1.A Case of Combination Therapy with Finasteride and Low Dose Dutasteride in the Treatment of Androgenetic Alopecia.
Suk Young LEE ; Sin Wook CHUN ; Jong Baik KIM ; Byung In RO
Korean Journal of Dermatology 2017;55(2):147-148
No abstract available.
Alopecia*
;
Dutasteride*
;
Finasteride*
2.Changes in Prostate Volume, Transitional Zone Volume and PSA after Cessation of the Finasteride.
Korean Journal of Urology 1999;40(11):1519-1524
PURPOSE: Finasteride is an inhibitor of human 5alpha-reductase, which results in a decrease in plasma and intraprostatic dihydrotestosterone(DHT) level. We investigated the changes of prostate volume(PV), transitional zone volume(TV), and PSA during and after administration of finasteride. MATERIALS AND METHODS: From 1995, 32 BPH patients treated with finasteride underwent surveillance after cessation of finasteride. Surveillance included measurements of PV, TV and PSA every 3 to 6 months. The mean age of the patients was 66.7 years(57-73). The mean duration of treatment and cessation were 8.6 months(6-12) and 8.0 months(6-12), respectively. The changes in PV, TV, and PSA were compared. RESULTS: The mean initial PV, TV, PSA were 45.7cc, 22.5cc, 2.72ng/ml, respectively. After treatment, PV, TV, PSA were reduced to 72.7%, 67.1%, 64.7% and 68.0%, 61.4%, 57.3% and 59.4%, 55.0%, 52.5% of the original values at 3, 6 and 12 months, respectively. The reduction rate was maximum after the first 3 months(p=0.001). After discontinuing finasteride, PV, TV, PSA recovered to 71.0%, 71.2% 63.9% and 84.0%, 82.3%, 67.6% and 90.4%, 85.1%, 74.1% at 3, 6 and 12 months, respectively. The recovery rates of PV and TV after 3 and 6 months were equal. However, recovery rate of PSA was maximum at 3 months and after then, constant until 12 months. CONCLUSIONS: During first 3 months` treatment, the decreasing rates of PV, TV and PSA were very considerable, after then, reduced. After cessation of medication the recovery rates of PV, TV were constant during first 6 months but PSA was maximum at first 3 months. The changes in clinical parameters during administration were fully recovered but it took slightly longer periods after cessation compared to those during of treatment. PSA is probably a predictor in the assessment of volume changes.
Finasteride*
;
Humans
;
Plasma
;
Prostate*
3.The Effect of Finasteride on Spermatogenesis in Rat.
Kyung Dae MIN ; Soo Bang RYU ; Kyu Yun AHN
Korean Journal of Urology 2000;41(7):878-884
No abstract available.
Animals
;
Finasteride*
;
Rats*
;
Spermatogenesis*
4.Finasteride Induced Cerebral Venous Thrombosis.
Dong Wan KANG ; Han Gil JEONG ; Hang Rai KIM ; Chan Young PARK ; Jung Min PYUN ; Do Yeon KIM ; Seung Hoon LEE
Journal of the Korean Neurological Association 2015;33(3):238-240
No abstract available.
Finasteride*
;
Risk Factors
;
Venous Thrombosis*
5.Comparative Study between the Effect of Finasteride & Castration on Rat Ventral Prostate.
Dong Deug KWON ; Joun Hwan LIM ; Bong Ryoul OH ; Soo BANG ; Yang Il PARK
Journal of the Korean Continence Society 1997;1(1):35-35
No abstract available.
Animals
;
Castration*
;
Finasteride*
;
Prostate*
;
Rats*
6.Two Cases of ReVersible Bilateral Painful Gynecomastia Induced by 1mg Oral Finasteride(Propecia(R)).
Beom Joon KIM ; Yu Jin KIM ; Byung In RO
Korean Journal of Dermatology 2003;41(2):232-234
Oral finasteride(Propecia(R)), 1mg/day, has been widely used as an effective treatment for male androgenetic alopecia since it had been approved by the Food and Drug Administration(FDA) of U.S. in December 1997. Gynecomastia has been one of the most common adverse effects in the patients who were taking 5mg of oral finasteride(Proscar(R)). Recently, several cases of unilateral or bilateral finasteride induced gynecomastia have also been reported in 1mg of oral finasteride(Propecia(r)). We report two cases of finasteride(Propecia(R)) induced painful bilateral gynecomastia, which are the first published documentations in Korea.
Alopecia
;
Documentation
;
Finasteride
;
Gynecomastia*
;
Humans
;
Korea
;
Male
7.Efficacy of Finasteride 1.25 mg on Female Pattern Hair Loss; Pilot Study.
Won Jeong KIM ; Margaret SONG ; Hyun Chang KO ; Byung Soo KIM ; Moon Bum KIM
Annals of Dermatology 2012;24(3):370-372
No abstract available.
Female
;
Finasteride
;
Hair
;
Humans
;
Pilot Projects
8.Effect of Finasteride According to the Histological Types of Benign Prostatic Hyperplasia as Predicted by Transrectal Ultrasonography.
Jeong Kee LEE ; Tae Hyo KIM ; Hong Bang SHIM
Korean Journal of Urology 2002;43(11):944-948
PURPOSE: Finasteride is being used as a medical therapy of benign prostatic hyperplasia (BPH), but there are no appropriate selection criteria for finasteride therapy. Our objective was to determine the usefulness of finasteride according to histological nature of the BPH, as determined by the transrectal ultrasonography (TRUS) findings. MATERIALS AND METHODS: Forty-two patients with symptomatic BPH were treated with finasteride (5mg/day) for more than 6 months. The patients were categorized into two groups of 21, according to their TRUS findings: the stromal, and the glandular, component dominant groups. The changes in prostate volume (PV), transition zone volume (TZV) and transition zone index (TZI) of each group, following at least 6 months of finasteride treatment, were evaluated and compared. RESULTS: In the stromal group the PV, TZV and TZI decreased from 69.3 11.5cc to 65.6 9.3cc, 43.5 13.2cc to 40.8 8.8cc and 0.63 to 0.62, respectively, but these changes were not statistically significant. While, in the glandular group, the PV, TZV and TZI decreased from 67.4+/-26.7cc to 56.2+/-25.2cc, 43.9+/-24.9cc to 32.4+/-19.9cc, and 0.63 to 0.54 (P<0.05), respectively. There was a linear correlation, only in the glandular group, between the TZI and TZV reductions following finasteride therapy (R=0.47, p=0.009). CONCLUSIONS: We suggest the prediction of the histological nature of BPH, by TRUS, would be helpful prior to the initiation finasteride treatment for effective reduction in the prostate volume with BPH. The effective reduction in the volume of the prostate in BPH would be possible only in glandular component dominant patients, as discriminated by TRUS.
Finasteride*
;
Humans
;
Patient Selection
;
Prostate
;
Prostatic Hyperplasia*
;
Ultrasonography*
9.Finasteride Treatment of Female Patterned Hair Loss in Postmenopausal Women.
Ji Young AHN ; Sung Hyun CHO ; Myeung Nam KIM ; Byung In RO
Korean Journal of Dermatology 2006;44(9):1094-1097
Finasteride, an inhibitor of type II 5alpha-reductase, inhibits conversion of testosterone to dihydrotestosterone (DHT), resulting in a decrease in serum and scalp DHT levels which are believed to be pathogenic in androgenic alopecia. Oral finasteride has been shown to be effective in the treatment of hair loss in men, while its efficacy in women has remained controversial. Herein, we report 10 cases of female patterned hair loss in postmenopausal women treated with 1 mg/day of finasteride.
Alopecia
;
Dihydrotestosterone
;
Female*
;
Finasteride*
;
Hair*
;
Humans
;
Male
;
Scalp
;
Testosterone
10.An Economic Evaluation of Pharmacological Therapy and Transurethral Resection of the Prostate for the Treatment of Benign Prostatic Hyperplasia.
Doo Jin LEE ; Jin Seon CHO ; Byung Soo CHUNG
Korean Journal of Urology 2002;43(7):619-623
PURPOSE: An economic analysis of pharmacological therapy and transurethral resection of the prostate (TURP) for patients with benign prostatic hyperplasia (BPH) was conducted. MATERIALS AND METHODS: Twenty six patients had undergone TURP from January to June 2000 were enrolled in this study. The costs associated with this group of patients were compared with those of 7 patients treated with medication (doxazosin, terazosin, tamsulosin, and finasteride only and alpha-blocker with finasteride). RESULTS: The mean cost for TURP was 1,900,000 won. The most expensive medical therapy was finasteride, which was followed by tamsulosin, terazosin, and doxazosin, with an estimated 12-month cost of 817,000won, 695,000won, 396,000won, and 372,000won respectively. The costs associated with doxazosin remained lower than those associated with TURP for approximately 5.3 years (the corresponding break-even point was 2.4 years for finasteride vs. TURP). CONCLUSIONS: Among the pharmacological therapies, doxazosin is the most cost effective. TURP was more cost effective than doxazosin therapy after 5.3 years. In view of the cost-effectiveness, TURP may be considered as the mode of primary therapy for the patients with severe symptoms of BPH.
Doxazosin
;
Finasteride
;
Humans
;
Prostate*
;
Prostatic Hyperplasia*
;
Transurethral Resection of Prostate