1.Ferroptosis as an important driver of lupus.
Chao MAO ; Guang LEI ; Li ZHUANG ; Boyi GAN
Protein & Cell 2022;13(5):313-315
2.HPCAL1 is a novel driver of autophagy-dependent ferroptosis.
Liwen WANG ; Qin LI ; Huimei LIU ; Lanfang LI
Journal of Zhejiang University. Science. B 2023;24(11):1053-1056
自噬是细胞内一种高度保守的生理过程,可通过溶酶体系统降解过量或受损的细胞器、有毒的蛋白聚集体和病原体等。最新研究表明,海马钙素样1(HPCAL1)可作为特异性自噬受体和铁死亡的正调节因子。HPCAL1可选择性降解钙粘素2(CDH2),加速脂质过氧化,促进癌细胞铁死亡。iHPCAL1是抑制HPCAL1的小分子化合物,可抑制Erastin诱导的肿瘤细胞铁死亡。此外,它还可以抑制铁死亡诱导的急性胰腺炎。本文通过对HPCAL1在铁死亡中的具体作用机制进行概述,为HPCAL1作为铁死亡相关疾病的潜在治疗靶点提供新思路和理论依据。
Ferroptosis
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Cell Line, Tumor
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Autophagy
4.Ferroptosis, radiotherapy, and combination therapeutic strategies.
Guang LEI ; Chao MAO ; Yuelong YAN ; Li ZHUANG ; Boyi GAN
Protein & Cell 2021;12(11):836-857
Ferroptosis, an iron-dependent form of regulated cell death driven by peroxidative damages of polyunsaturated-fatty-acid-containing phospholipids in cellular membranes, has recently been revealed to play an important role in radiotherapy-induced cell death and tumor suppression, and to mediate the synergy between radiotherapy and immunotherapy. In this review, we summarize known as well as putative mechanisms underlying the crosstalk between radiotherapy and ferroptosis, discuss the interactions between ferroptosis and other forms of regulated cell death induced by radiotherapy, and explore combination therapeutic strategies targeting ferroptosis in radiotherapy and immunotherapy. This review will provide important frameworks for future investigations of ferroptosis in cancer therapy.
Ferroptosis/immunology*
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Humans
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Immunotherapy
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Neoplasms/therapy*
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Radiotherapy
5.Ferroptosis:Mechanism and Role in Malignant Tumors.
Xin-Feng WANG ; Yu-Xin YAO ; Pan WANG
Acta Academiae Medicinae Sinicae 2023;45(4):647-654
Ferroptosis is a new type of programmed cell death different from other cell death pathways such as apoptosis,autophagy,necrosis,and pyroptosis in terms of initiation,mechanisms,and molecular characteristics.As the accumulation of phospholipid hydroperoxides is the hallmark of ferroptosis,the balance between oxidative damage and antioxidant defense is critical to the regulatory mechanism of ferroptosis.In cancer,the upregulation of antioxidant defense pathways can inhibit ferroptosis,thereby promoting cancer cells to survive the oxidative stress and develop drug resistance.This review systematically introduces the main features and regulatory mechanisms of ferroptosis.In addition,we summarize the role of ferroptosis in the progression and drug resistance of malignant tumors,providing novel implications for further research on the pathogenesis of malignant tumors and discovery of new targets for anti-cancer therapy.
Humans
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Ferroptosis
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Antioxidants
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Apoptosis
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Neoplasms
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Autophagy
7.Targeting ferroptosis and ferritinophagy: new targets for cardiovascular diseases.
Yi LUAN ; Yang YANG ; Ying LUAN ; Hui LIU ; Han XING ; Jinyan PEI ; Hengdao LIU ; Bo QIN ; Kaidi REN
Journal of Zhejiang University. Science. B 2024;25(1):1-22
Cardiovascular diseases (CVDs) are a leading factor driving mortality worldwide. Iron, an essential trace mineral, is important in numerous biological processes, and its role in CVDs has raised broad discussion for decades. Iron-mediated cell death, namely ferroptosis, has attracted much attention due to its critical role in cardiomyocyte damage and CVDs. Furthermore, ferritinophagy is the upstream mechanism that induces ferroptosis, and is closely related to CVDs. This review aims to delineate the processes and mechanisms of ferroptosis and ferritinophagy, and the regulatory pathways and molecular targets involved in ferritinophagy, and to determine their roles in CVDs. Furthermore, we discuss the possibility of targeting ferritinophagy-induced ferroptosis modulators for treating CVDs. Collectively, this review offers some new insights into the pathology of CVDs and identifies possible therapeutic targets.
Humans
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Cardiovascular Diseases
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Ferroptosis
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Iron
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Trace Elements
9.Ferroptosis in respiratory diseases.
Hai-Xia CHEN ; Yan-Ping WU ; Wen LI ; Hua-Hao SHEN ; Zhi-Hua CHEN
Acta Physiologica Sinica 2020;72(5):575-585
Ferroptosis is a novel form of regulated cell death which is dependent on iron and reactive oxygen species (ROS) and associated with the accumulation of lipid peroxides. It is obviously different from other cell death types in terms of morphology, biochemistry, genetics, etc. Also, it is related to the production of iron catalyzed lipid peroxides which is triggered by non-enzymatic or enzymatic reactions. Ferroptosis has been proved to be involved in hematological diseases, cardio-cerebrovascular diseases, liver and kidney diseases. This paper will review the definition, mechanism, inducers of ferroptosis, as well as the function of ferroptosis in respiratory system. We expect to present a new concept for respiratory research and suggest potential targets for clinical prevention and treatment of respiratory diseases.
Cell Death
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Ferroptosis
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Humans
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Iron
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Reactive Oxygen Species
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Respiration Disorders
10.The role of ferroptosis in chronic diseases.
Junyi CHEN ; Xiang YANG ; Xuexian FANG ; Fudi WANG ; Junxia MIN
Journal of Zhejiang University. Medical sciences 2020;49(1):44-57
Recently, ferroptosis, an iron-dependent novel type of cell death, has been characterized as an excessive accumulation of lipid peroxides and reactive oxygen species. Emerging studies demonstrate that ferroptosis not only plays an important role in the pathogenesis and progression of chronic diseases, but also functions differently in the different disease context. Notably, it is shown that activation of ferroptosis could potently inhibit tumor growth and increase sensitivity to chemotherapy and immunotherapy in various cancer settings. As a result, the development of more efficacious ferroptosis agonists remains the mainstay of ferroptosis-targeting strategy for cancer therapeutics. By contrast, in non-cancerous chronic diseases, including cardiovascular & cerebrovascular diseases and neurodegenerative diseases, ferroptosis functions as a risk factor to promote these diseases progression through triggering or accelerating tissue injury. As a matter of fact, blocking ferroptosis has been demonstrated to effectively prevent ischemia-reperfusion heart disease in preclinical animal models. Therefore, it is a promising field to develope potent ferroptosis inhibitors for preventing and treating cardiovascular & cerebrovascular diseases and neurodegenerative diseases. In this article, we summarize the most recent progress on ferroptosis in chronic diseases, and draw attention to the possible clinical impact of this recently emerged ferroptosis modalities.
Animals
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Chronic Disease
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Ferroptosis
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physiology
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Iron
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metabolism
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Reactive Oxygen Species