1.Single nucleotide polymorphisms, inflammation and nutrition of genes.
Acta Academiae Medicinae Sinicae 2005;27(6):790-792
Inflammation is part of the immune response, and inflammation may also induce or exaggerate some diseases through production of pro-inflammatory cytokines. More evidence have shown that the individual level of cytokine production is affected by single nucleotide polymorphisms in cytokine genes. Furthermore, as several nutrients participate in DNA protection and stabilization, altering gene expression and individual phenotype, nutrition has important interaction with inflammation. The purpose of this review is to give a recent update informations on the interaction of single nucleotide polymorphisms, inflammation and nutrition.
Fatty Acids
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pharmacology
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Fish Oils
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pharmacology
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Humans
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Inflammation
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genetics
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therapy
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Nutrition Therapy
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Polymorphism, Single Nucleotide
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drug effects
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Vitamins
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pharmacology
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Zinc
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pharmacology
2.Correlation between the eicosapentaenoic acid, docosahexaenoic acid and the aggressive behavior in mice.
Journal of Forensic Medicine 2011;27(2):120-124
OBJECTIVE:
To explore the correlation between the eicosapentaenoic acid(EPA), docosahexaenoic acid (DHA) and the aggressive behavior in mice.
METHODS:
Seventy-two male Kunming mice were divided into control group, fish oil group, simvastatin group and aggressive reference group randomly. The control group, fish oil group and simvastatin group were given normal saline, fish oil and simvastatin by irrigation respectively for 3 months consecutively, each mouse was raised isolatedly. The latent period of assault, the frequencies of tail swing and assault, and the cumulative time of assault were recorded at the beginning and the end of the intervention. Finally, the EPA and DHA in brain were analyzed by gas chromatography-mass spectrometry (GC-MS). The aggressive reference group was raised without intervention and was evaluated as aggressive reference only.
RESULTS:
(1) Before intervention, the latent period of assault, the frequencies of tail swing, the frequencies of assault, and the cumulative time of assault were not significantly different from each other group. After intervention, the differences were significant (P<0.05). (2) After the intervention, the content of EPA and DHA in mice brain was the most in the fish oil group, and the least in the simvastatin group. (3) The content of EPA was negatively related with the four indexes (P<0.05) before and after the intervention. The content of DHA was negatively related with the frequencies of tail swing and assault (P<0.05).
CONCLUSION
There is a correlation between the EPA, DHA and aggressive behavior in mice under stress.
Aggression/physiology*
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Animals
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Behavior, Animal/physiology*
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Brain/metabolism*
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Docosahexaenoic Acids/metabolism*
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Eicosapentaenoic Acid/metabolism*
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Fatty Acids, Omega-3/metabolism*
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Fish Oils/pharmacology*
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Gas Chromatography-Mass Spectrometry
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Male
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Mice
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Random Allocation
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Simvastatin/pharmacology*
3.Protective effects of omega-3 fish oil on lead-induced impairment of long-term potentiation in rat dentate gyrus in vivo.
Xiu-Jing CAO ; Jie-Jie CAO ; Ting-Ting CHEN ; Wei-Heng CHEN ; Di-Yun RUAN
Acta Physiologica Sinica 2010;62(3):225-230
In order to evaluate the effect of omega-3 fish oil supplement by gavage (0.4 mL/100 g body weight) on the chronic lead-induced (0.2% lead acetate) impairments of long-term potentiation (LTP) in rat dentate gyrus (DG) in vivo, we designed the experiments which were carried out in four groups of newborn Wistar rats (the control, the lead-exposed, the control with fish oil treatment and the lead-exposed with fish oil treatment, respectively). The excitatory postsynaptic potential (EPSP) and population spike (PS) amplitude were measured in the DG of rats with above different treatments at the age of 80-90 d in response to stimulation applied to the lateral perforant path. The results showed (1) postnatal chronic lead-exposure impaired LTP measured on both EPSP slope and PS amplitude in DG area of the hippocampus; (2) in the control rats, omega-3 fish oil had no effect on LTP while in the lead-exposed rats, omega-3 fish oil had a protective effect on LTP. These results suggest that omega-3 fish oil supplement could protect rats from the lead-induced impairment of LTP. Omega-3 fish oil might be a preventive substance in reducing LTP deficits induced by lead.
Animals
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Animals, Newborn
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Dentate Gyrus
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drug effects
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Excitatory Postsynaptic Potentials
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Fatty Acids, Omega-3
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pharmacology
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Fish Oils
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chemistry
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Lead Poisoning
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physiopathology
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Long-Term Potentiation
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drug effects
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Perforant Pathway
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Rats
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Rats, Wistar
4.Differential Effects of High-carbohydrate and High-fat Diet Composition on Muscle Insulin Resistance in Rats.
Mu Ryun CHUN ; Youn Ju LEE ; Ki Hoon KIM ; Yong Woon KIM ; So Young PARK ; Keun Mi LEE ; Jong Yeon KIM ; Yoon Ki PARK
Journal of Korean Medical Science 2010;25(7):1053-1059
This study was conducted to evaluate whether the composition of carbohydrate or fat diet affects insulin resistance by measuring the muscle glucose transport rate. Both high-sucrose and high-starch diet with or without high-fat decreased insulin-stimulated glucose transport, but there were no significant differences among groups. Calorie intake in both high-sucrose and high-starch diet groups was higher than in chow group. The high-fat high-sucrose diet induced decrease in insulin-stimulated glucose transport was partially improved by supplement with fish oil. Calorie intake in high-fat high-sucrose and fish oil supplemented groups was higher than in chow group. The decreased insulin-stimulated glucose transport was accompanied by the increase in visceral fat mass, plasma triglyceride and insulin levels. These changes were improved by the supplement with fish oil. These results demonstrate that the composition of fat in diet is clearly instrumental in the induction of muscle insulin resistance. However, in high carbohydrate diet, it is likely that the amount of calorie intake may be a more important factor in causing insulin resistance than the composition of carbohydrate. Thus, the compositions of carbohydrate and fat in diet differentially affect on muscle insulin resistance.
Animals
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Blood Glucose/metabolism
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Body Weight
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Diet
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Dietary Carbohydrates/*pharmacology
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Dietary Fats/*pharmacology
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Dietary Supplements
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Energy Intake/drug effects
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Fish Oils/pharmacology
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Insulin/blood
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Insulin Resistance/*physiology
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Intra-Abdominal Fat/drug effects/metabolism
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Male
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Muscle, Skeletal/*drug effects/physiology
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Rats
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Rats, Sprague-Dawley