Fibrosarcoma is a rare malignant tumor in the larynx. It is quite different from epidermoid carcinoma seen most frequently in the larynx in the aspect of invasive behavior; metastatic route and treatment modality. This paper presents a case of pyriform sinus fibrosarcoma with a brief review of literature.
Adult ; Case Report ; Fibrosarcoma/pathology* ; Human ; Laryngeal Neoplasms/pathology* ; Male

Adult ; Female ; Fibrosarcoma ; diagnosis ; pathology ; Heart Neoplasms ; diagnosis ; pathology ; Humans

A low grade fibromyxoid sarcoma is a rare soft tissue tumor that has a tendency to develop in the deep soft tissue of young adults and the potential for local recurrence or distant metastasis. There have been several case reports and sporadic reports in the literature. However, only 1 case has been reported in Korea but without a follow-up result. We describe a 54-year-old female patient with a low-grade fibromyxoid sarcoma of the thigh that had been growing slowly for 34 years. A marginal resection of this tumor was performed. Currently, the patient is doing well without evidence of local recurrence or distant metastasis at 5 years after surgery.
Female ; Fibrosarcoma/*pathology/surgery ; Humans ; Middle Aged ; Soft Tissue Neoplasms/*pathology/surgery ; Thigh/*pathology/surgery

Diagnosis, Differential ; Fibrosarcoma ; congenital ; diagnosis ; pathology ; Humans ; Infant ; Male ; Soft Tissue Neoplasms ; congenital ; diagnosis ; pathology

Myxoinflammatory fibroblastic sarcoma (MIFS) is a rare low-grade, malignant soft tissue tumor that is usually observed in the extremities of adult patients. Magnetic resonance imaging findings for this tumor type have rarely been reported. We report a case involving the distal left femur of a middle-aged man and tumoral invasion of the bone, which, to our knowledge, has been previously described only once. He was treated with distal femoral tumor resection and reconstruction with a modular prosthesis. Histopathologic diagnosis confirmed MIFS. We reviewed literature of the diagnostic imaging and bone invasion findings associated with this tumor type.
Femoral Neoplasms ; pathology ; Fibrosarcoma ; pathology ; Humans ; Magnetic Resonance Imaging ; Male ; Middle Aged

Humans ; Solitary Fibrous Tumors/pathology* ; Osteosarcoma/pathology* ; Fibrosarcoma ; Bone Neoplasms/surgery*

OBJECTIVETo evaluate the effect of tissue factor (TF) in extravascular migration of fibrosarcoma cells and hematogenous metastasis.

METHODSThe expression of tissue factor in fibrosarcoma HT1080 cells was analyzed by flow cytometry. The extravascular migration of fibrosarcoma cells was observed in a constructed monolayer vascular endothelial cells and extra-cellular matrix model.

RESULTTissue factor was highly expressed in HT1080 cells. HT1080 migrated and passed through the monolayer vascular endothelial cells to the collagen gel in a time-dependent manner. Anti-TF antibody inhibited extravascular migration of fibrosarcoma cells and the inhibition was concentration-dependent (P<0.05).

CONCLUSIONTissue factor may enhance hematogenous metastasis through extravascular migration of fibrosarcoma cells.

Cell Movement ; Cells, Cultured ; Endothelial Cells ; Fibrosarcoma ; metabolism ; pathology ; Humans ; Neoplasm Metastasis ; Thromboplastin ; metabolism ; physiology

Female ; Fibrosarcoma ; diagnosis ; pathology ; Humans ; Magnetic Resonance Imaging ; Middle Aged ; Neoplasm Metastasis

Actins ; metabolism ; Bone Neoplasms ; metabolism ; pathology ; surgery ; Desmin ; metabolism ; Diagnosis, Differential ; Fibrosarcoma ; metabolism ; pathology ; Humans ; Leiomyosarcoma ; metabolism ; pathology ; surgery ; Male ; Middle Aged ; Neurilemmoma ; metabolism ; pathology ; Tibia ; Vimentin ; metabolism

Actins ; metabolism ; Arm ; Diagnosis, Differential ; Fibrosarcoma ; metabolism ; pathology ; Hamartoma ; metabolism ; pathology ; surgery ; Humans ; Infant ; Lipoma ; metabolism ; pathology ; Male ; Myofibromatosis ; metabolism ; pathology ; S100 Proteins ; metabolism ; Vimentin ; metabolism