Cross sectional retrospective study of 20 cases of Fibrous dysplasia confirmed by pathological result at Muculoskeletal Pathology Ward, Traumatologic and Orthopedic Center Hå ChÝ Minh City we noted a female predominance with M/F ratio = 13/7; ages group from 8 to 58 year old average age 24 year old. Polyostotic F.D exists only in 5 cases while the rest 15 cases are Monostotic F.D Tibia and femur are the most affected bones. Depend on the sites of lesion, we have 4 main patterns of bone lesion: 1. Pure lytic lesion. 2. Ground glass lesion. 3. Sclerotic lesion. 4. Complex lesion. From the determining factors as sex, age, sites of lesions, pattern of bone lesions, we try to find some criteria for the diagnosis of FD disease in Vietnamese patients.
Fibrous Dysplasia of Bone ; Diagnosis ; epidemiology

A retrospective and cross sectional study was carried out in 23 cases of Fibrous dysplasia (FD) of bone diagnosed in Musculoskeletal Pathology ward, Traumatic & Orthopedic Center, HCMC, we noticed that Male/female ratio = 1:2.2, the peak age is the 2nd decade Monostolic FD: Pylyostotic FD=12:11. In monostotic FD, the lower limb is most affected (83.3%) in which tibia is the most common bone involved, while polyostotic FD is most encountered in the femur and pelvis. The most common X ray finding is the bone expansion lesion (79.6%), followed by mixtelytic and sclerotic osseous lesions, ground glass aspect (39%). The zone of transition is narrow (77.2%) and sclerotic margin (63.6%) are other common findings. "Crook shepherd" deformity is classic sign in femoral FD.
Fibrous Dysplasia of Bone ; Diagnosis ; epidemiology

Fibrous dysplasia of bone is a relatively rare condition characterized by fibrous tissue replacement of skeleton, usually not disabling, of slow progress, and showing a tendency to become arrested. It may be monostotic (confined to one bone) or Polyostotic (situated in many bones). The etiology of fibrous dysplasia is unkown but it is now believed to be a developmental error in which primitive fibrous tissue proliferates within the bony medulla and encroaches upon the cortex from within. This paper reports the one case of polyostotic fibrous dysplasia. The diagnosis was made by clinical, radiological and histological findings. The review of literatures was made briefly.
Diagnosis ; Fibrous Dysplasia of Bone ; Fibrous Dysplasia, Polyostotic ; Skeleton

Fibrous dysplasia is an uncommon benign disorder of unknown etiology. The disease was first described by McCune and Albright in separate publications in 1937. The term, fibrous dysplasia was suggested by Lichtenstein in 1938. The disease has since been found to have 3 different variants: monostotic, polyostotic, and McCune-Albright syndrome. It is a slowly progressive bony disorder where normal bone is replaced by abnormal fibrosseous tissue. Involvement of fibrous dysplasia of the temporal bone is usually unilateral. The squama becomes thickened and the pneumatic system is obliterated. Because fibrous dysplasia shows a predilection for the facial and cranial bone, where it causes deformity and dysfunction. In this paper, we report a case of fibrous dysplasia of the temporal bone. We discuss the characterisitic features of this specific location of the disease, the differential diagnosis, and the treatment policy. We also address the issue of vertigo.
Congenital Abnormalities ; Diagnosis, Differential ; Dizziness ; Fibrous Dysplasia, Monostotic* ; Fibrous Dysplasia, Polyostotic ; Hearing Loss* ; Hearing* ; Temporal Bone* ; Vertigo

OBJECTIVE: To study the clinical manifestation, radiograph features, pathology, diagnosis and treatment of fibrous dysplasia in cranial bone. METHOD: A case of fibrous dysplasia involving sphenoid and occipital is reported and literature were reviewed. RESULT: The most common complaint were headache, proptosis, diplopia, or visual changes. Distinguishing features of fibrous dysplasia on CT include "ground-glass" appearance, bone fiber anisotrophy, aneurysmal bone cyst formation and thickness of the cranial cortices. Fibrous dysplasia could be exactly diagnosed by pathology. Computed tomography was also a choice for diagnosis. CONCLUSION Fibrous dysplasia involving the cranial bone can present in myriad ways. Modern imaging modalities and histopathologic analysis is required to make accurate diagnosis. Surgery, particularly in a challenging region such as sphenoid and occipital bone, should preserve the existing function for the patients with functional impairment or a cosmetic deformity.
Adult ; Fibrous Dysplasia, Polyostotic ; diagnosis ; diagnostic imaging ; pathology ; Humans ; Male ; Occipital Bone ; Radiography ; Sphenoid Bone

Fibrous dysplasia of the spine is very rarely observed. We reported a case of a 57-year-old woman, who presented with neck and bilateral shoulder pain with histologically confirmed fibrous dysplasia, involving the first and second thoracic vertebrae. Clinical and radiological findings were not specific for fibrous dysplasia. The histological biopsy was required for a confirmed diagnosis. Endocrine and metabolic evaluations are required to rule out diseases such as hyperthyroidism, Cushing syndrome and osteomalacia. Fibrous dyplasia can be managed by appropriate medical and surgical treatments based on the patient's neurological status and symptoms. Our patient was given intravenous pamidronate 60mg/day for 3 days. After 9 months, her initial symptoms were improved, but computed tomography scan of the thoracic spine showed no change of the lesions.
Biopsy ; Cushing Syndrome ; Diagnosis ; Female ; Fibrous Dysplasia of Bone ; Fibrous Dysplasia, Polyostotic* ; Follow-Up Studies* ; Humans ; Hyperthyroidism ; Middle Aged ; Neck ; Osteomalacia ; Shoulder Pain ; Spine* ; Thoracic Vertebrae

Fibrous dysplasia of bone is a skeletal developmental anomaly of unknown etiology characterized by single ormultiple areas of fibrous tissue replacement of medullary cavity of one or more bones. The disease may belocalized to single bone (monostotic form), of may affect multiple bone(polyostotic form). Eighteen cases offibrous dysplasia diagnosed by roentgenologic or histologic assessments at Chosum University Hospital ChonnamUniversity hospital and kwangju Christian Hospital during recent ten years were analyzed clinically andradiologically. The results were as follows; 1. 16 cases of them had monostotic involvement, and 2 cases showedpolyostotic disease, but none of our series presented Albright's syndrome. 2. The male to female ratio in thisseries was 10:8, but then 2 polyostotic forms of them were femals. In age distribution, peak incidence at the timeof diagnosis was in the age group of second decade (10 cases). 3. Maxilla (6 cases ) and femur (4 cases) werefrequently involved sites in patients with monostotic lesion, whereas polyostotic lesions diffusely affectedskull, pelvis, ribs and limb bones. 4. The clinical symptoms according to the extent and site of disease were veryvariable, which were localized painless or painful swelling, nasal obstruction, deformity of face or extremity andincidentally during routine roentgen study. 5. The chemical abnormality of blood serum was moderate degree ofelevated serum alkaline phosphatase in only one patients with monostotic lesion. 6. The main radiologic findingsof fibrous dysplasia were relatively well circumscribed single or multiloculated cystlike appearance, boneexpansion, cortical thinning and/or erosion, bony deformity and pathologic fracture, but especially in maxilla,dense homogenous area with expanding lesion was observed in our series.
Age Distribution ; Alkaline Phosphatase ; Congenital Abnormalities ; Diagnosis ; Extremities ; Female ; Femur ; Fibrous Dysplasia of Bone ; Fibrous Dysplasia, Polyostotic ; Fractures, Spontaneous ; Gwangju ; Humans ; Incidence ; Male ; Maxilla ; Nasal Obstruction ; Pelvis ; Ribs ; Serum

Seventy-two cases of benign fibro-osseous lesions of the jaws were reassessed, and a modified classification is proposed that may be helpful in their understanding and management. The anatomical distribution of these cases is described and compared to previously reported cases. The histogenesis of each particular lesion is also discussed. Correlative analysis of histopathologic and oral radiographic features is essential for definitive diagnosis.
Adolescent ; Adult ; Aged ; Child ; Female ; Fibrous Dysplasia of Bone/classification/*diagnosis/etiology ; Human ; Jaw Diseases/classification/*diagnosis/etiology ; Male ; Middle Age

Fibrous dysplasia is a benign, bony abnormality that is usually asymptomatic. A 41-year-old male with minimal symptoms presented at this hospital with abnormal findings incidentally seen in his ribs on the chest radiograph. A skeletal survey showed numerous, osteolytic lesions throughout multiple bones. Diagnostic processes for malignancy of undefined primary origin (MUO) were performed in order to identify the underlying primary neoplasm, although abnormal findings were not seen except for multiple bone lesions. A computed tomography guided bone biopsy was performed on his left rib. The final diagnosis was fibrous dysplasia. This case demonstrates that fibrous dysplasia should be considered in the differential diagnosis in young patients with multiple, osteolytic lesions and without a prior history suggesting malignancy.
Adult ; Biopsy ; Bone Neoplasms ; Diagnosis ; Diagnosis, Differential ; Fibrous Dysplasia, Polyostotic* ; Humans ; Male ; Neoplasm Metastasis* ; Radiography, Thoracic ; Ribs

Oncogenic osteomalacia is an unusual and rare clinicopathologic syndrome characterized by mesenchymal tumors that apparently produce osteomalacia and biochemical abnormalities consisting of hypophosphatemia, normocalcemia, and increased levels of alkaline phosphatase. We collected from the Mayo Clinic files and from our consultation files the records for 17 cases of osteomalacia associated with bone lesions. There were five cases of fibrous dysplasia, three of hemangiopericytoma, and two of phosphaturic mesenchymal tumor. There was one case each of osteosarcoma, chondroblastoma, chondromyxoid fibroma, malignant fibrous histiocytoma, giant cell tumor, metaphyseal fibrous defect, and hemangioma. In this study we can figure out that the most common characteristic histologic features of our cases were hemangiopericytomatous vascular proliferation, fine lace-like stromal calcification, and stromal giant cells. In most of the cases, the clinical and biochemical symptoms and signs resolved soon after complete resection of the lesion. When the lesion recurred or metastasized, the symptoms and signs also recurred.
Adolescent ; Adult ; Aged ; Bone Neoplasms/classification/*complications/diagnosis ; Child ; Child, Preschool ; Female ; Fibrous Dysplasia of Bone/classification/*complications/diagnosis ; Follow-Up Studies ; Human ; Male ; Middle Age ; Osteomalacia/*etiology/pathology