A total of 56 cases (Treatment group) of lung cancer were treated with X-knife composing of the modern 3-D treatment planning system and the stereotactic body frame, and SL-75 accelerator. And another 53 cases only treated with routine external radiation served as the control. In treatment group, 42 cases received 50 Gy radiation, at 2 Gy per day, 5 d per week in the upper mediastinum, hilus of lung, below the primary focus first and then underwent X-knife for the primary focuses, and other 14 recurrent and metastatic cases received irradiation of 8-12 Gy per day, 5 d by X-knife alone. Results The actually reexamination rate for 1, 3, 6, and 12 months after X-knife treatment in 78 focuses from 56 cases was 79.5% (62/78), 89.8% (70/78), 87.2% (68/78) and 78.2% (61/78) respectively. The focuses reappeared in 3 months after the treatment and the growth rates of focus in 3, 6, and 12 month after the treatment were 2.6% (2/78), 5.1% and 9% (7/78) respectively. There were 2 focuses received a second treatment with X-knife because no change after the first one. Both the 1-and 2-year survival rates of 36 cases of the primary lung cancer in the treatment group were higher than that of control group (89.1%, 53.9% and 77.4%, 39.6%). Conclusion The stereotactic radiotherapy is of applicable and prospective in the treatment of lung cancer. The indications include: ①As a boost dose in case when primary focus is less than 5 cm after the first external radiotherapy may reduce the exposure of lung tissue to x-ray and the occurrence of radiation pneumonia; ②Treatment for the recurrence after radiotherapy and operation; ③Radical treatment for the metastatic focus less than 5 cm. Attention must be paid to when multiple treatment is carried on the volume of the focus, the Karnofsky scores and the general condition when stereotactic radiotherapy combined with X-knife for lung cancer.
8.Multi-slice CT Reconstruction in the Diagnosis of Intracranial Foreign Bodies
Li-ping WANG ; Bin SHAO ; Xiao-fu LI
Chinese Journal of Rehabilitation Theory and Practice 2006;12(4):339-340
ObjectiveTo evaluate the role of multi-slice CT(MSCT) reconstruction in the diagnosis of intracranial foreign bodies.MethodsMSCT scans were performed in 16 patients with intracranial foreign bodies. The volumetric data were reconstructed in the workstation. 5 patients were detected by CT angiography (CTA) examination. Imaging results were then compared with findings found during surgery.Results11 foreign bodies located in one brain lobe, 3 passed two brain lobes, 2 located in ventricle. Among them, 6 cases were closed to parietal including 2 cases closed to cerebral arterial circle. 14 patients were operated and extirpated 18 foreign bodies. Compared with surgical findings, the orientative accuracy of reconstruction imaging was 100%, qualitative accuracy was 85.7%.ConclusionMSCT reconstruction may display the intracranial foreign bodies from multi-angles. It is propitious to know the characteristics, location and whole shape of the foreign bodies for the surgeon before the operation, accordingly to make a best operation project.
9.Squamous cell nodules in the thyroid: report of a case.
Yan-biao FU ; Bai-zhou LI ; Ping WANG
Chinese Journal of Pathology 2013;42(1):53-54
Carcinoma, Mucoepidermoid
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complications
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metabolism
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pathology
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DNA-Binding Proteins
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metabolism
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Diagnosis, Differential
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Eosinophilia
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complications
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metabolism
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pathology
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Epithelial Cells
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pathology
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Female
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Hashimoto Disease
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metabolism
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pathology
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surgery
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Humans
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Keratin-19
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metabolism
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Membrane Proteins
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metabolism
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Middle Aged
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Thyroid Gland
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metabolism
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pathology
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surgery
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Thyroid Nodule
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metabolism
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pathology
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surgery
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Transcription Factors
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beta Catenin
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metabolism
10.Expression of synapsin in visual cortex of developing mice
Qing, SU ; Song, HAN ; Ping, XI ; Junfa, LI ; Tao, FU
Chinese Journal of Experimental Ophthalmology 2014;32(5):388-391
Background The treatment timing and method of amblyopia rely on the plasticity of visual system.Synapsin is a family of presynaptic terminal specific protein.Its role in visual developmental plasticity is below understood.Objective To investigate the dynamic expressions of synapsin (T-synapsin),and phosphorylation of synapsin (p-synapsin Ⅰ a/b) in visual cortex of normal mice and further explore the role of synapsin in plasticity of visual system.Methods Forty-two clean neonatal C57BL/6 mice were collected.The mice were sacrificed at postnatal 7,14,21,28,35,42,60 days respectively to obtain the tissue samples of visual cortex.Expression levels of T-synapsin and p-synapsin in the visual cortex following the ageing were quantitatively detected using Western blot assay.Results The expression of synapsin in normal mice showed a dynamic increase with the ageing.The T-synapsin Ⅰ a/b/β-actin value in visual cortex was (21.32 ± 3.27) %,(56.27 ± 10.18) %,(77.05 ± 10.05) %,(83.75±10.52) %,(94.69±11.46)%,(98.75±5.86) % of adults mice (postnatal 60 days,P60) in the mice of postnatal 7,14,21,28,35,42 days,respectively,showing a significant difference among them (F =69.538,P < 0.001).Compared with the adult mice,the T-synapsin Ⅰ a/b/β-actin value in the mice of P7,P14,P21,P28 was significantly lower (all at P<0.05),but no significant difference was found between P35 and P60,P42 and P60 (P =0.280,0.798).The development trend of different synapsin subtypes,such as T-synapsin Ⅰ a/b,T-synapsin Ⅱ a,T-synapsin Ⅱ b and T-synapsin Ⅲ a,was not quite the same during the ageing.The expression of T-synapsin Ⅱ a and Ⅲ a increasing more slowly with development,and kept increasing until P60.Significant differences were found among various age of mice in T-synapsin Ⅱ a,Ⅱ b,Ⅲa respectively(F =42.492 55.595,39.172,all at P<0.001).The p-synapsin Ⅰ a/b level in the visual cortex elevated with the ageing of the mice,and that peaked in P21 mice,which was (2.86±0.17) times more than that in adult mice.After that,the expression level of p-synapsin Ⅰ a/b dropped rapidly.A significant difference was found in the p-synapsin Ⅰ a/b expression among different ages of mice (F =22.620,P < 0.001).Conclusions Synapsin level in visual cortex presents a developmental change which correlated with the onset and decline of the critical period.Synapsin is probably involved in the regulation of neural plasticity in visual cortex in critical period.