No abstract available.
Fibrin Tissue Adhesive* ; Fibrin*

No abstract available.
Dust* ; Fibrin Tissue Adhesive* ; Fibrin*

No abstract available.
Fibrin Tissue Adhesive* ; Fibrin* ; Transplants*

No abstract available.
Fibrin Tissue Adhesive* ; Fistula*

Objective: To determine the efficacy of human corneal lenticule from small incision lenticule extraction (SMILE) with single blood donor fibrin glue as corneal patch for sealing induced corneal penetrating wounds in cadaveric porcine eyes compared to suturing using 2 simple interrupted nylon 10-0 sutures. Methodology: This is an in vitro comparative experimental study using cadaveric porcine eyes. Twenty (20) porcine eyes were randomized into control and treatment groups. A 3-mm metal keratome was used to create a fullthickness incision with the keratome angled perpendicular to the central cornea. Seidel’s test was done to confirm leakage. An anterior chamber maintainer connected to the Centurion® Vision System (Alcon, USA) was inserted into a peripheral corneal incision with the infusion turned off. Induced corneal penetrating wounds were sealed by application of single blood donor fibrin glue and human corneal lenticule obtained from SMILE in the treatment group. In the control group, 2 simple interrupted nylon 10-0 sutures were used for wound closure. Intraocular pressure (IOP) was set at 30 mmHg using the Centurion® Vision System and IOP was increased by increments of 5 mmHg until leakage is documented. Results: All porcine eyes in the control group showed no leakage immediately after sealing. One out of 10 eyes in the experimental group showed positive Seidel’s test after application of lenticule patch graft (odds ratio = 1.11 [0.904-1.336]). The mean leakage pressure for the suture group was significantly higher at 87.00 ± 4.83 mmHg compared to the lenticule group at 30.00 + 0.00 mmHg (p-value <0.001). Conclusion Human corneal lenticule from SMILE with single blood donor fibrin glue as cornel patch is less effective in sealing induced corneal penetrating wounds in cadaveric porcine eyes at IOP equal to or greater than 30 mmHg as compared to suturing using 2 simple interrupted nylon 10-0 sutures.
Fibrin Tissue Adhesive

No abstract available.
Fibrin Tissue Adhesive ; Fibrin ; Surgery, Oral

No abstract available.
Fibrin Tissue Adhesive* ; Fistula* ; Tissue Adhesives*

Objective: To compare the tensile strength of fibrin glue, 2-octyl cyanoacrylate, and liquid ocular bandage to conventional nylon 10-0 sutures in sealing central linear corneal lacerations. Methods: An experimental in-vitro study was performed on 74 porcine eyes. A 27-gauge needle connected to an infusion system with balanced salt solution was inserted into the anterior chamber and the bottle height was adjusted accordingly. Full-thickness central corneal lacerations were created using a 3.2 mm keratome knife for the initial incision and enlarged by a 5.2 mm knife. The wounds were sealed with fibrin glue (Tisseel®), 2-octyl cyanoacrylate (Dermabond®), liquid ocular bandage (OcuSeal™), and nylon 10-0 with 3 sutures. Tensile strength of the wounds was measured by recording the bottle height above the level of the porcine eyes before leakage was detected and this was converted to IOP values. One-way ANOVA and post hoc t-test were used to analyze the data. Results: Mean maximum IOP where leakage was resisted for the nylon 10-0 suture group was 52.37 ± 7.16 mm Hg. The mean maximum resisted IOP for the fibrin glue, 2-octyl cyanoacrylate, and liquid ocular bandage was 46.34 ± 12.64 mm Hg, 55.13 ± 10.46 mm Hg, and 56.99 ± 8.27 mm Hg respectively. There was no significant difference between the sutures and all of the adhesives groups (p=0.08, p=0.34, and p=0.08) and between 2-octyl cyanoacrylate and liquid ocular bandage (p=0.57). 2-Octyl cyanoacrylate and liquid ocular bandage demonstrated higher mean IOP as compared to the fibrin group (p = 0.024 and p = 0.007). Conclusion Fibrin glue, 2-octyl cyanoacrylate, and liquid ocular bandage were shown to be effective in sealing 5.2 mm linear corneal lacerations, with 2-octyl cyanoacrylate and liquid ocular bandage being superior to the fibrin glue.
Tissue Adhesives ; Tensile Strength ; Fibrin Tissue Adhesive

Endoscopic retrograde cholangiopancreatography has become a standard procedure for the diagnosis and treatment of pancreatobiliary disease. Like any invasive procedure, it carries a small, but significant rate of serious complications such as duodenal perforation. Primary surgical closure is the treatment of choice for the cases of duodenal perforation. However, there have been some case reports in which endoscopic metal clip closure of an iatrogenic duodenal perforation was successful. We experienced three cases of successful treatment of the iatrogenic duodenal perforation using endoscopic clipping and fibrin glue injections during a duodenoscope insertion.
Cholangiopancreatography, Endoscopic Retrograde ; Duodenoscopes ; Fibrin Tissue Adhesive

Uneventful duodenal perforation during endoscopic retrograde cholangiopancreatography (ERCP) is an uncommon but occasionally fatal complication. ERCP-related perforations may occur during sphincterotomy and improper manipulation of the equipment and scope. Traditionally, duodenal perforation has been treated with early surgical repair. Recently, nonoperative early endoscopic management techniques including clips or fibrin glue have been reported. In the present paper we review the literature pertaining to the treatment of perforations.
Cholangiopancreatography, Endoscopic Retrograde ; Fibrin Tissue Adhesive ; Stents