1.Chemical structure of capsicuoside A from fruits of Capsicum annuum.
Hui-Xin CHEN ; Chang-An GENG ; Tuan-Wu CAO ; Xue-Mei ZHANG ; Yun-Bao MA ; Xiao-Yan HUANG ; Ji-Jun CHEN
China Journal of Chinese Materia Medica 2013;38(12):1934-1937
Five compounds were isolated from Capsicum annuum by means of various chromatographic techniques (silica gel, Sephadex LH-20, MCI GEL CHP-20P and HPLC), and their structures were determined as luteolin-7-O-[2"-O-(5"-O-sinapoyl)-beta-D-apiofuranosyl]-beta-D-glucopyranoside (1), uridine (2), adenosine (3), 7-hydroxy-6-methoxy cinnamic acid ethyl ester (4) and 7-hydroxy cinnamic acid ethyl ester (5) by extensive spectroscopic analyses (UV, IR, MS, 1D- and 2D-NMR). Among them, compound 1 is a new flavone glycoside named as capsicuoside A, and cmpounds 2-5 are isolated for the first time from the fruits of C. annuum.
Capsicum
;
chemistry
;
Flavones
;
chemistry
;
Fruit
;
chemistry
;
Glucosides
;
chemistry
2.Synthesis and antioxidative activity of flavone derivatives containing 1,2,4-triazole structure.
Zhi-fang DUAN ; Ling SHAO ; Sai-nan LI
Acta Pharmaceutica Sinica 2015;50(7):861-867
Using bioactive compounds 7-hydroxy flavone, salicylaldehyde, cinnamic acid and 4-amino-5- mercapto-1,2,4-triazoles as starting materials, three new types of flavone derivatives containing 1,2,4-triazole structure were synthesized via different step reactions. These new compounds were characterized by 1IHNMR, ESI-MS, IR and elemental analysis. Their scavenging effects on the superoxide radical (O2·-), hydroxyl radical (·OH), DPPH · radical and their total reduction activities were tested. The results showed that all of the compounds possessed some antioxidative activity at the concentration of 0.5 mg · mL(-1), but the scavenging ability of the target compounds was lower than that of the standard compound Vc.
Cinnamates
;
chemistry
;
Flavones
;
chemical synthesis
;
chemistry
;
Flavonoids
;
chemistry
;
Free Radical Scavengers
;
chemical synthesis
;
chemistry
;
Triazoles
;
chemistry
3.Studies on chemical constituents in buds of Artemisia scoparia.
Qi-wei ZHANG ; Yong-xi ZHANG ; Ying ZHANG ; Yong-qing XIAO ; Zhi-min WANG
China Journal of Chinese Materia Medica 2002;27(3):202-204
OBJECTIVETo investigate the chemical constituents in flower buds of Artemisia scoparia.
METHODThe constituents were separated and purified by means of various chromatographic techniques, and their structures were determined on the basis of physical and chemical properties and spectral data.
RESULTFour flavones were isolated and their structures were identified as cirsilineol (I), cirsimaritin(II), arcapillin(III) and cirsiliol(IV) respectively.
CONCLUSIONCompounds I, III and IV were isolated from this plant for the first time.
Artemisia ; chemistry ; classification ; Flavones ; Flavonoids ; chemistry ; isolation & purification ; Flowers ; chemistry ; Plant Leaves ; chemistry ; Plants, Medicinal ; chemistry
4.Optimal extraction of nuciferine and flavone from lotus leaf based on central composite design and response surface methodology.
Guo-Hua WANG ; Bao-Xian ZHANG ; Qi-Xia NIE ; Hui LI ; Chen ZANG
China Journal of Chinese Materia Medica 2008;33(20):2332-2335
OBJECTIVETo optimize the process of extracting effective constituents from lotus leaf.
METHODIndependent variables were ethanol concentration reflux time and solvent fold, dependent variables were extraction rates of nuciferine and flavone in lotus leaf, central composite design and response surface methodology were used for optimization of extraction of lotus leaf.
RESULTThe optimum conditions of extraction process were 75% -80% ethanol, 2-3 hours for reflux, 20-25 fold solvent and 2 times for extraction. Bias between observed and predicted of rates of nuciferine and flavone values were 5.53%, -6.02%, respectively.
CONCLUSIONThe values observed and predicted were close to each other, which proved that the optimization of of extraction of lotus leaf by central composite design and response surface methodology was reasonable and successful.
Aporphines ; chemistry ; isolation & purification ; Flavones ; Flavonoids ; chemistry ; isolation & purification ; Loteae ; chemistry ; Plant Leaves ; chemistry ; Reproducibility of Results
5.Chemical constitutes of flavones from Pu-erh tea.
China Journal of Chinese Materia Medica 2013;38(10):1552-1555
The chemical constituents in the Pu-erh tea were isolated by various column chromatographic methods, and their structures were identified by spectral data and physic-chemical analysis. As a result, eleven flavonoids were isolated and identified as kaempferol (1), quercetin (2), kaempferol-3-O-beta-D-glucopyranoside (3), kaempferol-3-O-beta-D-rutinoside (4), apigenin-6-C-alpha-L-arabinopyranosyl-8-C-beta-D-glucopyranoside (5), vitexin-4"-O-beta-D-glucopyranoside (6), kaempferol-3-O-[alpha-L-rhamnopyranosyl-(1--> 3)-alpha-L-rhamnopyranosyl-(1-->6)-beta-D-glucopyranoside] (7), quercetin3-O-beta-D-glucopyranoside (8), rutin (9), quercetin-3-0-alpha-L-rhamnopyranoside (10), and myricetin-3-0-beta-D-glucopyranoside (11). Compounds 5-7, 10 and 11 were isolated from Pu-erh tea for the first time.
Camellia sinensis
;
chemistry
;
Flavones
;
chemistry
;
Mass Spectrometry
;
Molecular Structure
;
Plant Extracts
;
chemistry
;
Tea
;
chemistry
6.Two new flavones from Fordia cauliflora of Yunnan.
Zhi-Yuan LIANG ; Xiao-Sheng YANG ; Hai-Yan ZHU ; Xiao-Jiang HAO
Acta Pharmaceutica Sinica 2006;41(6):533-536
AIMTo study the chemical constituents of the stem of Fordia cauliflora of Yunnan province.
METHODSThe constituents were separated and purified by repeated silica column chromatography. The structures were elucidated by physical-chemical properties and spectroscopic data.
RESULTSSix compounds were isolated from the ethanol extract of the stem of Fordia cauliflora. They were identified as: 6-hydroxy-3-methoxy-6",6"-dimethylchromeno-(2", 3" : 7, 8)-flavone (1), 3-methoxy-6-(3-methyl-but-2-enyloxy)-6", 6"-dimethylchromeno-( 2", 3" : 7, 8)-flavone (2), 3, 6-dimethoxy-6", 6"-dimethylchromeno-( 2", 3" : 7, 8)-flavone (3), 7-hydroxy-4'-methoxyisoflavone (4), 7, 4'-dihydroxyisoflavone (5) and karanjin (6).
CONCLUSIONCompounds 1 and 2 are new compounds. Compounds 3 -5 were isolated from the plant for the first time.
Fabaceae ; chemistry ; Flavones ; chemistry ; isolation & purification ; Molecular Structure ; Plant Stems ; chemistry ; Plants, Medicinal ; chemistry
7.Advances in chemical components and pharmacology of genus Gentiana.
Caijun WANG ; Zhimin WANG ; Weihao WANG ; Xinjun PENG
China Journal of Chinese Materia Medica 2009;34(23):2987-2994
The recent progresses on chemical components and pharmacological activities of the genus Gentiana were summarized. The main chemical constituents of this genus are iridoids, xanthone and flavone. There were more than ninety iridoid compounds, one hundred xanthone compounds, and thirty four flavone compounds isolated up till now. And flavone compounds were obtained mainly from aerial part. The plants of this genus had broad bioactivities such as antifungal activity, anti-inflammatory activity and liver protective effect. These mentioned above would be helpful for further studies on the plants of the genus Gentiana.
Animals
;
Drugs, Chinese Herbal
;
chemistry
;
pharmacology
;
Flavones
;
Flavonoids
;
chemistry
;
pharmacology
;
Gentiana
;
chemistry
;
Humans
;
Xanthones
;
chemistry
;
pharmacology
8.Studies on chemical constituents in spikes of Schizonepeta tenuifolia.
Yuan-hu ZHANG ; Lan ZHOU ; Ren-bing SHI ; Ya-jian GUO ; Yu DONG
China Journal of Chinese Materia Medica 2006;31(15):1247-1249
OBJECTIVETo study the chemical constituents in the spikes of Schizonepeta tenuifolia.
METHODCompounds were isolated and purified with silica gel, ODS and Sephadex LH-20 gel column chromatography, and their structures were determined by using spectroscopic analysis including MS and NMR.
RESULTNine compounds were isolated and identified as 5, 7-dihydroxy-6, 4'-dimethoxyflavone (1), 5, 7-dihydroxy-6, 3', 4'-trimethoxyflavone (2), ursolic acid (3), 3-hydroxy-4(8)-ene-p-menthane-3(9)-lactone (4), 5, 7, 4'-trihydroxyflavone (5), 5, 4'-dihydroxy-7-methoxyflavone (6), hesperidin (7), luteolin (8) and daucesterol (9).
CONCLUSIONCompounds 1, 2, 6 were first obtained from the spikes of S. tenuifolia.
Flavones ; chemistry ; isolation & purification ; Flowering Tops ; chemistry ; Lamiaceae ; chemistry ; Plants, Medicinal ; chemistry
9.Studies on the flavonoids from whole herbs of Seriphidium terrae-albae.
China Journal of Chinese Materia Medica 2006;31(10):820-822
OBJECTIVETo investigate the chemical constituents of whole herbs of Seriphidium terrae-albae.
METHODVarious chromatographic techniques were employed for the isolation and purification of the chemical constituents. The structures were elucidated by chemical and spectral analysis.
RESULTSeven flavonoid compounds were isolated and identified as apigenin, eupatilin, chrysoeriol, quercetin-3, 3'-dimethyl ether, quercetagetin-3, 6-dimethyl ether, quercetagetin-3, 6-dimethyl ether-7-O-beta-D-pyranoglucoside and quercetagetin-3, 6-dimethyl ether-4'-O-beta-D-pyranoglucoside, respectively.
CONCLUSIONAll of these flavonoid compounds were isolated from the plant for the first time.
Apigenin ; chemistry ; isolation & purification ; Asteraceae ; chemistry ; Flavones ; Flavonoids ; chemistry ; isolation & purification ; Plants, Medicinal ; chemistry
10.Evaluation of AB-8 macroporous adsorption resin for adsorption of total flavones in liquorice.
Bo HAN ; Wen CHEN ; Wen-juan JIN ; Shao-peng LIU
Journal of Southern Medical University 2007;27(3):265-267
OBJECTIVETo evaluate the performance of AB-8 macroporous adsorption resin for adsorption and desorption of flavones in liquorice.
METHODSThe concentration of flavones in liquorice was determined by ultraviolet spectrophotometry, and the adsorption behavior of AB-8 macroporous adsorption resin to flavones in liquorice was examined for the adsorption capacity and the volume of solution loaded.
RESULTSOptimal adsorption of flavones was achieved with the sample pH of 5, total flavones concentration in the solution of 0.85 mg/ml, sample flow velocity of 3 BV/h, and washing with 60% ethanol at the flow velocity of 3 BV/h.
CONCLUSIONAB-8 macroporous adsorption resin can be well applicable for enrichment of flavones in liquorice.
Adsorption ; Flavones ; chemistry ; isolation & purification ; Glycyrrhiza ; chemistry ; Macromolecular Substances ; chemistry ; Porosity ; Resins, Synthetic ; chemistry ; Spectrophotometry, Ultraviolet