Idiopathic pulmonary fibrosis (IPF) is the most common interstitial lung disease (ILD) of unknown causes, which is characterized by pulmonary fibrosis. The median survival period after diagnosis is about 2-4 years. In recent years, the incidence rate of lung cancer associated with IPF (IPF-LC) is increasing, and the prognosis is worse than that of IPF alone. Pulmonary fibrosis may be closely associated with the occurrence and development of lung cancer. Although the pathogenesis of IPF-LC is still unclear, the current research shows that there are similarities between the pathogenesis of these two diseases at molecular and cellular levels. At present, the research on the cellular and molecular mechanism of lung cancer related to pulmonary fibrosis has become the focus of researchers' attention. This article reviews the related literature, focusing on the latest status of the cellular and molecular mechanisms and treatment of IPF-LC, hoping to help clinicians understand IPF-LC.
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Humans ; Idiopathic Pulmonary Fibrosis/complications* ; Lung Neoplasms/complications*

Humans ; Mediastinal Emphysema ; complications ; Paraquat ; poisoning ; Poisoning ; complications ; Pulmonary Fibrosis ; complications ; Subcutaneous Emphysema ; complications

We experienced a case of chronic fibrosing pancreatitis in an 18/12-year-old girl, which was idiopathic because there were no familial back ground, no cystic fibrosis of pancrease, no ductal anomalies and obstruction. The patient presented intermittent colicky abdominal pain and progressive obstructive jaundice, but T-tube drainage and removal of the lymph nodes around the common bile duct relieved her symptoms and disease process. This seems to be the first case reported in a Korean child. Idiopathic fibrosing pancreatitis should be considered in the differential diagnosis of abdominal pain with obstructive jaundice in children.
Abdominal Pain/complications ; Female ; Fibrosis ; Humans ; Infant ; Jaundice, Chronic Idiopathic/complications ; Pancreatitis/complications/*pathology

Adolescent ; Cough ; complications ; Fatal Outcome ; Female ; Fever ; complications ; Humans ; Pulmonary Fibrosis ; complications ; diagnosis

To evaluate and compare the clinical results of implantation of the AcrySof(r) with Hydrophilic Acrylic IOLs in early postoperative period(to 2 months), we retrospectively analyzed 34patients who had taken clear cornea incision and had been implanted with AcrySof(r)IOL in one eye and Hydrophilic Acrylic IOL in the other eye. There were no stastically significant difference in postoperative best corrected visual acuity, preoperative and postopearative astigmatic changes between AcrySof(r) and Hydrophilic Acrylic IOLs. But, the rates of postoperative capsular fibrosis and contracture of Hydrophilic Acrylic IOL was higher than those of AcrySof(r) IOL as well as postoperative complications. In conclusion, in the degree and rate of after-cataract, AcrySof(r)IOLs are more useful than Hydrophilic Acrylic IOLs. ;therefore, more excellent in long term visual prognosis. Further studies will be needed for the evaluation of clinical safety and efficacy.
Contracture ; Cornea ; Fibrosis ; Postoperative Complications ; Prognosis ; Retrospective Studies ; Visual Acuity

PURPOSE: To compare the clinical results of one-piece Acryl IOL C160 (Opthalmed(R), USA) with those of three-piece Acryl IOL AcrySof (MA60BM, Alcon(R), USA) in complicated cataracts. METHODS: In one eye of 30 patients with complicated cataracts, Acryl-C160 IOL was implanted and AcrySof IOL in the other eye. The degrees of anterior capsular fibrosis and posterior capsular opacification together with IOL decentration were evaluated for 12months prospectively. RESULTS: In 9 of 30 eyes with Acryl-C160 IOL, significant fibrosis of anterior capsule was seen as early as 1 month postoperatively. At 12 months, 15 eyes had more than grade 3 of capsular fibrosis. Five eyes had severe contraction of IOL haptic and one eye had significant IOL degradation to be exchanged. On the contrary, 2 of 30 eyes implanted with AcrySof IOL had moderate degree of capsular fibrosis. CONCLUSIONS: In complicated cataracts, Acryl-C160 IOL developed higher incidence of postoperative complications due to the inflammation and poor memory function of IOL haptic. The type and design of IOL haptic together with the function of IOL optic should be considered in selecting the IOLs best fitted in complicated cataracts.
Cataract* ; Fibrosis ; Humans ; Incidence ; Inflammation ; Memory ; Postoperative Complications ; Prospective Studies

Epithelial-mesenchymal transition plays an important role in the development and progression of endometriosis. Mesenchymal-epithelial transition is involved in forming localized lesions of endometriosis, while EMT is involved in the injury, repair and fibrosis induced by local inflammation of endometriosis and the process of cell invasion and metastasis. The studies of signal transduction pathway and related proteins of epithelial-mesenchymal transition in the process of endometriosis may provide new targets for diagnosis and treatment of endometriosis.
Endometriosis ; complications ; etiology ; pathology ; physiopathology ; Epithelial-Mesenchymal Transition ; physiology ; Female ; Fibrosis ; complications ; Humans ; Inflammation ; complications ; Signal Transduction ; physiology

Cystic fibrosis (CF) is a fatal autosomal-recessive disease caused by mutations in the CF transmembrane conductance regulator (CFTR) gene. CF is characterized by recurrent pulmonary infection with obstructive pulmonary disease. CF is common in the Caucasian population but is rare in the Chinese population. The symptoms of early-stage CF are often untypical and may sometimes manifest as Bartter syndrome (BS)-like hypokalemic alkalosis. Therefore, the ability of doctors to differentiate CF from BS-like hypokalemic alkalosis in Chinese infants is a great challenge in the timely and accurate diagnosis of CF. In China, sporadic CF has not been diagnosed in children younger than three years of age to date. Three infants, who were initially admitted to our hospital over the period of June 2013 to September 2014 with BS-like hypokalemic alkalosis, were diagnosed with CF through exome sequencing and sweat chloride measurement. The compound heterozygous mutations of the CFTR gene were detected in two infants, and a homozygous missense mutation was found in one infant. Among the six identified mutations, two are novel point mutations (c.1526G > C and c.3062C > T) that are possibly pathogenic. The three infants are the youngest Chinese patients to have been diagnosed with sporadic CF at a very early stage. Follow-up examination showed that all of the cases remained symptom-free after early intervention, indicating the potential benefit of very early diagnosis and timely intervention in children with CF. Our results demonstrate the necessity of distinguishing CF from BS in Chinese infants with hypokalemic alkalosis and the significant diagnostic value of powerful exome sequencing for rare genetic diseases. Furthermore, our findings expand the CFTR mutation spectrum associated with CF.
Alkalosis ; complications ; Bartter Syndrome ; China ; Cystic Fibrosis ; diagnosis ; genetics ; Cystic Fibrosis Transmembrane Conductance Regulator ; genetics ; Diagnosis, Differential ; Exome ; Female ; Humans ; Hypokalemia ; complications ; Infant ; Male ; Mutation

PURPOSE: To evaluate the efficacy and intraocular lens (IOL) stability of vitrectomy combined with the surgical removal of anterior capsular opacity (ACO) and posterior capsular opacity (PCO). METHODS: Forty-four pseudophakic eyes of 43 patients with retinal disorders underwent vitrectomy with surgical removal after cataract diagnosis. Nineteen eyes of 19 patients (group 1) had ACO and PCO removed while 25 eyes of 24 patients (group 2) had only PCO removed. Total removal of the entire lens capsule, except for the area around the haptics, was performed when capsular opacity with fibrosis was observed around the capsulorrhexis margin. LogMAR best corrected visual acuity (BCVA), intraoperative complications and postoperative complications were compared. RESULTS: The retina was flat and postoperative BCVA improved in both groups. Intraoperative complications of IOL dislocation occurred in 3 eyes (15.8%) in group 1 and in 1 eye (4.0%) in group 2 (p=0.178). Among the 4 IOLs, 3 were open-loop haptic IOLs and 1 was a closed-loop haptic IOL. Late postoperative complications of IOL capture occurred in 1 eye (5.3%) in group 1. CONCLUSIONS: Removal of ACO and PCO for better visualization of the peripheral retina resulted in an improved visual recovery while intraoperative complications and postoperative complications were comparable to PCO removal alone. Removal limited to the optic zone would be more stable when considering any adhesion between the lens capsule and the IOL.
Capsulorhexis ; Cataract ; Dislocations ; Eye ; Fibrosis ; Humans ; Intraoperative Complications ; Lenses, Intraocular ; Postoperative Complications ; Retina ; Retinaldehyde ; Visual Acuity ; Vitrectomy

To evaluate the clinical results of implantation of Acrysof foldable intraocular lens[IOL], we retrospectively analyzed 814 patients who had been implanted with Acrysof IOLs in their eyes and followed-up over 6months postoperatively. Postoperative conditions such as best corrected visual acuity[BCVA], postoperative complications and capsular fibrosis were evaluated. Postoperative BCVA, with measurement above 0.7 was 83%and above 0.5 was 92%.If there was no ocular pathology, BCVA with measurement above 0.7 was 96.5%.Postoperative complications included 9.8%[80 cases]of posterior capsular opacity, 3.2%[28 cases]of microvacuole, and also anterior capsule contracture, haptic damage.7 cases of posterior capsular opacity[totally 80 cases]required Nd;Yag laser posterior capsulotomy.Capsular fibrosis[61.8%]was divided to 4 grades.Most of them were grade I or IIand above grade was 9.8%. In conclusion, the Acrysof IOL implantation showed good visual outcome and few postoperative complications, especially in PCO, it had excellent results.So, it will show excellent longterm visual prognosis including visual quality.
Contracture ; Fibrosis ; Humans ; Lens Implantation, Intraocular* ; Lenses, Intraocular* ; Pathology ; Postoperative Complications ; Prognosis ; Retrospective Studies