1.Fertility-sparing surgery in high-risk ovarian cancer.
Antonino DITTO ; Giorgio BOGANI ; Fabio MARTINELLI ; Francesco RASPAGLIESI
Journal of Gynecologic Oncology 2015;26(4):350-351
No abstract available.
Female
;
Fertility Preservation/*methods
;
Humans
;
Ovarian Neoplasms/*surgery
2.Are we ready for conservative treatment in ovarian cancer?.
Jesus UTRILLA-LAYNA ; Ignacio ZAPARDIEL
Journal of Gynecologic Oncology 2015;26(1):75-76
No abstract available.
Female
;
Fertility Preservation/*methods
;
Humans
;
Neoplasm Staging
;
Ovarian Neoplasms/*surgery
3.Fertility preservation for male adolescent cancer patients.
Long-Long FU ; Kai-Shu ZHANG ; Yi-Qun GU
National Journal of Andrology 2017;23(3):262-266
Fertility preservation is a hotspot of research in reproductive medicine, and that of male adolescent cancer patients is drawing even more attention from reproductive and oncologic clinicians. Both cancer and its treatment can decrease semen quality and even induce irreversible damage to fertility. Sperm cryopreservation is an effective method for fertility preservation. In the past few years, marked advances have been made in the cryopreservation, transplantation, and in vitro culture of testis tissue and stem spermatogonial cells. Although still experimental, these approaches may offer some options to those with no mature sperm in the testis. Unfortunately, very few people know and participate in the studies of fertility preservation and the utilization rate of cryopreserved sperm remains low. Therefor reproductive physicians and oncologists are required to make more efforts to search for effective fertility preservation methods for male adolescent cancer patients.
Adolescent
;
Cryopreservation
;
Fertility Preservation
;
methods
;
Humans
;
Male
;
Neoplasms
;
therapy
;
Semen Analysis
;
Semen Preservation
;
methods
;
Spermatogonia
;
Testis
;
cytology
4.Fertility preservation in pediatric and young adult female cancer patients.
Hashin KIM ; Hoon KIM ; Seung Yup KU
Annals of Pediatric Endocrinology & Metabolism 2018;23(2):70-74
As the 5-year survival rate increases up to 80% in pediatric cancer patients, the number of women patients with reduced gonadal function by chemotherapy and radiotherapy increases. The gonadal toxicity of pediatric patients varies highly according to the chemotherapeutic agent and the type of radiotherapy. Although American Society of Clinical Oncology published the guideline for fertility preservation, additional scientific and ethical concerns should be considered for clinical practice. In addition, only the experimental method can be applied for the prepubertal patients in contrast to the postpubertal patients. In this review, we will discuss some options for preserving fertility among women’s quality of life issues.
Drug Therapy
;
Female*
;
Fertility Preservation*
;
Fertility*
;
Gonads
;
Humans
;
Infertility, Female
;
Medical Oncology
;
Methods
;
Quality of Life
;
Radiotherapy
;
Survival Rate
;
Young Adult*
5.Fertility sparing surgery in patients with early stage epithelial ovarian cancer: implication of survival analysis and lymphadenectomy.
Journal of Gynecologic Oncology 2014;25(4):270-271
No abstract available.
Female
;
Fertility Preservation/*methods
;
Humans
;
Neoplasms, Glandular and Epithelial/*surgery
;
Ovarian Neoplasms/*surgery
;
Pregnancy
6.Risk and protection of fertility in male cancer patients.
Gan DONG ; Zi-Chao XIU ; Pei-Tao WANG ; Xin-Sheng WANG
National Journal of Andrology 2017;23(3):271-275
Gonad damage is one of the major complications of chemotherapy, radiotherapy or surgery in male cancer patients. For those who wish for childbearing after treatment, it is of great significance how to protect the reproductive function of the cancer patients. The main strategy for fertility protection is to optimize the treatment protocol, hormone therapy, antioxidant therapy, and the preservation of sperm and testicular tissue. This article presents an overview on the pathogenesis of gonadal damage induced by different treatments and protection of the reproductive function of the patient.
Fertility Preservation
;
methods
;
Humans
;
Infertility, Male
;
prevention & control
;
Male
;
Neoplasms
;
therapy
;
Risk
;
Spermatozoa
7.Testicular sperm cryopreservation for male fertility preservation.
Yan-Rong KUAI ; Zhan-Ju HE ; Xue-Yong CAI ; Sheng WAN ; Yi-Ming YUAN ; Jing PENG ; Lei ZHANG ; Qing XUE ; Jing SHANG ; Fei CHEN ; Hui-Yan JU ; Wen-Li ZUO ; Qin-Ping LIAO ; Yang XU
National Journal of Andrology 2012;18(3):231-234
OBJECTIVETo investigate the effectiveness of testicular sperm cryopreservation in male fertility preservation by evaluating the clinical outcome of ICSI cycles with frozen-thawed testicular sperm for azoospermia patients.
METHODSWe retrospectively analyzed 96 samples of cryopreserved testicular sperm obtained by testicular biopsy, vasovasostomy (V-V), vasoepididymostomy (V-E) , of which 55 were subjected to 60 ICSI cycles with frozen-thawed testicular sperm. We evaluated the rates of sperm recovery, fertilization, cleavage, transferable and good-quality embryos, clinical pregnancy, pregnancy outcome, and health of the newborns.
RESULTSAll the frozen testicular sperm samples were recovered successfully. The rates of fertilization, 2PN fertilization, cleavage, available embryos and good-quality embryos were 77.6, 69.4, 99.4, 84.5 and 40.8%, respectively. There were transferable embryos in all cycles. Fresh embryos were transferred in 52 of the 60 cycles, with the clinical pregnancy rate of 57.7% (30/52), including 19 singletons and 11 twins, and the rates of implantation and miscarriage were 38.7% (41/106) and 3.33% (1/30). Up to the present time, there have been 20 healthy newborns, including 12 boys and 8 girls, and another 13 ongoing pregnancies. No birth defects have been found so far.
CONCLUSIONDesirable clinical outcomes can be obtained from ICSI cycles with frozen-thawed testicular sperm, and testicular sperm cryopreservation is an effective method of fertility preservation for azoospermia males.
Adult ; Azoospermia ; therapy ; Cryopreservation ; Female ; Fertility Preservation ; methods ; Humans ; Male ; Pregnancy ; Pregnancy Outcome ; Retrospective Studies ; Semen Preservation ; methods ; Sperm Injections, Intracytoplasmic ; methods
8.Asian Society of Gynecologic Oncology International Workshop 2014.
Jeong Yeol PARK ; Hextan Yuen Sheung NGAN ; Won PARK ; Zeyi CAO ; Xiaohua WU ; Woong JU ; Hyun Hoon CHUNG ; Suk Joon CHANG ; Sang Yoon PARK ; Sang Young RYU ; Jae Hoon KIM ; Chi Heum CHO ; Keun Ho LEE ; Jeong Won LEE ; Suresh KUMARASAMY ; Jae Weon KIM ; Sarikapan WILAILAK ; Byoung Gie KIM ; Dae Yeon KIM ; Ikuo KONISHI ; Jae Kwan LEE ; Kung Liahng WANG ; Joo Hyun NAM
Journal of Gynecologic Oncology 2015;26(1):68-74
The Asian Society of Gynecologic Oncology International Workshop 2014 on gynecologic oncology was held in Asan Medical Center, Seoul, Korea on the 23rd to 24th August 2014. A total of 179 participants from 17 countries participated in the workshop, and the up-to-date findings on the management of gynecologic cancers were presented and discussed. This meeting focused on the new trends in the management of cervical cancer, fertility-sparing management of gynecologic cancers, surgical management of gynecologic cancers, and recent advances in translational research on gynecologic cancers.
Female
;
Fertility Preservation/methods
;
Genital Neoplasms, Female/*therapy
;
Humans
;
Ovarian Neoplasms/therapy
;
Translational Medical Research/methods
;
Uterine Cervical Neoplasms/therapy
9.Successful onco-testicular sperm extraction from a testicular cancer patient with a single testis and azoospermia.
Shinnosuke KURODA ; Takuya KONDO ; Kohei MORI ; Kengo YASUDA ; Takuo ASAI ; Hiroyuki SANJO ; Hiroyuki YAKANAKA ; Teppei TAKESHIMA ; Takashi KAWAHARA ; Yoshitake KATO ; Yasuhide MIYOSHI ; Hiroji UEMURA ; Akira IWASAKI ; Yasushi YUMURA
Clinical and Experimental Reproductive Medicine 2018;45(1):44-47
Onco-testicular sperm extraction is used to preserve fertility in patients with bilateral testicular tumors and azoospermia. We report the case of a testicular tumor in the solitary testis of a patient who had previously undergone successful contralateral orchiectomy and whose sperm was preserved by onco-testicular sperm extraction. A 35-year-old patient presented with swelling of his right scrotum that had lasted for 1 month. His medical history included a contralateral orchiectomy during childhood. Ultrasonography revealed a mosaic echoic area in his scrotum, suggesting a testicular tumor. The lesion was palpated within the normal testicular tissue along its edge and semen analysis showed azoospermia. Radical inguinal orchiectomy and onco-testicular sperm extraction were performed simultaneously. Motile spermatozoa were extracted from normal seminiferous tubules under microscopy and were frozen. Eventual intracytoplasmic sperm injection using the frozen spermatozoa is planned. Onco-testicular sperm extraction is an important fertility preservation method in patients with bilateral testicular tumors or a history of a previous contralateral orchiectomy.
Adult
;
Azoospermia*
;
Fertility
;
Fertility Preservation
;
Humans
;
Infertility, Male
;
Male
;
Methods
;
Microscopy
;
Orchiectomy
;
Scrotum
;
Semen Analysis
;
Seminiferous Tubules
;
Sperm Injections, Intracytoplasmic
;
Sperm Retrieval
;
Spermatozoa*
;
Testicular Neoplasms*
;
Testis*
;
Ultrasonography
10.Fertility-preserving treatment and pregnancy outcomes in the early stage of endometrial carcinoma.
Xiao-mei TONG ; Xiao-na LIN ; Hong-fei JIANG ; Ling-ying JIANG ; Song-ying ZHANG ; Feng-bing LIANG
Chinese Medical Journal 2013;126(15):2965-2971
OBJECTIVEThis study aimed to review the available literature on fertility-preserving treatment and pregnancy outcomes in patients with early-stage endometrial carcinoma who desired to preserve their fertility.
DATA SOURCESThe PubMed database (1992-2012) was searched for the words "conservative "OR" fertility sparing "OR" fertility preserving" AND "endometrial neoplasms" (MeSH). All relevant articles in English and the relevant references were collected.
STUDY SELECTIONData from published articles about fertility-preserving treatment of endometrial cancer, including the response and recurrence rate of conservative treatment, strategies of infertility treatment, pregnancy, and obstetric outcomes, were selected. Data were mainly extracted from 41 studies, which are listed in the reference section of this review.
RESULTSHormone therapy was the most common method used for early-stage endometrial carcinoma in patients who wished to preserve fertility. Sixty percent of the patients became pregnant after remission of the carcinoma. The percentage of patients who conceived in the assisted reproductive technology group was higher than that of the natural pregnancy group (80.0% vs. 43.2%, P < 0.01). A higher rate of preterm labor and multiple pregnancies was observed in the assisted reproductive technology group than that in the natural pregnancy group. The majority of pregnancies (71.4%) in the assisted reproductive technology group were achieved by in vitro fertilization-embryo transfer. The clinical pregnancy rate of transfer cycles in patients with endometrial carcinoma was 34.1%.
CONCLUSIONSAssisted reproductive technology is a good option in well-selected patients with early-stage endometrial carcinoma who have completed conservative treatment. In vitro fertilization-embryo transfer offers an opportunity to achieve an immediate pregnancy.
Endometrial Neoplasms ; therapy ; Female ; Fertility Preservation ; methods ; Humans ; Neoplasm Staging ; Pregnancy ; Pregnancy Complications, Neoplastic ; Pregnancy Outcome ; Reproductive Techniques, Assisted