1.Application of zebra fishes in studies on traditional Chinese medicines.
China Journal of Chinese Materia Medica 2015;40(5):822-827
The zebra fish model, as an integral animal model, features small volume, high throughput, low cost, short cycle and reliable experimental results, thus has been widely used in medical studies. Traditional Chinese medicines (TCM) constitute a complex system, their active ingredients and action mechanisms are among study hotspots in during the development of modern TCMs. Along with the constant improvement of advanced technologies and methods, zebra fishes have been increasingly applied in studies on TCMs and shown advantages in active screening, and toxicity and metabolism studies. In this paper, TCM studies by using zebra fishes in recent years are summarized to provide new ideas and methods for basic studies on TCMs.
Animals
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Drugs, Chinese Herbal
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pharmacology
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Medicine, Chinese Traditional
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Models, Animal
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Zebrafish
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genetics
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growth & development
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metabolism
2.Role of Cripto-1 protein in development and target therapy of breast cancer.
Ting LEI ; Xiao-jing GUO ; Li FU
Chinese Journal of Pathology 2010;39(1):66-68
Animals
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Antibodies, Monoclonal
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metabolism
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therapeutic use
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Biomarkers, Tumor
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metabolism
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Breast Neoplasms
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metabolism
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pathology
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therapy
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Drug Delivery Systems
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Epidermal Growth Factor
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immunology
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metabolism
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physiology
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Epithelial-Mesenchymal Transition
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GPI-Linked Proteins
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Humans
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Immunotherapy
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methods
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Intercellular Signaling Peptides and Proteins
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Membrane Glycoproteins
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immunology
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metabolism
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physiology
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Neoplasm Invasiveness
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Neoplasm Metastasis
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Neoplasm Proteins
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immunology
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metabolism
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physiology
3.Persistent Pursuit in Research of Artemisinin: Fast Elimination of Malaria Commemoration for the 50th Anniversary of Project 523
Guoqiao LI ; Xingbo GUO ; Linchun FU
Journal of Guangzhou University of Traditional Chinese Medicine 2017;34(3):303-307
At the 50th Anniversary of Project 523,we reviewed the course and progress made by the Artemisinin Anti-malaria Research Group of Guangzhou University of Chinese Medicine in the application of artemisinin for treating malaria.As one of the groups participating in the mission of Project 523,Artemisinin Anti-malaria Research Group of Guangzhou University of Chinese Medicine was in charge of the clinical trials in treating malaria with artemisinin and its derivatives of various preparation forms,dosages and treatment courses(years 1974-1989),developed the artemisinin-based combinations(ACTs) Artekin and Artequick for malaria treatment and performed their clinical trials(years 1984-2006).For the recent 10 years,the group has been devoted in the implementation of anti-malaria programme FEMSE (Fast Elimination of Malaria by Source Eradication) in south-east Asia and Africa.The scientific explorations and achievements of this research group have made great contribution in bringing artemisinins to the world and creating a simple,practical and cost-effective new method for rapid global malaria elimination.
4.Adenosine and the anti-epileptic actions of ketogenic diets.
Chinese Journal of Pediatrics 2012;50(12):903-905
5.The correlation of Galectin-3 gene polymorphism and breast cancer
Huilan LI ; Shuai LI ; Lili ZHAI ; Xiaojing GUO ; Li FU
Journal of Endocrine Surgery 2014;(2):105-108
Objective To investigate the association of Galectin-3 ( lectin, galactoside-binding soluble , LGALS3)gene-191(rs4644)polymorphism and breast cancer in Chinese female population .Methods Galectin-3 gene rs4644 polymorphisms was genotyped by polymerase chain reaction-restriction fragment length polymor-phism(PCR-RFLP)in 172 breast cancer patients and 17 controls.The experimental results of PCR-RFLP were verified and sample of 10 cases were sequenced randomly .Results The frequency of CC ,CA and AA genotype in breast cancer group and normal control group was 72.7%, 25.0%, 2.3% and 52.9%, 41.2%, 5.9%, respectively .The frequency of C and A allele in breast cancer group and normal control group was 85.2%, 14.8%and 73.5%, 26.5% respectively .The genotype and frequency of allele had no statistical difference between breast cancer patients and the control group .rs4644C allele was more likely to occur in breast cancer patients with T>2 cm (χ2 =8.295,P=0.004) and Ki67<14%(χ2 =3.917,P=0.048).Conclusions There is no significant association between Galectin-3 gene 191 polymorphism rs4644 and susceptibility of breast cancer in Chinese female population .It is closely associated with the size of tumor and Ki 67.
6.Primary pulmonary invasive carcinoma ex pleomorphic adenoma: report of a case.
Bai-zhou LI ; Yan-biao FU ; Guo-feng WANG
Chinese Journal of Pathology 2012;41(1):54-54
Adenoma, Pleomorphic
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metabolism
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pathology
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surgery
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Aged
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Carcinoma
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metabolism
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pathology
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surgery
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Cell Transformation, Neoplastic
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Humans
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Lung Neoplasms
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metabolism
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pathology
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surgery
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Male
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Mucin-1
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metabolism
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S100 Proteins
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metabolism
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Vimentin
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metabolism
7.Application and research on on-line editing system of ancient TCM books
Minhua GUO ; Yongchi FU ; Weina ZHANG ; Bin LI
International Journal of Traditional Chinese Medicine 2011;33(12):1093-1095
Objective To enhance and improve the accuracy of data,security of system and user friendliness of on-line editing system processing ancient TCM books.Methods Web and java technology were applied to implement and demonstrate the key algorithm.Results In these solutions,pictures could be watermarked,on-line editing was supported,picture-naming was standardized with 7-characters,multi-user on-line editing was available,etc.The ancient TCM books on-line editing system became more practical,effective and user-friendly.Conclusion The solutions mentioned above have achieved the expected effects in digitalization research of ancient TCM books,showing its feasibility and practicability.
8.Synovial sarcoma of tongue: report of a case.
Yan-biao FU ; Guo-feng WANG ; Bai-zhou LI
Chinese Journal of Pathology 2010;39(8):557-558
Glossectomy
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methods
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Humans
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In Situ Hybridization, Fluorescence
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Keratins
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metabolism
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Male
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Middle Aged
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Oncogene Proteins, Fusion
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genetics
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Sarcoma, Synovial
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genetics
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metabolism
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pathology
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surgery
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Tongue Neoplasms
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genetics
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metabolism
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pathology
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surgery
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Translocation, Genetic
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Vimentin
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metabolism
9.The Relationship Between N-Terminal Pro-B-Type Natriuretic Peptide and the Coronary Artery Disease in Patients with Stable Angina Pectoris and Diabetes
Xin FU ; Zhenwen HUANG ; Feifei ZHANG ; Li GUO
Chinese Journal of Hypertension 2007;0(01):-
75%(more than 2-vessel disease) and 50 persons with angia and non-diabetes were selected as control.Results The level of NT-proBNP was significantly higher in stable angina patients with diabetes(750?80 ng/L) than that in stable angina patients without diabetes(450?75 ng/L)(P
10.Early diagnostic value of MRI for intraductal papilloma of the breast
Baoqin GUO ; Hua LI ; Yi CHEN ; Hao LIU ; Juan FU
Journal of Practical Radiology 2016;32(10):1539-1541,1581
Objective To analyze MRI features of breast intraductal papilloma,to improve the acquaintance of this disease.Methods The preoperative MRI images (T2 WI-SPAIR,DWI,ADC,TIC and MIP)of eight patients with breast intraductal papilloma confirmed by surgery were reviewed retrospectively,which were compared with the postoperative pathology.The morphology,distribution, enhanced methods and signal characteristics of the lesion were summarized.Results Of 8 cases,the lession was dormant,and MRI revealed three patterns:the first type was occult papilloma,which presented distention of ducts and no solid nodule in 3 cases (37.5%);the second type showed tiny nodules in bar-like dilatation of ducts in 3 cases (37.5%);and the third type presented small round nodules scattering distribued in terminal ductules in 2 cases (25%).The maximum diameter of nodular lesions was 0.4-1.0 cm(average 0.7 cm).The lesions on T2 WI-SPAIR showed equal signal intensity or mixed signals with isointensity/hypointensity,and dilatation catheter.enhancement. The ADC and TIC value were various,therefore,diagnosis of the tumor should be combined with morphology and associated symptoms. Conclusion At early stage,the occult focus of breast intraductal papilloma can be sensitively detected and localized on MRI.It reveals that MRI has advantage in showing morphology of lesion and functional imaging,which is of important value in clinical diagnosis and early treatment.