Objective To observe the clinical efficacy of deep needling with long needles plus electroacupuncture in treating lower-limb pain due to lumbar intervertebral disc herniation (LIDH).Method Totally 139 patients with lower-limb pain due to LIDH were randomized into a treatment group of 76 cases and a control group of 63 cases. The treatment group was intervened by stimulating spinal nerve by deep needling with long needles (75 mm) plus electroacupuncture, while the control group was by conventional needling plus electroacupuncture. The Visual Analogue Scale (VAS) was observed before and after intervention, and the clinical efficacies were compared between the two groups.Result The total effective rate was 80.3% in the treatment group versus 57.1% in the control group, and the difference was statistically significant (P<0.05). The VAS scores were significantly changed after intervention in both groups (P<0.05). After intervention, there was a significant difference in comparing the VAS score between the two groups (P<0.05).Conclusion Deep needling with long needles plus electroacupuncture is an effective method in treating lower-limb pain due to LIDH.

Objective To systematically analyze the effect of adjuvant chemotherapy after radical operation in advanced gastric cancer .Methods The related literatures published at home and abroad were retrieved from the electronic databases including CNKI ,PubMed ,Elsevier ,Springer ,Oxford from January 2003 to December 2013 ,then 11 articles of the randomized controlled trial (RCT) of the comparison between the postoperative adjuvant chemotherapy and simple operation were collected .The effect merging and the quantitative systematic evaluation in the aspects of the total survival ,disease free survival and relapse free survival were per-formed with RevMan5 .2 provided by the Cochrane collaboration network .Results 11 articles of RCT were included with 4 points and more by the Jadad scale ,involving 4 433 patients ,among them 2 203 patients with operation plus postoperative chemotherapy and 2 230 patients with surgery alone .The results analysis indicated that the postoperative adjuvant chemotherapy made the pa-tients to obtain the apparent benefit during survival period ,the significant difference had statistical significance .OS :HR= 0 .80 , 95% CI(0 .73 ,0 .88) ,P<0 .01 ;DFS :HR=0 .78 ,95% CI(0 .63 ,0 .97) ,P=0 .02 ;RFS :HR=0 .67 ,95% CI(0 .53 ,0 .85) ,P=0 .001 . Conclusion The postoperative adjuvant chemotherapy can make the patients with radical operation to obtain the apparent benefit during the survival period .The adjuvant chemotherapy of oral capecitabine plus oxaliplatin or oral Tegafur Gimeracil Oteracil Potas-sium after D2 radical operation may be the best scheme at present .

Animals ; Botulinum Toxins ; adverse effects ; therapeutic use ; Bruxism ; drug therapy ; Dystonia ; drug therapy ; Humans ; Joint Dislocations ; drug therapy ; Sialorrhea ; drug therapy ; Temporomandibular Joint Disorders ; drug therapy

Benzene ; poisoning ; Humans ; Leukemia ; chemically induced

Surgical approaches for esophageal carcinoma are many and varied. Minimally invasive techniques are increasingly used widely in esophagectomy as they not only ensure patients' therapeutic effects, but also reduce trauma and accelerate recovery. The lymph nodes excisional area of esophageal carcinoma is still in controversy. It is necessary to carry out further researches on selective lymph nodes excision, which can decrease complication rate and improve patients' survival in the meantime.
Esophageal Neoplasms ; surgery ; Esophagectomy ; methods ; Humans ; Lymph Node Excision ; methods ; Minimally Invasive Surgical Procedures

Objective To investigate the specific expression of nucleolin in the development of cap-stage tooth germ of mouse embryo,and detect the possible biological function of nucleolin. Methods In situ hybridization and immunohistochemistry were performed to detect the expression of nucleolin mRNA and protein in the development of tooth germ at embryo day 15(E15).Double staining for apoptotic cells and nucleolin was employed to explore the relationship between nucleoin and apoptosis in tooth germ. Results The expression of nucleolin mRNA and protein was mainly detected in the cervical loop,inner epithelium and the underlying dental papilla.Moreover,nucleolin protein was also located in the primary enamel knot and basement membrane.It was revealed by double staining that the fluorescence images of nucleolin and the location of apoptotic cells were not overlapped. Conclusion The expression pattern of nucleolin mRNA do not completely coincide with that of nucleolin protein at the cap stage of tooth germ.The location for nucleolin protein in the basement membrane suggests that nucleolin may be involved in the reciprocal interactions between the inner epithelium and dental papilla mesenchyme,subsequently affect the morphogenesis of tooth germ.

ObjectiveTo investigate the effect of Naoxueshu oral liquid on cerebral hemorrhage caused by hypertension. Methods140 patients with cerebral hemorrhage were randomly dividied into two groups with a 1∶1 ratio,treatment group and control group. Patients in treatment group received Naoxueshu oral liquid 30 ml daily,while that in control received Naoxuekang oral liquid 30 ml daily. The changes of score on Chinese medical integration,National Institutes of Health (NIH) Stroke scale and the volume of intracranial hemorrhage were evaluated before and a month after treatment.ResultsThe decrease of NIH score of patients in treatment group was (12.73±3.94),but(4.72±3.01) with the control's (t=13.5327,P<0.001). The decrease of the volume of intracranial hemorrhage of patients in treatment group was (13.28±4.17) ml,but (8.37±7.24) ml with the control's(t=4.9228,P<0.001). ConclusionComparing with Naoxuekang,Naoxueshu can accelerate absorption of hematome and ameliorate the recovery of neurological disability more efficiently.

Objective To observe the immunologic function of critically ill newborn and the relative function of nuclear factor kappa B(NF-?B).Methods The critically ill group contained 50 cases,and 25 cases from healthy newborns were used as control group.Blood samples were collected in each case,levels of cytokine interleukin(IL)-4,interferon(IFN)-?,tumor necrosis factor(TNF)-? and NF-?B were detected.Result Compared with control group,NF-?B of the critically ill newborn activated and the cytokine were disorder,and IL-4 and TNF-? increased,but IFN-? decreased.Conclusions Critically ill newborn exist immune functional disorder.Furthermore,NF-?B activation may be involved in the process in infants with critically illness.

BACKGROUND: Conservative treatment receives poor results in treating humeral intercondylar fractures,due to the over-long time fixation,and the recovery of joint function would be restricted.Early functional exercises should be based on stable internal fixation.OBJECTIVE: To explore the effectiveness of bone plate internal fixation in treating humeral intercondylar fractures under AO principle.METHODS: Totally 37 cases with humeral intercondylar fractures at the Department of Orthopaedics,Laibin People's Hospital from June 2000 to November 2005 were collected,under AO/ASIF classification,cases were assigned into three groups: type C1consisted of 11 cases,C2 consisted of 21 cases and C3 comprised 5 cases.All the cases were treated by olecranon osteotomy medial approach open reduction and then treated with dual anatomical plate internal fixation.Flexion and extension activities were done at 1 day after operation.Physical therapy was performed at 1 day after removing drainage.According to the images and clinical follow-up,slightly resistance exercise could be done at 4 weeks after operation,and gradually increased the load after8-12 weeks.RESULTS AND CONCLUSIONS: A total of 36 patients were included in the follow-up with 13-26 months,mean 19.5 months.All the bone fractures were recovered.Earlier operative reduction and exercise function would got better elbow joint recovery.All results demonstrated that dual anatomical plate treatment under AO principle provides firm internal fixation for patients with humeral intercondylar fractures,which is good for early exercise and functional recovery.

Thioredoxin-related protein 14 (TRP14),a new member of Trx family,is a novel disulfide reductase with conservative CPDC motif.Its structure and function are comparable to Trx,which is the representative member of Trx family.However,there are many differences.When tumor necrosis factor-α (TNF-α) induced cells to produce the active oxygen,TRP14 can change oxidatin state of dynein light chain(its substrate),act as a sensor of the intracellular redox state to regulate NF-κB signaling pathways induced by TNF-α,MAPK and apoptosis signaling pathways.