Objective　To explore the relationship between the levels of serum lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) and angiopoietin-like protein 8 (ANGPTL8) and the degree of neurological deficit and prognosis of patients with acute watershed cerebral infarction.Methods　From June 2018 to July 2021,105 patients with acute watershed cerebral infarction accepted by our hospital were enrolled as the research group,the NIHSS scale was used to evaluate the degree of neurological deficit,and the patients were divided into mild neurological deficit group and moderate-severe neurological deficit group;the modified Rankin scale was used to evaluate the prognosis of the patients,and they were grouped into a good prognosis group and a poor prognosis group;another 100 healthy subjects were enrolled as the control group,the serum levels of LOX-1 and ANGPTL8 of subjects in each group were detected,and the differences between groups were compared.Receiver operating characteristic (ROC) curve was drawn to analyze the evaluation value of serum LOX-1 and ANGPTL8 levels for the degree of neurological deficit and prognosis in patients with acute watershed cerebral infarction.Results　The levels of serum LOX-1 and ANGPTL8 in the study group were obviously higher than those in the control group,the levels of serum LOX-1 and ANGPTL8 in the moderate to severe neurological deficit group were obviously higher than those in the mild neurological deficit group,and the levels of serum LOX-1 and ANGPTL8 in the poor prognosis group were also obviously higher than those in the good prognosis group (P<0.05).The area under the curve (AUC) of serum LOX-1 and ANGPTL8 combined to assess moderate to severe neurological deficit in patients with acute watershed cerebral infarction was 0.894,which was greater than that of LOX-1 (0.763) and ANGPTL8 (0.852) alone (P<0.05);the AUC of the two combined assessment of acute watershed cerebral infarction patients with poor prognosis was 0.932,which was greater than that of LOX-1 and ANGPTL8 alone (P<0.05).Conclusion　Serum LOX-1 and ANGPTL8 levels are up-regulated in patients with acute watershed cerebral infarction,and the combination of the two has a higher efficacy in evaluating the degree of neurological deficit and prognosis of patients.