No abstract available.
Dinoprost* ; Flurbiprofen* ; Gabexate* ; Prednisolone* ; Thromboxane B2*

We studied the effect of Ocufen(R), a new ophthalmic nonsteroidal antiinflammatory agent(Flubiprofen), on reducing pupillary constiction during cataract surgery. The study was performed on 63 patients(experimental group:43 patients control group:20 patients). Pupil diameters were meagured at the beginning, after anterior capsulotonly, after lens cortex extraction and after IOL insertion. Pre-operative pupillary diameters were not statisitically different between the control and experimental groups. The change of the pupillary deiameter from the beginning to after IOL insertion averaged 1.0mm in experimental group and 1.9mm in control group. The difference between two groups was statistically significant(P<0.01). The experimental group maintained pupillary dilation better on the average and much smaller incidence of pupil constriction greater than 2mm.
Cataract* ; Constriction ; Flurbiprofen ; Humans ; Incidence ; Ophthalmic Solutions* ; Pupil

We studied the effect of Ocufen(R), a new ophthalmic nonsteroidal antiinflammatory agent(Flubiprofen), on reducing pupillary constiction during cataract surgery. The study was performed on 63 patients(experimental group:43 patients control group:20 patients). Pupil diameters were meagured at the beginning, after anterior capsulotonly, after lens cortex extraction and after IOL insertion. Pre-operative pupillary diameters were not statisitically different between the control and experimental groups. The change of the pupillary deiameter from the beginning to after IOL insertion averaged 1.0mm in experimental group and 1.9mm in control group. The difference between two groups was statistically significant(P<0.01). The experimental group maintained pupillary dilation better on the average and much smaller incidence of pupil constriction greater than 2mm.
Cataract* ; Constriction ; Flurbiprofen ; Humans ; Incidence ; Ophthalmic Solutions* ; Pupil

We wanted to evaluate the effects of topical nonsteroidal antiinflammatory drugs (NSAIDs) on refractive outcome and corneal haze after PRK(photorefractive keratectomy) according to the degree of myopia, and compare their effect with those of topical steroids. We divided our patients into moderate myopes (< OR = -6.0D) and high myopes (> OR = -6.0D), and each patient was randomly allocated to one of three drugs for initial management: 0.1% fluorometholone, 0.03% flurbiprofen, 0.1% diclofenac for 4 months after PRK. In moderate myopes, steroid group and NSAIDs group showed no difference in refraction after 6 months, and the subjective haze grading was consistently lower in steroid group after 3 weeks. In high myopes, steroid group and NSAIDs group showed no difference in both refraction and corneal haze after 6 months. Steroid group showed severe myopic regression or corneal haze less frequently than NSAID groups in high myopes. Topical NSAIDs are assumed to be less effective than topical steroids in reducing myopic regression and haze especially in high myopes after PRK.
Anti-Inflammatory Agents, Non-Steroidal ; Diclofenac ; Fluorometholone ; Flurbiprofen ; Humans ; Lasers, Excimer* ; Myopia ; Photorefractive Keratectomy* ; Steroids

To evaluate the effect of topical corticosteroid and nonsteroidal antiinflammatory agents on corneal stromal wound healing after excimer laser keratectomy, each eye of 75 rabbit was ablated by excimer laser and the animals were divided into five groups (15 rabbits in each group). That is, group I of 0.1% dexamethasone, group II of 0.1 % fluorometholone, group III of 0.03 % flurbiprofen, group IV of 0.1 % dexamethasone and 0.03 % flurbiprofen and control group of balanced salt solution. All treatment regiments were instilled four times daily after keratectomy. The animals of each group were killed at 1 week, 1month and 3months after surgery to examine the thickness of newly formed collagen, the keratocyte density and the fine structural alteration in keratocytes and stroma. The results were as follows; 1. The thickness of the new stroma was maximum in control group and minimum in group IV, and significantly different not only between the control and each experimental group but also between experimental groups except between group I and IV (p<0.05). 2. The keratocyte count was maximum in control group and minimum in group IV and the difference was significant between the control group and each experimental groups, but among experimental groups there was significant difference between I and III and between III and IV only. 3. Under transmission electron microscope at 12 weeks, the keratocyte activity and microscopic structural change were markedly subsided in each experimental group but sustainod in control. Basod on these observations, the topically applied steroid and nonsteroidal antiinflammatory drug can modulate the stromal wound healing process after excimer laser keratectomy and the effect, which can be evaluated by the quantitative analysis of the morphologic changes, is the most prominent in Dexamethasone treated group.
Animals ; Anti-Inflammatory Agents, Non-Steroidal* ; Collagen ; Dexamethasone ; Fluorometholone ; Flurbiprofen ; Lasers, Excimer* ; Rabbits* ; Steroids* ; Wound Healing

The purpose of this study was to evaluate the effects of tetracycline(TC), flurbiprofen, and PDGF-BB loaded biodegradable membranes on the cell-attachment, the activity of loaded PDGF-BB, in vivo release kinetics, and guided bone regenerative potentials. To evaluate the cell attachment to membranes, the number of gingival fibroblasts attached to each membrane(10% TC, 10% flurbiprofen, 200ng/cm2 PDGF-BB loaded membranes, drug-unloaded membrane) was counted by coulter counter and the morphologic pattern of attached cells was examined under SEM. To determine whether the activity of loaded PDGF-BB is sustained, the cellular growth and survival rate of gingival fibroblasts was used for both standard PDGF-BB and loaded PDGF-BB. For evaluation of in vivo release kinetics, drug-loaded membranes were implanted on the dorsal skin of the rats. On 1, 3, 7, 10, 14, 21, and 28 days after implantation, the amount of remaining drugs were measured by HPLC assay for TC and flurbiprofen, and by gamma-scintillation counter for PDGF-BB(I125). For evaluation of guided regenerative potential, the amount of new bone in the calvarial defects(5mm in diameter) of the rat was measured by histomorphometry 1 and 2 weeks after implantation of membranes. The number of cells attached to the PDGF-BB loaded membrane was largest as compared with the other membranes.(p<0.05) The activity of loaded PDGF-BB was not significantly different from the activity of standard PDGF-BB.(p< 0.05) After initial burst release of drug during the first 24 hours, drugs were gradually released for 4 weeks. Especially the release rate of PDGF-BB was nearly constant during 4 weeks. PDGF-BB loaded membranes(200, 400ng/cm2) were effective in guided bone regeneration as compared with drug-unloaded membrane. These results implicate that drug-loaded biodegradable membranes might be a useful for guided bone regeneration.
Animals ; Bone Regeneration ; Chromatography, High Pressure Liquid ; Fibroblasts ; Flurbiprofen ; Kinetics ; Membranes* ; Rats ; Skin ; Survival Rate ; Tetracycline

BACKGROUNDSystemic non-steroidal anti-inflammatory drugs have been evaluated for their possible preemptive analgesic effects. The efficacy of flurbiprofen axetil for preemptive analgesia in patients undergoing radical resection of esophageal carcinoma via the left thoracic approach needs further investigation. The aim of this study was to research the preemptive analgesic effects of flurbiprofen axetil in thoracic surgery, and the influence of preoperative administration on postoperative respiratory function.

METHODSThis randomized, double-blind, controlled trial enrolled 60 patients undergoing radical resection of esophageal carcinoma via the left thoracic approach. Anesthesia management was standardized. Each patient was randomly assigned to receive either 100 mg flurbiprofen axetil intravenously 15 minutes before incision (PA group) or intravenous normal saline as a control (C group). Postoperative analgesia was with sufentanil delivered by patient-controlled analgesia pump. Postoperative sufentanil consumption, visual analog scale pain scores, plasma levels of interleukin-8, and oxygenation index were measured.

RESULTSCompared with the preoperative baseline, postoperative patients in the PA group had no obvious increase in pain scores (P > 0.05), but patients in the C group had significantly increased pain scores (P < 0.05). Pain scores in the C group were significantly higher at 24 hours postoperatively than preoperatively. Intergroup comparisons showed lower visual analog scale scores at 2 - 24 hours postoperatively in the PA group than the C group (P < 0.05). Sufentanil consumption and plasma interleukin-8 levels at 2 and 12 hours postoperatively were significantly lower in the PA group than the C group (P < 0.05). The oxygenation index at 2 and 12 hours postoperatively was significantly higher in the PA group than the C group (P < 0.05).

CONCLUSIONSIntravenous flurbiprofen axetil appears to have a preemptive analgesic effect in patients undergoing radical resection of esophageal carcinoma via the left thoracic approach, and appears to contribute to recovery of respiratory function and to reduction of the postoperative inflammatory reaction.

Animals ; Brain Ischemia ; drug therapy ; Cyclooxygenase Inhibitors ; pharmacology ; Flurbiprofen ; analogs & derivatives ; Male ; Neuroprotective Agents ; pharmacology ; PPAR gamma ; physiology

Analgesia ; methods ; Cholecystectomy, Laparoscopic ; methods ; Female ; Flurbiprofen ; analogs & derivatives ; pharmacology ; Humans ; Isoxazoles ; pharmacology ; Male ; Platelet Aggregation ; drug effects

Objective To observe the changes of brain function in patients with trigeminal neuralgia after administration of flurbiprofen axetil by using the resting-state functional magnetic resonance imaging(fMRI)and based on the amplitude of low-frequency fluctuation(ALFF). Methods Resting fMRI data of 20 patients with trigeminal neuralgia before and after treatment with flurbiprofen axetil were collected by 1.5T magnetic resonance imaging system.The resting fMRI data were pretreated by Statistical Parametric Mapping and DPABI(a toolbox for Data Processing and Analysis for Brain Imaging)software,and the difference of low-frequency oscillation amplitude of brain spontaneous activity before and after treatment with flurbiprofen axetil was analyzed by ALFF. Results The Visual Analogue Scale of pain intensity after flurbiprofen axetil injection was significantly lower than that before administration,and the pain relieved significantly(P=0.000).The ALFF values of right dorsolateral prefrontal lobe,bilateral medial prefrontal lobe,and right middle cingulate gyrus in patients treated with flurbiprofen axetil at rest were significantly lower than those before administration(P=0.000). Conclusions The analgesic effect of flurbiprofen axetil is exerted on the central system.This agent can inhibit the abnormal brain function caused by chronic pain stimulation and thus reduce pain.However,the specific mechanism needs further investigations.
Brain ; drug effects ; Brain Mapping ; Flurbiprofen ; analogs & derivatives ; pharmacology ; Humans ; Magnetic Resonance Imaging ; Trigeminal Neuralgia ; drug therapy