1.The Epidemiology and Etiology of Right-Sided Colonic Diverticulosis: A Review
Greg A. TURNER ; Michael J. O’GRADY ; Rachel V. PURCELL ; Frank A. FRIZELLE
Annals of Coloproctology 2021;37(4):196-203
Diverticulosis of the colon is a common condition in Western countries and most patients will remain asymptomatic, but some will present with symptoms of acute diverticulitis or bleeding. Our understanding of diverticulosis is evolving but is mostly derived from diverticulosis affecting the left-sided colon. In contrast, right-sided colonic diverticulosis (RCD) is more commonly seen in Asian countries but is much less common overall. Based on the marked differences in epidemiology, it is commonly thought that these are 2 distinct disease processes. A review of the literature describing the epidemiology and etiology of RCD was performed, with a comparison to the current understanding of left-sided diverticulosis. RCD is becoming increasingly common. The epidemiology of RCD shows it to be a mostly acquired condition, and not congenital as previously thought. Many factors in the etiology of RCD are similar to that seen in left-sided diverticulosis, with a few variations. It is therefore likely that most cases of RCD represent the same disease process that is seen in the left colon.
2.The Epidemiology and Etiology of Right-Sided Colonic Diverticulosis: A Review
Greg A. TURNER ; Michael J. O’GRADY ; Rachel V. PURCELL ; Frank A. FRIZELLE
Annals of Coloproctology 2021;37(4):196-203
Diverticulosis of the colon is a common condition in Western countries and most patients will remain asymptomatic, but some will present with symptoms of acute diverticulitis or bleeding. Our understanding of diverticulosis is evolving but is mostly derived from diverticulosis affecting the left-sided colon. In contrast, right-sided colonic diverticulosis (RCD) is more commonly seen in Asian countries but is much less common overall. Based on the marked differences in epidemiology, it is commonly thought that these are 2 distinct disease processes. A review of the literature describing the epidemiology and etiology of RCD was performed, with a comparison to the current understanding of left-sided diverticulosis. RCD is becoming increasingly common. The epidemiology of RCD shows it to be a mostly acquired condition, and not congenital as previously thought. Many factors in the etiology of RCD are similar to that seen in left-sided diverticulosis, with a few variations. It is therefore likely that most cases of RCD represent the same disease process that is seen in the left colon.
3.A Review of the Role of Carcinoembryonic Antigen in Clinical Practice
Claire HALL ; Louise CLARKE ; Atanu PAL ; Pamela BUCHWALD ; Tim EGLINTON ; Chris WAKEMAN ; Frank FRIZELLE
Annals of Coloproctology 2019;35(6):294-305
Carcinoembryonic antigen (CEA) is not normally produced in significant quantities after birth but is elevated in colorectal cancer. The aim of this review was to define the current role of CEA and how best to investigate patients with elevated CEA levels. A systematic review of CEA was performed, in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Studies were identified from PubMed, Cochrane library, and controlled trials registers. We identified 2,712 papers of which 34 were relevant. Analysis of these papers found higher preoperative CEA levels were associated with advanced or metastatic disease and thus poorer prognosis. Postoperatively, failure of CEA to return to normal was found to be indicative of residual or recurrent disease. However, measurement of CEA levels alone was not sufficient to improve survival rates. Two algorithms are proposed to guide investigation of patients with elevated CEA: one for patients with elevated CEA after CRC resection, and another for patients with de novo elevated CEA. CEA measurement has an important role in the investigation, management and follow-up of patients with colorectal cancer.
Carcinoembryonic Antigen
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Colorectal Neoplasms
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Follow-Up Studies
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Humans
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Parturition
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Prognosis
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Recurrence
;
Survival Rate
4.Toward more uniform conflict disclosures: the updated ICMJE Conflict of Interest Reporting Form.
Jeffrey M DRAZEN ; Peter W de LEEUW ; Christine LAINE ; Cynthia MULROW ; Catherine D DEANGELIS ; Frank A FRIZELLE ; Fiona GODLEE ; Charlotte HAUG ; Paul C HÉBERT ; Astrid JAMES ; Sheldon KOTZIN ; Ana MARUSIC ; Humberto REYES ; Jacob ROSENBERG ; Peush SAHNI ; Getu ZHAORI
Chinese Medical Journal 2010;123(13):1621-1622
5.Data Sharing Statements for Clinical Trials: A Requirement of the International Committee of Medical Journal Editors.
Darren B TAICHMAN ; Peush SAHNI ; Anja PINBORG ; Larry PEIPERL ; Christine LAINE ; Astrid JAMES ; Sung Tae HONG ; Abraham HAILEAMLAK ; Laragh GOLLOGLY ; Fiona GODLEE ; Frank A FRIZELLE ; Fernando FLORENZANO ; Jeffrey M DRAZEN ; Howard BAUCHNER ; Christopher BAETHGE ; Joyce BACKUS
Journal of Korean Medical Science 2017;32(7):1051-1053
No abstract available.
Information Dissemination*
6.Sharing Clinical Trial Data: A Proposal from the International Committee of Medical Journal Editors.
Darren B TAICHMAN ; Joyce BACKUS ; Christopher BAETHGE ; Howard BAUCHNER ; Peter W de LEEUW ; Jeffrey M DRAZEN ; John FLETCHER ; Frank FRIZELLE ; Trish GROVES ; Abraham HAILEAMLAK ; Astrid JAMES ; Christine LAINE ; Larry PEIPERL ; Anja PINBORG ; Peush SAHNI ; Si-Nan WU
Chinese Medical Journal 2016;129(2):127-128
7.A Disclosure Form for Work Submitted to Medical Journals: a Proposal from the International Committee of Medical Journal Editors
Darren B TAICHMAN ; Joyce BACKUS ; Christopher BAETHGE ; Howard BAUCHNER ; Annette FLANAGIN ; Fernando FLORENZANO ; Frank A FRIZELLE ; Fiona GODLEE ; Laragh GOLLOGLY ; Abraham HAILEAMLAK ; Sung Tae HONG ; Richard HORTON ; Astrid JAMES ; Christine LAINE ; Pamela W MILLER ; Anja PINBORG ; Eric J RUBIN ; Peush SAHNI
Journal of Korean Medical Science 2020;35(4):39-
No abstract available.
Disclosure
8.A Disclosure Form for Work Submitted to Medical Journals: a Proposal from the International Committee of Medical Journal Editors
Darren B TAICHMAN ; Joyce BACKUS ; Christopher BAETHGE ; Howard BAUCHNER ; Annette FLANAGIN ; Fernando FLORENZANO ; Frank A FRIZELLE ; Fiona GODLEE ; Laragh GOLLOGLY ; Abraham HAILEAMLAK ; Sung Tae HONG ; Richard HORTON ; Astrid JAMES ; Christine LAINE ; Pamela W MILLER ; Anja PINBORG ; Eric J RUBIN ; Peush SAHNI
Journal of Korean Medical Science 2020;35(4):e39-
9.A Randomized Controlled Trial of Mindfulness in Recovery from Colorectal Cancer.
Andrew MCCOMBIE ; Jennifer JORDAN ; Roger MULDER ; Kishion DEE ; Ee Lin ONG ; Fernanda Fernandez ZIMMERMANN ; Chris FRAMPTON ; Frank FRIZELLE
Chinese journal of integrative medicine 2023;29(7):590-599
OBJECTIVE:
This study examined whether a 4-week group-based mindfulness intervention would be superior in reducing psychological distress in colorectal cancer (CRC) patients compared to a psychoeducation and cognitive behavioural skills learning support active control group.
METHODS:
Patients with CRC were randomized via Computerised Permuted Block Randomisation to mindfulness or active control groups (2-h weekly sessions over 4 weeks). Outcomes were measured pre-intervention, and 8 weeks and 6 months post-baseline. The primary outcome was psychological distress measured by the Hospital Anxiety and Depression Scale. Secondary outcomes were generic quality of life (QoL), disease specific QoL, mindfulness, and intervention credibility and acceptability.
RESULTS:
Sixty-eight participants were randomized to mindfulness (n=35) or active control group (n=33). Uptake of potentially eligible patients consenting was low (28.0%) and the dropout rate was 33.8%. Depression scores were reduced in both groups at week 8 (P=0.020). Control participants had greater improvement in generic mental QoL scores at week 8 than mindfulness (P=0.023). In disease specific QoL, there was reduction in impotence symptom in the mindfulness group (P=0.022) and reduction in faecal incontinence in the control group (P=0.019). The embarrassment symptom had a significantly lower increase in the mindfulness group at week 8 compared to the control group (P=0.009). Both groups rated the treatments as credible and acceptable.
CONCLUSIONS
Mindfulness was not superior to the active control group in terms of alleviating psychological distress but both treatments were associated with some improvements in depression. There was low uptake of both interventions. (Trial registration number: ACTRN12616001033437).
Male
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Humans
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Quality of Life
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Mindfulness
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Colorectal Neoplasms/therapy*