Verruciform xanthoma is a rare benign lesion characterized by verrucous epidermal hyperplasia with aggregates of foam cells in dermal papillae. The pathogenesis is still unknown. Although most verruciform xanthoma tend to occur as isolated lesions, several have been associated with other conditions including squamous cell carcinoma and epidermal atypia. We describe a case of verruciform xanthoma associated with epidermal atypia.
Carcinoma, Squamous Cell ; Foam Cells ; Hyperplasia ; Xanthomatosis*

Foam Cells ; pathology ; Gastrointestinal Neoplasms ; pathology ; Humans

Recently, we have experienced two cases of xanthogranuloma in adults presenting either a solitary papule or multiple papules. Laboratory findings including blood lipid substances such as cholesterol and triglyceride were within normal limits. In both cases, we could not find any other extracutaneous manifestations. Granulomatous infiltrates containing foam cells, foreign body giant cells and Touton giant cells as well as histiocytes and lymphocytes were revealed by histopathologic findings.
Adult* ; Cholesterol ; Foam Cells ; Giant Cells ; Giant Cells, Foreign-Body ; Histiocytes ; Humans ; Lymphocytes ; Triglycerides

A 40-year old woman presented with a skin colored, multinodular, hard mass of 1.5x1.0cm and 1.0X1.0cm on the right 3rd toe for 20 years. Histopathologically, the tumor consisted of lobules of varied cellularity surrounded by dense collagen. Some areas were cellular and consisted of histiocyte-like cells, osteoclast-like giant cells, foam cells. Other areas were less cellular and consisted of spindle cells within hyalinized stroma, compatible with giant cell tumor of tendon sheath.
Adult ; Collagen ; Female ; Foam Cells ; Giant Cell Tumors* ; Giant Cells* ; Humans ; Hyalin ; Skin ; Tendons* ; Toes*

A 68-year-old woman presented with a solitary dome-shaped papule on the right forth finger and this lesion had been developing for the past 4 months. Histopathologic examination revealed the dermal infiltration of histiocytes with foam cells and Touton-type multinucleated giant cells, which was compatible with the diagnosis of xanthogranuloma. Based on the previous reports, xanthogranuloma of the finger is quite rare, and especially in adults. Herein, we report on a case of xanthogranuloma arising on the finger of an adult.
Adult ; Aged ; Female ; Fingers ; Foam Cells ; Giant Cells ; Hand ; Histiocytes ; Humans

We herein report three caes of xanthogranuloma occurring in aduls representing solitary nodule or multiple papules. Blood lipid substances such as cholesterol and triglyceride were normal and extracutaneous manifestatioiis were not found in all cases. Histopathorogic findings commonly revealed a granulomatous infiltrate c(intaining foam cells, foreign body gianf. cells and Touton giant cells as well as histiocytes and lymphocytes.
Adult* ; Cholesterol ; Foam Cells ; Foreign Bodies ; Giant Cells ; Histiocytes ; Humans ; Lymphocytes ; Triglycerides

Xanthogranulomatous pyelonephritis is a rare but chronic and severe infection of the kidney, characterized by extensive destruction of renal parenchyma and presence of granulomas, abscesses. foam cells, plasma cells and lymphocytes. Herein we present a case of xanthogranulomatous pyelonephritis, developed in 35 year-old woman with review of literatures.
Abscess ; Adult ; Female ; Foam Cells ; Granuloma ; Humans ; Kidney ; Lymphocytes ; Plasma Cells ; Pyelonephritis, Xanthogranulomatous*

Leukoplakia is a fixed, predominantly white-lesion of the mucosa. It is most often seen on the oral and anogenital mucosa. Leukoplakia should be biopsied to determine the true histopathologic diagnosis. Verruciform xanthoma is composed of asymptomatic, usually solitary, flat plaques or warty lesions. They may vary in color from gray to pink or yellow. Its pathogenesis is still unknown and usual site is the oral cavity. Histopathologically, it is characterized by verrucous epidermal hyperplasia with aggregates of foam cells in the dermal papillae. A review of literature indicated that verruciform xanthoma presenting as a whitish plaque on the lower lip was very rare. We describe a 70-year-old woman with verruciform xanthoma who presented with a whitish plaque on her lower lip.
Aged ; Diagnosis ; Female ; Foam Cells ; Humans ; Hyperplasia ; Leukoplakia* ; Lip* ; Mouth ; Mucous Membrane ; Xanthomatosis*

We experienced a case of 16-year-old female with verruciform xanthoma transformed from lesions of epidermal nevus syndrome. The biopsy specimen of yellowish brown to red verrucous papule on the right buttock showed 1) uniform and verrucous acanthosis without cytological atypia, 2) parakeratosis and hyperkeratosis,3) variable foci of superficial necrosis with crusting and microabscess in the granular layer, 4) rete ridge elongation and papillomatosis, 5) characteristic foam cells located within the papillary dermis, but not below the rete ridges. Our case was diagnosed verruciform xanthoma by histopathologic finding which occured as a secondary development in lesions of epidermal nevus syndrome.
Adolescent ; Biopsy ; Buttocks ; Dermis ; Female ; Foam Cells ; Humans ; Necrosis ; Nevus ; Papilloma ; Parakeratosis ; Xanthomatosis*

Verruciform xanthoma (VX) is a rare, benign lesion that presents in the oral cavity, skin, or genital organs as a verrucous, papillomatous, or flat papule with varying colors. VX has indistinct clinical features, making histopathological examination necessary for a definitive diagnosis. Histologically, VX is characterized by parakeratosis, rete ridges with uniform depth, and an accumulation of the foam cells, which are also known as the "xanthoma cells". These foam cells test positive for antibodies, such as CD-68 and vimentin; it is thought that VX foam cells are derived from the monocyte-macrophage lineage, and that VX's pathogenic mechanism is partly related to an immune mechanism. Nevertheless, the pathogenesis of VX remains unclear. VX can be treated by surgical excision; other medical, chemical, and radiological treatments are not required postoperatively. Recurrence and malignant transformation of VX are rare. Two patients, each with a mass of unknown origin on the palatal gingiva, were presented at our clinic. Excisional biopsies of the masses were performed for a histological diagnosis after clinical and radiological examinations. Histological examination confirmed a diagnosis of VX in both cases.
Antibodies ; Biopsy ; Diagnosis ; Foam Cells ; Genitalia ; Gingiva* ; Humans ; Mouth ; Parakeratosis ; Recurrence ; Skin ; Vimentin ; Xanthomatosis*