1.Life threatening and occult mediastinal haemorrhage secondary to acquired factor VIII deficiency.
Chieh Suai TAN ; Kenneth P CHAN ; Charles T CHUAH ; Heng Joo NG ; Foong Koon CHEAH ; Felicia S TEO ; Philip C T ENG
Annals of the Academy of Medicine, Singapore 2009;38(3):280-281
Aged
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Female
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Hemophilia A
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complications
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Hemorrhage
;
etiology
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Humans
;
Mediastinal Diseases
;
etiology
3.Pulmonary endarterectomy and balloon pulmonary angioplasty in chronic thromboembolic pulmonary hypertension: The Singapore experience.
Wen RUAN ; Jonathan YAP ; Kevin QUAH ; Foong Koon CHEAH ; Ghee Chee PHUA ; Duu Wen SEWA ; Aidila Binte ISMAIL ; Alicia CHIA ; David JENKINS ; Ju Le TAN ; Victor CHAO ; Soo Teik LIM
Annals of the Academy of Medicine, Singapore 2021;50(3):270-273
4.Clinical Updates on the Diagnosis and Management of Chronic Thromboembolic Pulmonary Hypertension.
Wen RUAN ; Jonathan Jl YAP ; Kevin Kh QUAH ; Foong Koon CHEAH ; Ghee Chee PHUA ; Duu Wen SEWA ; Aidila Binte ISMAIL ; Alicia Xf CHIA ; David JENKINS ; Ju Le TAN ; Victor Tt CHAO ; Soo Teik LIM
Annals of the Academy of Medicine, Singapore 2020;49(5):320-330
INTRODUCTION:
Chronic thromboembolic pulmonary hypertension (CTEPH) is a known sequela after acute pulmonary embolism (PE). It is a debilitating disease, and potentially fatal if left untreated. This review provides a clinically relevant overview of the disease and discusses the usefulness and limitations of the various investigational and treatment options.
METHODS:
A PubMed search on articles relevant to PE, pulmonary hypertension, CTEPH, pulmonary endarterectomy, and balloon pulmonary angioplasty were performed. A total of 68 articles were found to be relevant and were reviewed.
RESULTS:
CTEPH occurs as a result of non-resolution of thrombotic material, with subsequent fibrosis and scarring of the pulmonary arteries. Risk factors have been identified, but the underlying mechanisms have yet to be fully elucidated. The cardinal symptom of CTEPH is dyspnoea on exertion, but the diagnosis is often challenging due to lack of awareness. The ventilation/perfusion scan is recommended for screening for CTEPH, with other modalities (eg. dual energy computed tomography pulmonary angiography) also being utilised in expert centres. Conventional pulmonary angiography with right heart catheterisation is important in the final diagnosis of CTEPH.
CONCLUSION
Operability assessment by a multidisciplinary team is crucial for the management of CTEPH, as pulmonary endarterectomy (PEA) remains the guideline recommended treatment and has the best chance of cure. For inoperable patients or those with residual disease post-PEA, medical therapy or balloon pulmonary angioplasty are potential treatment options.
5.A practical and adaptive approach to lung cancer screening: a review of international evidence and position on CT lung cancer screening in the Singaporean population by the College of Radiologists Singapore.
Charlene Jin Yee LIEW ; Lester Chee Hao LEONG ; Lynette Li San TEO ; Ching Ching ONG ; Foong Koon CHEAH ; Wei Ping THAM ; Haja Mohamed Mohideen SALAHUDEEN ; Chau Hung LEE ; Gregory Jon Leng KAW ; Augustine Kim Huat TEE ; Ian Yu Yan TSOU ; Kiang Hiong TAY ; Raymond QUAH ; Bien Peng TAN ; Hong CHOU ; Daniel TAN ; Angeline Choo Choo POH ; Andrew Gee Seng TAN
Singapore medical journal 2019;60(11):554-559
Lung cancer is the leading cause of cancer-related death around the world, being the top cause of cancer-related deaths among men and the second most common cause of cancer-related deaths among women in Singapore. Currently, no screening programme for lung cancer exists in Singapore. Since there is mounting evidence indicating a different epidemiology of lung cancer in Asian countries, including Singapore, compared to the rest of the world, a unique and adaptive approach must be taken for a screening programme to be successful at reducing mortality while maintaining cost-effectiveness and a favourable risk-benefit ratio. This review article promotes the use of low-dose computed tomography of the chest and explores the radiological challenges and future directions.