Verruciform xanthoma is a rare benign lesion characterized by verrucous epidermal hyperplasia with aggregates of foam cells in dermal papillae. The pathogenesis is still unknown. Although most verruciform xanthoma tend to occur as isolated lesions, several have been associated with other conditions including squamous cell carcinoma and epidermal atypia. We describe a case of verruciform xanthoma associated with epidermal atypia.
Carcinoma, Squamous Cell ; Foam Cells ; Hyperplasia ; Xanthomatosis*

Foam Cells ; pathology ; Gastrointestinal Neoplasms ; pathology ; Humans

Recently, we have experienced two cases of xanthogranuloma in adults presenting either a solitary papule or multiple papules. Laboratory findings including blood lipid substances such as cholesterol and triglyceride were within normal limits. In both cases, we could not find any other extracutaneous manifestations. Granulomatous infiltrates containing foam cells, foreign body giant cells and Touton giant cells as well as histiocytes and lymphocytes were revealed by histopathologic findings.
Adult* ; Cholesterol ; Foam Cells ; Giant Cells ; Giant Cells, Foreign-Body ; Histiocytes ; Humans ; Lymphocytes ; Triglycerides

A 40-year old woman presented with a skin colored, multinodular, hard mass of 1.5x1.0cm and 1.0X1.0cm on the right 3rd toe for 20 years. Histopathologically, the tumor consisted of lobules of varied cellularity surrounded by dense collagen. Some areas were cellular and consisted of histiocyte-like cells, osteoclast-like giant cells, foam cells. Other areas were less cellular and consisted of spindle cells within hyalinized stroma, compatible with giant cell tumor of tendon sheath.
Adult ; Collagen ; Female ; Foam Cells ; Giant Cell Tumors* ; Giant Cells* ; Humans ; Hyalin ; Skin ; Tendons* ; Toes*

We herein report three caes of xanthogranuloma occurring in aduls representing solitary nodule or multiple papules. Blood lipid substances such as cholesterol and triglyceride were normal and extracutaneous manifestatioiis were not found in all cases. Histopathorogic findings commonly revealed a granulomatous infiltrate c(intaining foam cells, foreign body gianf. cells and Touton giant cells as well as histiocytes and lymphocytes.
Adult* ; Cholesterol ; Foam Cells ; Foreign Bodies ; Giant Cells ; Histiocytes ; Humans ; Lymphocytes ; Triglycerides

A 68-year-old woman presented with a solitary dome-shaped papule on the right forth finger and this lesion had been developing for the past 4 months. Histopathologic examination revealed the dermal infiltration of histiocytes with foam cells and Touton-type multinucleated giant cells, which was compatible with the diagnosis of xanthogranuloma. Based on the previous reports, xanthogranuloma of the finger is quite rare, and especially in adults. Herein, we report on a case of xanthogranuloma arising on the finger of an adult.
Adult ; Aged ; Female ; Fingers ; Foam Cells ; Giant Cells ; Hand ; Histiocytes ; Humans

Xanthogranulomatous pyelonephritis is a rare but chronic and severe infection of the kidney, characterized by extensive destruction of renal parenchyma and presence of granulomas, abscesses. foam cells, plasma cells and lymphocytes. Herein we present a case of xanthogranulomatous pyelonephritis, developed in 35 year-old woman with review of literatures.
Abscess ; Adult ; Female ; Foam Cells ; Granuloma ; Humans ; Kidney ; Lymphocytes ; Plasma Cells ; Pyelonephritis, Xanthogranulomatous*

Leukoplakia is a fixed, predominantly white-lesion of the mucosa. It is most often seen on the oral and anogenital mucosa. Leukoplakia should be biopsied to determine the true histopathologic diagnosis. Verruciform xanthoma is composed of asymptomatic, usually solitary, flat plaques or warty lesions. They may vary in color from gray to pink or yellow. Its pathogenesis is still unknown and usual site is the oral cavity. Histopathologically, it is characterized by verrucous epidermal hyperplasia with aggregates of foam cells in the dermal papillae. A review of literature indicated that verruciform xanthoma presenting as a whitish plaque on the lower lip was very rare. We describe a 70-year-old woman with verruciform xanthoma who presented with a whitish plaque on her lower lip.
Aged ; Diagnosis ; Female ; Foam Cells ; Humans ; Hyperplasia ; Leukoplakia* ; Lip* ; Mouth ; Mucous Membrane ; Xanthomatosis*

Focal segmental glomerulosclerosis (FSGS) is the name of the primary glomerular disease as well as the terminology to describe the secondary phenomena of any other glomerular diseases. It is characterized by sclerosis, hyalinosis, foam cell infiltration, vacuolar change of podocytes, and halo formation in the glomerulus. Throughout the interstitium, lymphocytes infiltration, tubular atrophy and vascular changes are accompanied. Occasionally, IgM and/or C3 depositions are noted in the sclerotic areas. Electron microscopically, diffuse effacement of foot processes are seen in non-sclerotic area like minimal change disease. Podocyte injury patterns including vacuolar changes are frequently examined. Recently, Columbia group has suggested morphologic classification of FSGS and they demonstrated very good prognosis of tip lesion and poor prognosis of both collapsing and cellular types. However, the pathogenetic classification has been suggested by others; hyperfilteration, podocyte injury, genetic lesions etc. Further studies are necessary to understand and treat this disease.
Atrophy ; Electrons ; Foam Cells ; Foot ; Glomerulosclerosis, Focal Segmental ; Immunoglobulin M ; Lymphocytes ; Nephrosis, Lipoid ; Podocytes ; Prognosis ; Sclerosis

A 72-year-old woman with a pea sized, bluish, firm nodule was diagnosed as having a cellular type of dermatofibroma histopathologically. A biopsy specimen revealed a relatively well circumscribed, non-encapsulated, nodular infiltration of irregularly distributed histiocytes in the deep dermis. Foam cells were also noted. Gomoris iron stain revealed large amounts of hemosiderin deposits and some collagen were present as individual fibers in the lesion with Masson's trichrome stain.
Aged ; Biopsy ; Collagen ; Dermis ; Female ; Foam Cells ; Hemosiderin ; Histiocytes ; Histiocytoma, Benign Fibrous* ; Humans ; Iron ; Peas