4.Malignant melanoma of the back metastatic to thyroid gland: report of a case.
Cheng-lin FU ; Xian-tu ZHANG ; Jin-na ZHANG
Chinese Journal of Pathology 2011;40(2):121-122
Aged
;
Back
;
Carcinoma, Medullary
;
metabolism
;
pathology
;
Diagnosis, Differential
;
Female
;
Humans
;
Melanoma
;
metabolism
;
pathology
;
secondary
;
surgery
;
Melanoma-Specific Antigens
;
metabolism
;
S100 Proteins
;
metabolism
;
Skin Neoplasms
;
metabolism
;
pathology
;
surgery
;
Thyroid Neoplasms
;
metabolism
;
pathology
;
secondary
;
surgery
5.Formalin-induced pain stimulation induced expression of GABA in the distal cerebrospinal fluid contacting neurons.
Cheng-lei CHAO ; Xian-fu LU ; Li-cai ZHANG
Chinese Journal of Applied Physiology 2010;26(1):36-38
Animals
;
Brain
;
cytology
;
Cerebrospinal Fluid
;
physiology
;
Formaldehyde
;
administration & dosage
;
toxicity
;
Inflammation
;
chemically induced
;
physiopathology
;
Male
;
Neurons
;
metabolism
;
physiology
;
Pain
;
chemically induced
;
physiopathology
;
Pain Measurement
;
methods
;
Rats
;
Rats, Sprague-Dawley
;
gamma-Aminobutyric Acid
;
metabolism
6.Seeking the Truth by Combining Chinese medicine and Western Medicine Elements-Ten-year Academic Annual Summary of the Founding of Fujian Institution of Integrative Medicine.
Song-Fu ZHANG ; Qiao-yan CAI ; Xian-xiang LIU
Chinese Journal of Integrated Traditional and Western Medicine 2016;36(3):384-384
8.Study on the role of oxidative stress in the kidneys of diabetic rats
Xiaobo LI ; Zhongqing MU ; Li CHEN ; Yiling FU ; Yan ZHANG ; Yuxin XIAN ; Xinguo HOU
Chinese Journal of Pathophysiology 1986;0(04):-
AIM: To investigate the changes of oxidative stress in the kidneys and their roles in nephropathy in diabetic rats. METHODS: Diabetic rats were induced by streptozotocin (STZ). 36 rats were divided into three groups randomly: (1) NC group, normal control rats; (2) DM group, diabetic rats received protamine zinc insulin (PZI) 2U-4U/2 d; (3) DT group, diabetic rats received PZI 9-12 U/kg body weigh/day. 12 weeks later, rats were killed, blood glucose, blood cholesterol, serum creatinine, blood urea nitrogen, HbA1c, urinary creatinine, and urinary protein for 24 h were measured. The activities of antioxidant enzymes in renal cortex, including total superoxide dismutase (TSOD), Cu-Zn superoxide dismutase (Cu-Zn SOD), Mn superoxide dismutase (Mn SOD), catalase (CAT), glutathione peroxidase (GSH-Px), and maleic dialdehyde (MDA) were measured by chromatometry. RT-PCR was performed to detect the expression of different antioxidant enzymes mRNA. RESULTS: For all the targets we measured, there was no significant difference between NC and DT groups. Compared with the other two groups, the levels of blood glucose, cholesterol, trigalloyl glycerol, HbA1c in DM group increased significantly. The activities of TSOD, Cu-Zn SOD and CAT decreased significantly. The activity of GSH-Px increased significantly. There was no significant difference among the activities of Mn SOD in all three groups. The level of MDA in DM group was much higher than that in NC or DT group. The relative expression levels of GSH-Px and Cu-Zn SOD mRNA in DM group were higher than those in other two groups, while the relative expression level of CAT decreased. Mn SOD mRNA was expressed without significant difference in all groups. Compared with NC or DT group, urinary protein in DM group increased significantly, while creatinine clearance rate decreased. CONCLUSIONS: Hyperglycemia affected the expression of antioxidant enzymes. Oxidative stress was caused by hyperglycemia in diabetic rats and may be an important factor in the etiology of diabetic nephropathy.
9.Radiological examinations and diagnosis of labyrinthitis
Zhengyu ZHANG ; Zhenchang WANG ; Junfang XIAN ; Lin FU ; Liyan HE ; Jian GUO
Chinese Archives of Otolaryngology-Head and Neck Surgery 2006;0(03):-
OBJECTIVE To investigate the radiological findings of labyrinthitis and evaluate the diagnosis value of HRCT and MRI. METHODS The HRCT and MR images of 27 cases ( 31 ears) with labyrinthitis,suggested by clinical examinations and abnormal changes on images coexisting,were studied. RESULTS In the 22 ears which underwent HRCT examinations,6 ears showed increase of the density of one or more structures of inner ear,8 ears showed increase of the density of structure as well as change of the shape of the inner ear,1 ear showed change of the shape only. Labyrinth inner cavity appeared local or total sclerosis and disappearance in 7 ears. Among the 22 ears,there was bony incompleteness in 4 besides the changes mentioned above. In the 9 ears which accepted HRCT and MR scanning,7 ears showed abnormal changes of different degree in the inner ear on HRCT images and the other 2 appeared normal. On MR images,all 9 ears showed decrease or disappearance of the signal of T2WI in one or more structures of membranous labyrinth. Among the 6 ears which performed contrast scanning,markedly enhancement was seen in 4 and no enhancement in 2 ears. Of all the 31 ears,cochlea was involved in 30,of which only basal turn involved in 5,upper and second turns in 2 and all turns in 23,semicircular canal involved in 26,vestibule in 20,oval window in 18 and round window in 19. CONCLUSION HRCT can demonstrate the abnormal changes of bony labyrinth,and MRI is helpful to detect the changes of labyrinth inner cavity. They have important value in the detection and diagnosis of labyrinthitis.
10.Hemodynamic factors to stabilize cerebral blood flow within limits of cerebral autoregulation
Wenjun WANG ; Qingchun GAO ; Jianwen CHEN ; Jian GUO ; Weijin ZHANG ; Xian FU ; Xianliang LI
Chinese Journal of Nervous and Mental Diseases 2016;42(1):1-5
Objective To investigate the hemodynamic parameters to stabilize cerebral blood flow within limits of cerebral autoregualtion. Methods We assessed the flow velocity of middle cerebral artery using transcranial Doppler and recorded invasively the blood pressure simultaneously. We then analyzed the curves of cerebral blood flow autoregulation (CBFA) and calculated upper limit of autoregulation (ULA) and lower limit of autoregulation (LLA). The values of critical closing pressue (CCP) and resistance area product (RAP) were calculated according to previous theory. The relationship between CCP, RAP and MABP were analyzed. Results In the process of increasing or decreasing blood pressure, ULA and LLA of normal rats were 148.12 ± 7.49 mmHg or 62.96 ± 3.34 mmHg, respectively. When mean artery blood pressue (MABP) changed within limits of cerebral autoregulation, the cerebral blood flow velocity changed little (increasing:0.65± 0.27 cm/s/10mmHg MABP, decreasing:0.43±0.23cm/s/10 mmHg MABP), while CCP and RAP changed significantly (in?creasing: 4.60 ± 1.06 mmHg/10mmHg MABP and 0.11 ± 0.04/10 mmHg MABP, decreasing: 6.74 ± 0.59 mmHg/10 mmHg MABP and 0.09 ± 0.02/10mmHg MABP). After fixing change of blood flow velocity, CCP and RAP were correlated with MABP more remarkablely, although all blood flow velocity, CCP and RAP were significantly correlated with MABP. Conclusion Within limits of cerebral autoregulation, stable cerebral blood flow is mainly achieved by the change of CCP and RAP against blood pressure changing on normal rats, especially the increasing or de?creasing of CCP.