1.Surgical treatment of severe generalized idiopathic gingival fibromatosis on mandible and maxilla:report of a case.
Yong Oh LEE ; Seon Hye MOON ; Hye Kyung SUH ; Hee Suck JANG ; Gong Uck SA ; No Bu PARK
Journal of the Korean Association of Oral and Maxillofacial Surgeons 1993;19(1):37-43
No abstract available.
Fibromatosis, Gingival*
;
Mandible*
2.Surgical treatment of severe generalized idiopathic gingival fibromatosis on mandible and maxilla:report of a case.
Yong Oh LEE ; Seon Hye MOON ; Hye Kyung SUH ; Hee Suck JANG ; Gong Uck SA ; No Bu PARK
Journal of the Korean Association of Oral and Maxillofacial Surgeons 1993;19(1):37-43
No abstract available.
Fibromatosis, Gingival*
;
Mandible*
3.Hereditary gingival fibromatosis: a three-generation case report.
Xiu-Fang HE ; Chun-Jiao XU ; Di TIAN ; Miao-Miao WANG ; Wen-Rui ZHANG ; Yi-Ting GUO
West China Journal of Stomatology 2020;38(1):104-107
Hereditary gingival fibromatosis (HGF) is a familial hereditary disease; while it is rare and usually benign, it is also characterized by the slow and progressive development of gingival tissue. This paper reports on the clinical examina-tion and history of HGF in a family of patients.
Fibromatosis, Gingival
;
Gingiva
;
Humans
4.Hereditary gingival fibromatosis: a case report.
West China Journal of Stomatology 2011;29(4):450-451
Hereditary gingival fibromatosis (HGF) is a rare hereditary condition characterized by a slow, progressive increase in the gingival tissue. A case of HGF was reported and relevant literature of HGF were reviewed.
Fibromatosis, Gingival
;
Gingiva
;
Humans
;
Male
6.The effect of non-surgical treatment in gingival enlargement.
Sang Jun KIM ; Jae Kwan LEE ; Heung Sik UM ; Beom Seok CHANG
The Journal of the Korean Academy of Periodontology 2009;39(1):103-108
PURPOSE: It is well recognized that gingival enlargement is induced by unwanted effect associated with three major drugs/drug groups - phenytoin, cyclosporine, and the calcium channel blockers. The present case report describes the effect and limitation of non-surgical treatment in gingival enlargement cases. MATERIALS AND METHODS: Three cases included 2 drug-influenced gingival enlargement patients and a idiopathic gingival fibromatosis patient. For the drug-influenced gingival enlargement patients, the medication was replaced with other medication. And then, all the patients were treated non-surgically. RESULTS: Drug-influenced gingival enlargements had been reduced after non-surgical treatment and the results were well-maintained. In the idiopathic gingival fibromatosis case, non-surgical treatment resulted in only limited reduction of gingival enlargement, and surgical periodontal treatment was unavoidable. CONCLUSION: These case reports indicated that non-surgical periodontal treatment with change in medication was effective in the treatment of drug-influenced gingival enlargements. Non-surgical approach can be considered as the primary management to reduce the gingival enlargement. If non-surgical treatment encounters a limitation, surgical treatment should be considered
Calcium Channel Blockers
;
Cyclosporine
;
Fibromatosis, Gingival
;
Humans
;
Nifedipine
;
Phenytoin
7.A Case of Idiopathic Gingival Fibromatosis and Hypertrichosis.
Seong Jin JEON ; Kwang KIM ; Young Soo CHAE ; Kee Suck SUH ; Sang Tae KIM
Korean Journal of Dermatology 1993;31(1):118-122
Idiopathic gingival fibromatosis is associated with other abnorma ities of which the most striking is hypertrichosis of variable degree. Gorlin and Pindborg described this condition as a distinct syndrome termed idiopathic gingival fibromatosis and hypertrichosis. We report a case of idiopathic gingival fibromatosis and hypertrichosis occuring in 34-year-old woman with enlarged gingival tissue, hypertrichosis, and enlargenment of the breasts, ears and nose. Laboratory tests including hormonal and chromosomal studies were all within normal limits. Histologically, the gingival hyperplastic tissue showed thick bundle of collagen fibers with few fibroblasts or capillaries and little or no inflammatory infiltrate.
Adult
;
Breast
;
Capillaries
;
Collagen
;
Ear
;
Female
;
Fibroblasts
;
Fibromatosis, Gingival*
;
Humans
;
Hypertrichosis*
;
Nose
;
Strikes, Employee
8.A Case of Idiopathic Gingival Fibromatosis and Hypertrichosis.
Seong Jin JEON ; Kwang KIM ; Young Soo CHAE ; Kee Suck SUH ; Sang Tae KIM
Korean Journal of Dermatology 1993;31(1):118-122
Idiopathic gingival fibromatosis is associated with other abnorma ities of which the most striking is hypertrichosis of variable degree. Gorlin and Pindborg described this condition as a distinct syndrome termed idiopathic gingival fibromatosis and hypertrichosis. We report a case of idiopathic gingival fibromatosis and hypertrichosis occuring in 34-year-old woman with enlarged gingival tissue, hypertrichosis, and enlargenment of the breasts, ears and nose. Laboratory tests including hormonal and chromosomal studies were all within normal limits. Histologically, the gingival hyperplastic tissue showed thick bundle of collagen fibers with few fibroblasts or capillaries and little or no inflammatory infiltrate.
Adult
;
Breast
;
Capillaries
;
Collagen
;
Ear
;
Female
;
Fibroblasts
;
Fibromatosis, Gingival*
;
Humans
;
Hypertrichosis*
;
Nose
;
Strikes, Employee
9.Double heterozygous pathogenic mutations in KIF3C and ZNF513 cause hereditary gingival fibromatosis.
Jianfan CHEN ; Xueqing XU ; Song CHEN ; Ting LU ; Yingchun ZHENG ; Zhongzhi GAN ; Zongrui SHEN ; Shunfei MA ; Duocai WANG ; Leyi SU ; Fei HE ; Xuan SHANG ; Huiyong XU ; Dong CHEN ; Leitao ZHANG ; Fu XIONG
International Journal of Oral Science 2023;15(1):46-46
Hereditary gingival fibromatosis (HGF) is a rare inherited condition with fibromatoid hyperplasia of the gingival tissue that exhibits great genetic heterogeneity. Five distinct loci related to non-syndromic HGF have been identified; however, only two disease-causing genes, SOS1 and REST, inducing HGF have been identified at two loci, GINGF1 and GINGF5, respectively. Here, based on a family pedigree with 26 members, including nine patients with HGF, we identified double heterozygous pathogenic mutations in the ZNF513 (c.C748T, p.R250W) and KIF3C (c.G1229A, p.R410H) genes within the GINGF3 locus related to HGF. Functional studies demonstrated that the ZNF513 p.R250W and KIF3C p.R410H variants significantly increased the expression of ZNF513 and KIF3C in vitro and in vivo. ZNF513, a transcription factor, binds to KIF3C exon 1 and participates in the positive regulation of KIF3C expression in gingival fibroblasts. Furthermore, a knock-in mouse model confirmed that heterozygous or homozygous mutations within Zfp513 (p.R250W) or Kif3c (p.R412H) alone do not led to clear phenotypes with gingival fibromatosis, whereas the double mutations led to gingival hyperplasia phenotypes. In addition, we found that ZNF513 binds to the SOS1 promoter and plays an important positive role in regulating the expression of SOS1. Moreover, the KIF3C p.R410H mutation could activate the PI3K and KCNQ1 potassium channels. ZNF513 combined with KIF3C regulates gingival fibroblast proliferation, migration, and fibrosis response via the PI3K/AKT/mTOR and Ras/Raf/MEK/ERK pathways. In summary, these results demonstrate ZNF513 + KIF3C as an important genetic combination in HGF manifestation and suggest that ZNF513 mutation may be a major risk factor for HGF.
Animals
;
Humans
;
Mice
;
Fibromatosis, Gingival/pathology*
;
Gingiva
;
Kinesins/genetics*
;
Mutation/genetics*
;
Phosphatidylinositol 3-Kinases/genetics*
10.Enamel renal syndrome with associated amelogenesis imperfecta, nephrolithiasis, and hypocitraturia: A case report.
Dhvani BHESANIA ; Ankit ARORA ; Sonali KAPOOR
Imaging Science in Dentistry 2015;45(3):181-185
Numerous cases of enamel renal syndrome have been previously reported. Various terms, such as enamel renal syndrome, amelogenesis imperfecta and gingival fibromatosis syndrome, and enamel-renal-gingival syndrome, have been used for patients presenting with the dental phenotype characteristic of this condition, nephrocalcinosis or nephrolithiasis, and gingival findings. This report describes a case of amelogenesis imperfecta of the enamel agenesis variety with nephrolithiasis in a 21-year-old male patient who complained of small teeth. The imaging modalities employed were conventional radiography, cone-beam computed tomography, and renal sonography. Such cases are first encountered by dentists, as other organ or metabolic diseases are generally hidden. Hence, cases of amelogenesis imperfecta should be subjected to advanced diagnostic modalities, incorporating both dental and medical criteria, in order to facilitate comprehensive long-term management.
Amelogenesis Imperfecta*
;
Amelogenesis*
;
Cone-Beam Computed Tomography
;
Dental Enamel Hypoplasia
;
Dental Enamel*
;
Dentists
;
Fibromatosis, Gingival
;
Humans
;
Kidney Diseases
;
Male
;
Metabolic Diseases
;
Nephrocalcinosis
;
Nephrolithiasis*
;
Phenotype
;
Radiography
;
Tooth
;
Young Adult