1.The subcutaneous capsules for foreign body in fetal rabbits: preliminary report.
Won Jai LEE ; Beyoung Yun PARK
Yonsei Medical Journal 2001;42(6):595-601
In terms of wound healing, there are fundamental intrinsic and extrinsic differences between fetuses (scar-free healing) and adults. The fetus exhibits less typical inflammatory response (signifiquently neutropenic) with an underdeveloped self-nonself immunologic identity and a lack of cellular immunity. The recruitment of inflammatory cells to a wound may play an important role in the resulting cellular processes and ultimately affect the quality of the healing response. Foreign bodies can act as a source of infection and immunologic reactions. In contrast, there have been few studies of the wound healing of fetus with foreign bodies, where in adults, wounds are healed by tissue regeneration rather than capsule formation and a foreign body reaction. In this study, the wound healing process in an adult rabbit and fetus group, in which either silicone or a sponge was inserted in the uterus, were compared. All specimens showed capsule formation with fibroblast, collagen deposition, neovascularization, and infiltration of inflammatory cells. However, the fetal specimen exhibited mainly acute inflammatory responses and the capsule contained less fibroblasts and collagen deposition. In addition, myofibroblast expression, which mediates wound contracture, was lower in the fetal specimen. These findings were common with cotton implants, which were expected to induce a severe inflammatory response. The inflammatory response induced by foreign materials in fetal tissue showed similar response with that of incisional wound healing. This study may provide a basis for the use of implants such as silicone in future fetal surgery.
Aging/physiology
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Animal
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Female
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Fetus/physiology
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Foreign Bodies/pathology/*physiopathology
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Foreign-Body Reaction/pathology/*physiopathology
;
Rabbits
;
Uterus/embryology/*physiopathology
2.Breast Cancer from the Excisional Scar of a Benign Mass.
Min Jung KIM ; Eun Kyung KIM ; Ji Young LEE ; Ji Hyun YOUK ; Byeong Woo PARK ; Haeryoung KIM ; Ki Keun OH
Korean Journal of Radiology 2007;8(3):254-257
Breast cancer developing from a surgical scar is rare; this type of malignancy has been reported in only 12 cases to date. Herein, we report on a 52-year-old female who developed infiltrating ductal carcinoma in a surgical scar following excision of a benign mass. Two years previously, the patient underwent surgery and radiotherapy for invasive ductal carcinoma of the contralateral breast. The initial appearance of the scar was similar to fat necrosis; it was observed to be progressively shrinking on follow-up sonography. On the two year follow-up ultrasound, the appearance changed, an angular margin and vascularity at the periphery of the scar were noted. A biopsy and subsequent excision of the scar were performed; the diagnosis of infiltrating ductal carcinoma of the scar was confirmed.
Breast Neoplasms/*etiology/pathology/surgery
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Carcinoma, Ductal, Breast/*etiology
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Cicatrix/*complications
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Female
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Foreign-Body Reaction/pathology
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Giant Cells/pathology
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Humans
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Middle Aged
;
Papilloma, Intraductal/pathology/surgery
3.Pathologic findings after recession and resection of extraocular muscles in rabbits.
Sung Wook YANG ; Bong Leen CHANG
Korean Journal of Ophthalmology 1989;3(2):75-79
A study on the pathologic findings after recession and resection of extraocular muscles in rabbits was performed. Fibrosis of the extraocular muscles increased with time, which showed no difference between the recessed and resected muscles. Inflammation and foreign body reaction decreased with time, which showed no difference between the recessed and resected muscles. Adhesions of extraocular muscles to the sclera were observed from one month after the operation. The resected muscles showed milder adhesion to the sclera than the recessed ones. The operated extraocular muscles showed atrophies at one month, which showed no difference between the recessed and resected muscles. According to our results, when reoperation is needed, fibrosis of the extraocular muscles after recession and resection should be considered when making a decision on the amount of muscle to be recessed and resected.
Animals
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Atrophy/etiology
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Fibrosis/etiology
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Foreign-Body Reaction/pathology
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Inflammation/etiology/pathology
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Oculomotor Muscles/pathology/*surgery
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Postoperative Complications/*pathology
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Rabbits
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Reoperation
4.Fibrous capsule surrounding silicone encircling band and Gore-Tex(TM) surgical membrane.
Dong Myung KIM ; Sung Min HYUNG
Korean Journal of Ophthalmology 1991;5(2):51-58
Since the anterior chamber tube shunt to an encircling band(ACTSEB) is not a simple procedure, an extended polytetrafluoroethylene (e-PTFE)-silicone tube (anterior chamber tube shunt to a surgical membrane; ACTSSM) was attempted as a new glaucoma drainage implant. To see whether the newly-modified, two-fold e-PTFE-silicone tube implant could prevent early hypotony and to compare the tissue response to each implant, ACTSEB and ACTSSM procedures were done in normal colored rabbit eyes. It was found the ACTSSM kept the depth of the postoperative anterior chamber normal. And in general, foreign body responses were light microscopically similar. The fibrous capsule lining the e-PTFE was composed of thicker, less dense fibroblasts, as well as less collagen than that lining the silicone encircling band. These findings seemed to be related to the difference in the pressure-lowering capacity between ACTSEB and ACTSSM.
Animals
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Anterior Chamber/pathology/*surgery
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Cell Adhesion
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Drainage/*instrumentation
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Fibroblasts
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Foreign-Body Reaction/pathology
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Glaucoma/*surgery
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Intraocular Pressure
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*Polytetrafluoroethylene
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Postoperative Complications/prevention & control
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*Prostheses and Implants
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Rabbits
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*Silicone Elastomers
5.Radiofrequency coblation for treatment of abnormal sensation of throat induced by the hypertrophy of lingual tonsil.
Qingfeng ZHANG ; Cuiping SHE ; Hui WANG ; Yue ZHANG
Journal of Clinical Otorhinolaryngology Head and Neck Surgery 2014;28(3):185-187
OBJECTIVE:
The aim of the present study was to evaluate the effects of radiofrequency coblation surgery for treatment of abnormal sensation of throat induced by the hypertrophy of lingual tonsil.
METHOD:
Three hundred and seven patients affected by abnormal sensation of throat induced by the hypertrophy of lingual tonsil were enrolled. Radiofrequency coblation was performed on all patients under nasal endoscopy. A comprehensive statistics were obtained from all the participants regarding the recovery of wound surface, postoperative pain, intra and postoperative bleeding and the effects of the procedure.
RESULT:
The VAS score of abnormal sensation of throat was reduced from (9.3 +/- 0.6) to (3.7 +/- 2.4) (P<0.05) after the operation. 84.4% of the abnormal sensation dis appeared, no recurrence within six month; 6.8% of the abnormal sensation largely reduced within six month; 4.6% of the abnormal sensation reduced within six month. There was no significant postoperative pain. 3.6% (11/307) of patients experienced postoperative hemorrhage. The follow-up period ranged from 6 to 36 months, there was no recurrence.
CONCLUSION
Radiofrequency coblation is a useful surgical technique, as effective as,or even superior to,other surgical techniques when dealing with patients suffering from abnormal sensation of throat induced by the hypertrophy of lingual tonsil with potentially fewer adverse effects and subsequently improved quality of life for patients.
Adult
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Catheter Ablation
;
methods
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Female
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Foreign-Body Reaction
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etiology
;
surgery
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Humans
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Hypertrophy
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Male
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Middle Aged
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Palatine Tonsil
;
pathology
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Tongue
;
pathology
;
Young Adult
6.Induction of Capsular Island Flap Using Two Silastic Sheets.
Joon Pio HONG ; Hoon Bum LEE ; Sug Won KIM ; Yoon Kyu CHUNG
Journal of the Korean Society of Plastic and Reconstructive Surgeons 1999;26(4):647-651
The search for a new flap with minimal donor morbidity has been pursued by many plastic surgeons. Numerous donor sites available for microsurgical composite tissue transplantation have been described owing to the tremendous advances made in the field of microsurgery. To be suifable for use as a free flap, a sizable vessel must be included within the tissue, leading to significant donor morbidity. There have been studies for prefabrication of an axial pattern flap in an effort to create a new flap, but most of these methods relied solely on revascularization of a preexisting composite tissue. Our experiment, using an isolated femoral artery and vein as the main pedicle, led to formation of a capsule flap through a normal foreign body reaction between 2 silastic sheet implants. On this induced capsule flap, a skin graft was performed and a total of 40 axial pattern capsulo-cutaneous flaps from 20 Sprague-Dawley rats were successfully obtained after nearly 12 weeks through 4 stages of experiment, including a delay procedure at the second stage. Pathology revealed neovascularization, and abundantly impregnated vascular structures near the pedicle were observed along with random pattern collagen fibers. The skin graft took 100% on this newlyformed axial pattern capsular flap and thus implied that the capsule structure was able to survive on it`s own and was able to support skin grafts. This new flap using only the isolated artery and vein structure can be induced according to various needs with minimal donor morbidity.
Arteries
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Collagen
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Femoral Artery
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Foreign-Body Reaction
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Free Tissue Flaps
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Humans
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Microsurgery
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Pathology
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Rats, Sprague-Dawley
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Skin
;
Tissue Donors
;
Tissue Transplantation
;
Transplants
;
Veins
7.Points to consider before the insertion of maxillary implants: the otolaryngologist's perspective
Sung Won KIM ; Il Hwan LEE ; Soo Whan KIM ; Do Hyun KIM
Journal of Periodontal & Implant Science 2019;49(6):346-354
Maxillary implants are inserted in the upward direction, meaning that they oppose gravity, and achieving stable support is difficult if the alveolar bone facing the maxillary sinus is thin. Correspondingly, several sinus-lifting procedures conducted with or without bone graft materials have been used to place implants in the posterior area of the maxilla. Even with these procedures available, it has been reported that in about 5% of cases, complications occurred after implantation, including acute and chronic sinusitis, penetration of the sinus by the implant, implant dislocation, oroantral fistula formation, infection, bone graft dislocation, foreign-body reaction, Schneiderian membrane perforation, and ostium plugging by a dislodged bone graft. This review summarizes common maxillary sinus pathologies related to implants and suggests an appropriate management plan for patients requiring dental implantation.
Dental Implantation
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Dental Implants
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Dislocations
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Foreign-Body Reaction
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Gravitation
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Humans
;
Maxilla
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Maxillary Sinus
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Maxillary Sinusitis
;
Nasal Mucosa
;
Oroantral Fistula
;
Pathology
;
Postoperative Complications
;
Sinusitis
;
Transplants