1.Comparison of advanced stage mucinous epithelial ovarian cancer and serous epithelial ovarian cancer with regard to chemosensitivity and survival outcome: a matched case-control study.
Emine KARABUK ; M Faruk KOSE ; Deniz HIZLI ; Salih TASKIN ; Burak KARADAG ; Taner TURAN ; Nurettin BORAN ; Ahmet OZFUTTU ; U Firat ORTAC
Journal of Gynecologic Oncology 2013;24(2):160-166
OBJECTIVE: The aim of this study was to compare clinicopathologic characteristics, surgery outcomes and survival outcomes of patients with stage III and IV mucinous epithelial ovarian cancer (mEOC) and serous epithelial ovarian carcinoma (sEOC). METHODS: Patients who had surgery for advanced stage (III or IV) mEOC were evaluated retrospectively and defined as the study group. Women with sEOC who were matched for age and stage of disease were randomly chosen from the database and defined as the control group. The baseline disease characteristics of patients and platinum-based chemotherapy efficacy (response rate, progression-free survival and overall survival [OS]) were compared. RESULTS: A total of 138 women were included in the study: 50 women in the mEOC group and 88 in the sEOC group. Patients in the mEOC group had significantly less grade 3 tumors and CA-125 levels and higher rate of para-aortic and pelvic lymph node metastasis. Patients in the mEOC group had significantly less platinum sensitive disease (57.9% vs. 70.8%; p=0.03) and had significantly poorer OS outcome when compared to the sEOC group (p=0.001). The risk of death for mEOC patients was significantly higher than for sEOC patients (hazard ratio, 2.14; 95% confidence interval, 1.34 to 3.42). CONCLUSION: Advanced stage mEOC patients have more platinum resistance disease and poorer survival outcome when compared to advanced stage sEOC. Therefore, novel chemotherapy strategies are warranted to improve survival outcome in patients with mEOC.
Case-Control Studies
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Disease-Free Survival
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Female
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Humans
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Lymph Nodes
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Mucins
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Neoplasm Metastasis
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Neoplasms, Glandular and Epithelial
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Ovarian Neoplasms
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Platinum
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Retrospective Studies
2.Prognostic Significance of Retroperitoneal Lymphadenectomy, Preoperative Neutrophil Lymphocyte Ratio and Platelet Lymphocyte Ratio in Primary Fallopian Tube Carcinoma: A Multicenter Study.
Kemal GUNGORDUK ; Ibrahim E ERTAS ; Aykut OZDEMIR ; Emrah AKKAYA ; Elcin TELLI ; Salih TASKIN ; Mehmet GOKCU ; Ahmet Baris GUZEL ; Tufan OGE ; Levent AKMAN ; Tayfun TOPTAS ; Ulas SOLMAZ ; Askin DOGAN ; Mustafa Cosan TEREK ; Muzaffer SANCI ; Aydin OZSARAN ; Tayyup SIMSEK ; Mehmet Ali VARDAR ; Omer Tarik YALCIN ; Sinan OZALP ; Yusuf YILDIRIM ; Firat ORTAC
Cancer Research and Treatment 2015;47(3):480-488
PURPOSE: The purpose of this study is to evaluate the prognostic role of preoperative neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) and the need for para-aortic lymphadectomy in patients with primary fallopian tube carcinoma (PFTC). MATERIALS AND METHODS: Ninety-one patients with a diagnosis of PFTC were identified through the gynecologic oncology service database of six academic centers. Clinicopathological, surgical, and complete blood count data were collected. RESULTS: In univariate analysis, advanced stage, suboptimal surgery, and NLR > 2.7 were significant prognostic factors for progression-free survival, whereas in multivariate analysis, only advanced stage and suboptimal surgery were significant. In addition, in univariate analysis, cancer antigen 125 > or = 35 U/mL, ascites, advanced stage, suboptimal surgery, NLR > 2.7, PLR > 233.3, platelet count > or =400,000 cells/mm3, staging type, and histological subtype were significant prognostic factors for overall survival (OS); however, in multivariate analysis, only advanced stage, suboptimal surgery, NLR > 2.7, and staging type were significant. Inclusion of pelvic and para-aortic lymphadenectomy in surgery showed significant association with longer OS, with a mean and median OS of 42.0 months and 35.5 months (range, 22 to 78 months), respectively, vs. 33.5 months and 27.5 months (range, 14 to 76 months), respectively, for patients who underwent surgery without para-aortic lymphadenectomy (hazard ratio, 3.1; 95% confidence interval, 1.4 to 5.7; p=0.002). CONCLUSION: NLR (in both univariate and multivariate analysis) and PLR (only in univariate analysis) were prognostic factors in PFTC. NLR and PLR are inexpensive and easy tests to perform. In addition, patients with PFTC who underwent bilateral pelvic and para-aortic lymphadenectomy had longer OS.
Ascites
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Blood Cell Count
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Blood Platelets*
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Diagnosis
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Disease-Free Survival
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Fallopian Tubes*
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Female
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Humans
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Lymph Node Excision*
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Lymphocytes*
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Multivariate Analysis
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Neutrophils*
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Platelet Count