Carried on the exploration testing of flow rate of infusion device about industry standard YY 0451-2010. Engaged in flow rate experiments adopting different method that are provided by new and old industry standard for samples of the same type. Compared with the result of the dangerous coefficient by calculating the test data, the old standard can be more sensitive to reflect the situation of product flow rate, so it can be applied to conventional control of the products. The method which provided by the new industry standard is suitable for evaluating periodicity the level of product contaminated.
Flowmeters ; Infusion Pumps

The ability of nicotinic acid and its substitutes to increase cutaneous blood flow has been measured by laser Doppler flowmeter in 30 healthy human volunteers. We applied nicotinarnide, nicotinic acid ethyl ester, nicotinic acid methyl ester, hexyl nicozinate each in an acqeous solution at a concentration of 10 mM/liter for 10 minutes occlusion on the forearm. The change of blood flow was serially checked at 5 to 10 minutes intervals for one hour. The study results were as follows : l. The relative maximum cutaneous blood flow response was in following order nicotinic acid methyl ester(100%), nicotinic acid ethyl ester(98%), hexyl nicotinate (84%) and nicotinic acid(63%). However, there was no statistically significant difference(p>0.05) between each drug. There was statististically significant difference between nicotinamide and all other nicotinic acid substitutes(p<0.05). 2. The time required to reach maximum blood flow response was 6.7 minutes for hexyl nicotinste, 10 minutes for nicotinic acid ethyl ester, 12.5 minutes for nicotinic acid methyl ester and 20 minutes for nicotinic acid. However, there was statistically significant difference between hexyl nicotinate and nicotinic acid only(p<0.05). 3. Significant decrease of cutaneous blood flow was observed one hour after the removal of the patches in all drugs.
Flowmeters ; Forearm ; Healthy Volunteers ; Niacin* ; Niacinamide

The objective of this study was to evaluated the ariability of measurements of the optic nerve head(ONH) and peripapillary retinal blood flow using Heidelberg Retina flowmeter. Ten eyes of 10 ocularly normal subjects underwent scanning laser Doppler flowmetry. Each eye was scanned in 2 sessions which were separated by 30 minutes. In each session, 5 scans centerd on the ONH using a 10*2.5 degree scan angle were obtained. We identified 10 locations(4 locations in the cup of ONH) and took measurements at the same locations in all scans. The coefficient of variation(CVs, %) for volume, flow, and velocity ranged from 8.1 to 13.0%, 9.9 to 16.0%, and 9.9 to 14.6%, respectively. The CVs of measurements in the neural rim, peripapillary retina, and cup ranged from 9.1to 15.9%, 8.1 to 10.7%, and 11.8 to 16.0%, respectively. The Pearson's coefficients of correlation (r) showed significant correlation in the all parameters in the peripapillary retina and in the flow and velocity in the neural rim. In conclusion, scanning laser Doppler flowmetry provides reproducible measurement of ONH and retinal blood flow.
Flowmeters ; Laser-Doppler Flowmetry* ; Optic Disk* ; Optic Nerve* ; Retina ; Retinaldehyde*

Compromise of the tissue circulation plays a significant role in the development of optic nerve damage in normal-tension glaucoma (NTG). To evaluate the effect of nifedipine on the blood flow of peripapillary retina, blood flow of 7 NTG patients were measured using Heidelberg Retina Flowmeter before and 1 hour after oral administration of nifedipine 5 mg.Before treatment, NTG eyes had significantly reduced blood flow than control eyes (245.99+/-132.91 vs.303.38 +/-121.07, p=0.036).After treatment, nifedipine increased blood flow (245.99 +/-132.91 vs.329.37 +/-189.17, p=0.005)and decreased intercapillary square (49.78 +/-17.30 micrometer vs.47.13 +/-15.13 micrometer , p=0.049)significantly in the NTG eyes, but did not affect blood flow in the control eyes (303.38 +/-121.07 vs.309 +/-85.53, p=0.756).These results show that glaucomatous optic nerve damage is accompanied with blood flow deficits and nifedipine improve ocular hemodynamics in normal-tension glaucoma.
Administration, Oral ; Flowmeters ; Glaucoma ; Hemodynamics ; Humans ; Nifedipine* ; Optic Nerve ; Retina

No abstract available.
Animals ; Flowmeters* ; Magnets* ; Male ; Models, Animal* ; Penile Erection* ; Rats*

BACKGROUND: Portable devices for measuring peak expiratory flow(PEF) are now of proved value in the diagnosis and management of asthma and many lightweight PEF meters have become available. However, it is necessary to determine whether peak expiratory flow rate(PEFR) measurements measured with peak flowmeters is accurate and reproducible for clinical application. The aim of the present study is to define accuracy, agreement, and precision of mini-Wright peak flow meter(MPFM) against standard pneumotachygraph. METHODS: The lung function tests by standard pneumotachygraph and PEFR measurement by MPFM were performed in a random order for 2 hours in 22 normal and 17 asthmatic subjects and also were performed for 3 successive days in 22 normals. RESULTS: The PEFR measured with MPFM was significantly related to the PEFR and FEV1 measured with standard pneumotachygraph in normal and asthmatics(for PEFR, r=0.92 p<0.001; for FEV1, r=0.78 ; p<0.001). The accuracy of MPFM was within 10%(limits of accuracy recommeded by NAEP) in all the subjects or 22 normal, mean difference from standard pneumotachygraph being I 6.5L/min(percentage of difference being 2.90%) or 1 0.6L/min(percentage of difference being 1.75%), respectively. According to the method proposed by Bland and Altman, the 95% limits of the distribution of differences between MPFM and standard pneumotachygraph after correction of PEFR using our regression equation were +38.2 and -71.5L/min in all the subjects or -20.49~ + 9.49L/min in 22 normal and was similar to the intraindividual agreements for 3 successive days in normal. There was no statistically significant difference of PEFR measured with MPFM and standard pneumotachygraph among three days(p>0.05) and the coefficient of variation(2.4 1.2%) of PEFR measured with MPFM was significantly lower than that( 5.2 3.5%) with standard pneurnotachygraph in normal (p<0.05). CONCLUSION: This results suggest that the MPFM was as accurate and reproducible as standard pneumotachygraph for monitoring of PEFR in the asthmatic subjects.
Asthma ; Diagnosis ; Flowmeters ; Peak Expiratory Flow Rate ; Respiratory Function Tests

BACKGROUNG AND OBJECTIVES: The aim of this study was to analyze the influence of changes in ventricular preload and afterload, atrial and ventricular pacing on the coronary flow reserve (CFR). METHOD: Five open chest anesthetized dogs were studied in five sequential stages:baseline, saline solution volume loading (293.8+/-29.2 ml for 10 min), atrial and ventricular pacing (120, 140, and 160 bpm), and aortic clamp. Coronary blood flow (CBF) was measured with electro-magnetic flowmeter. CFR was defined as the ratio of hyperemic CBF (hCBF) to resting CBF (rCBF). Hyperemia was induced by IV adenosine infusion (1 mg/kg/min). RESULTS: 1)After volume loading wtih saline solution, CFR significantly decreased (p<0.05) because rCBF was increased while hCBF remained unchanged. 2)Atrial pacing produced increase in rCBF but did not change hCBF. Consequently CFR singificantly reduced when heart rate (HR) increased from sinus rhythm to 120, 140, and 160 bpm (p<0.01). 3)Ventricular pacing produced decrease in hCBF but did not change rCBF. Consequently CFR significantly reduced as HR increased from sinus rhythm to 120 (p<0.05) , 140 (p<0.01), and 160 (p<0.01) bpm. 4)After aortic clamp, CFR significantly decreased (p<0.01) because rCBF increased while hCBF remained unchanged. CONCLUSION: We found that CFR is dependent on the changes in volume loading, HR, and ventricular afterload that may commonly occur in clinical situations.
Adenosine ; Animals ; Dogs* ; Flowmeters ; Heart Rate ; Hyperemia ; Sodium Chloride ; Thorax

PURPOSE: This survey was intended to investigate the awareness and application of the asthma guideline among pediatricians. Insight into the feasibility in the guidelines can guide implementation strategies in the future and, if necessary, support the revision of the previous guideline. METHODS: This self-administered survey study was conducted with the data on 10 items of questionnaire about knowledge and implementation of Korean childhood asthma guideline. The data was analyzed using SPSS WINDOW 8.0. RESULTS: A total of 141 doctors out of 500 participants in the pediatric refresh course responded the questionnaire. Ninety-five percent of the responders were aware of guideline, but differences were found between the asthma management policies in the guideline and their habitual practice patterns. As far as the prescription of inhaled corticosteroid, approximately half of the responders followed the guideline. For peak flowmeter use, 57% of the responders never prescribed peak flowmeter and only 5% of the responders used peak flowmeter frequently. The barriers pediatricians face when applying the guideline in the practice were habitual management pattern, time limitation, low compliance, lack of knowledge and economic burden. CONCLUSION: The guideline for diagnosis and management of childhood asthma seemed to be recognized widely, however, the role of the guideline to change pediatricians habitual practice was limited. These data clearly indicate a need for further educational programs directed to both physicians and patients. Finally the development of more practical evidence- based guideline is needed
Asthma* ; Compliance ; Diagnosis* ; Flowmeters ; Humans ; Prescriptions ; Surveys and Questionnaires

We investigated the effect of 2% dorzolamide and 0.12% UF-021 on intraocular pressure and peripapillary and optic nerve head microcirclation with Heidelberg Retina Flowmeter. The 40 eyes of 40 normal subjects were divided 2 groups. 2% Borzolamide and 0.12% UF-021 were instilled in each group. The IOP and microcirculation of peripillary retina and optic nerve head were measured before and 90min, 4, 8, 12, 24 hours after instillation. The IOP was decreased at 90 minutes, 4, 8 hours after instillation of 2% dorzolamide and maximal reduction of IOP was observed at 90 minutes (P<0.05). The IOP was decreased at 90min, 4, 8, 12 hours after instillation of 0.12% UF-021 and maximal reduction of IOP was observed at 4 hours(P<0.05). But, there was no statistically significant changes of microciculation in both groups(P>0.05). We suggest that 2% dorzolamide and 0.12% UF-021 reduce the IOP, but do not alter the mictocirculation of peripapillary retina and optic nerve head.
Flowmeters ; Intraocular Pressure* ; Microcirculation ; Optic Disk* ; Optic Nerve* ; Retina ; Retinaldehyde*

We investigated the acute effects of timolol (beta-adrenergic non-selective) and betaxolol (beta1-adrenergic selective) on the retinal and optic nerve head (ONH) microcirculation in healthy subjects with Heidelberg Retina Flowmeter (HRF). Intraocular pressure (IOP), heart rate, blood pressure, and retinal and ONH microcirculation were measured in 7 healthy subjects (3 F/ 4 M; mean age=27.2 +/- 1.1 years) before and 90 minutes after instillation of each drug on separate occasions at 2 weeks apart. Volume, flow, and velocity of microcirculation in the peripapillary retina and neural rim of ONH were measured using HRF. Both drugs significantly reduced IOP (Wilcoxon signed rank test; p=.03) without affecting heart rate or blood pressure. It had no effect on the volume, flow, and velocity of blood flow in the peripapillary retina and ONH (Wilcoxon signed rank test; p>.1), From the above results, we concluded that both timolol and betaxolol did not alter retinal and ONH microcirculation.
Betaxolol* ; Blood Pressure ; Flowmeters ; Heart Rate ; Intraocular Pressure ; Microcirculation ; Optic Disk* ; Optic Nerve* ; Retina ; Retinaldehyde* ; Timolol*