1.Polymorphism of Haptoglobin in Patients with Premature Rupture of Membrane.
Jin Kyung CHO ; Yeun Hee KIM ; In Yang PARK ; Jong Chul SHIN ; Mi Kyung OH ; Seon Joo PARK ; Nam Hoon KIM ; In Sook KIM
Yonsei Medical Journal 2009;50(1):132-136
PURPOSE: To investigate whether allelic polymorphism of haptoglobin (Hp) is associated with premature rupture of membrane (PROM), the Hp phenotypes of pregnant women with PROM were analyzed. PATIENTS AND METHODS: The Hp phenotypes of 221 pregnant Korean women (187 control and 34 PROM patients) were determined by benzidine/hydrogen peroxide staining, following native polyacrylamide gel electrophoresis of hemoglobin-mixed sera. The Hp allele frequencies were calculated from the data of Hp phenotypes, and overall association with PROM was evaluated using Pearson Chi-Square test. RESULTS: The polymorphic distribution of the patients cohort who underwent a normal delivery (control group) was similar to that of healthy Koreans. In contrast, however, patients with PROM showed significantly higher occurrence of the Hp 1-1 phenotype than control group (23.5% vs 8.0%). Hp 2-2 phenotype was lower in PROM cohort (38.2%) than in the control group (48.7%). The Hp1 allele frequency in PROM group was significantly higher than that in the control group (0.426 vs 0.297, p = 0.034) with odds ratio of 1.762 (95% CI: 1.038 - 2.991). CONCLUSION: These findings suggest that pregnant Korean women who possess Hp1 allele (expressed as Hp 1-1 phenotype) have higher incidence of PROM than women with Hp2 allele (expressed as Hp 2-2 phenotype). This is the first study that evaluated the significance of Hp polymorphism with respect to the development of PROM.
Adult
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Asian Continental Ancestry Group/*statistics & numerical data
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Female
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Fetal Membranes, Premature Rupture/*ethnology/*genetics
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Gene Frequency
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Genetic Predisposition to Disease/ethnology
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Haptoglobins/*genetics
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Humans
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Incidence
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Infant, Newborn
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Korea/epidemiology
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Phenotype
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*Polymorphism, Genetic
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Pregnancy