AIMTo isolate IL-6R antagonists from the cultured broth of the strain Torulomyces ovatus.

METHODSVarious column chromatographyes were used to separate and purify the compounds with IL-6R antagonist activity. The spectral data and physic-chemical properties were measured for structure identification.

RESULTSOne compound namely 2520 was isolated from the cultured broth of Torulomyces ovatus.

CONCLUSION2520A is a known compound (ferrichrome). It is first reported about its antagonistic activity of IL-6R and identification of iron atom in its structure.

Anti-Bacterial Agents ; chemistry ; isolation & purification ; pharmacology ; Antineoplastic Agents ; chemistry ; isolation & purification ; pharmacology ; Bacillus subtilis ; drug effects ; Cell Line, Tumor ; Cell Survival ; drug effects ; Fermentation ; Ferric Compounds ; chemistry ; isolation & purification ; pharmacology ; Ferrichrome ; chemistry ; isolation & purification ; pharmacology ; Humans ; Mitosporic Fungi ; chemistry ; Molecular Structure ; Peptides, Cyclic ; chemistry ; isolation & purification ; pharmacology ; Receptors, Interleukin-6 ; antagonists & inhibitors