1.The comparison of optic disc parameters and the thickness of circumpapillary retinal nerve fiber layer between acute Vogt-Koyanagi-Harada syndrome and acute central serous chorioretinopathy
Yanhua PANG ; Lijiao NIE ; Zhi TAN ; Fengyan ZHOU ; Xuehui YUAN ; Qiurong LYU ; Guiling ZHAO
Chinese Journal of Ocular Fundus Diseases 2019;35(4):369-373
Objective To compare the differences of optic nerve head (ONH) parameters and the thickness of circumpapillary retinal nerve fiber layer (CP-RNFL) between acute Vogt-Koyanagi-Harada syndrome (VKH) and acute central serous chorioretinopathy (CSC) patients.Methods Retrospective clinical case control analysis.This study included 38 eyes of 20 acute VKH patients (VKH group) and 37 eyes of 37 acute CSC patients (CSC group).Seventy five eyes of 57 normal healthy subjects,matching patients with age and gender,were collected as control group.The disc RPE angle,the thickness of average CP-RNFL,the nasal,superior,temporal and inferior quadrant CP-RNFL thickness,and ONH parameters including optic disc area,cup area,rim area,C/D area ratio,linear CD ratio (CDR),vertical CDR were measured by 3D-OCT.Analysis of variance was performed for comparison among three groups.Minimum significant difference t test was performed for comparison between two groups.Results The differences of ONH parameters between VKH group and CSC group:29 eyes of VKH group appeared retinal detachment next to disc,only 12 eyes appeared in CSC group.Twenty one eyes of VKH group appeared optic disc hyperemia while none in CSC group.The three groups' disc RPE angles were (138.62± 11.96)°,(154.09±5.85)° and (153.41 ±5.77)°.VKH group were significantly smaller than CSC group (t=-2.05,P=0.00) and control group (t=-1.68,P=0.00),while there was no significant difference between CSC group and control group (t=-1.88,P=0.72).The optic cup area and rim area were significantly bigger in VKH group than in CSC group (t=4.61,2.71;P=0.00,0.01),and the thickness of mean CP-RNFL,all quadrants of CP-RNFL were significantly thicker in VKH group than in CSC group (t=6.25,4.40,3.53,5.48,2.69;P=0.00,0.00,0.00,0.00,0.01).Conclusion Compared with the acute CSC,VKH patients are likely to appear retinal detachment next to disc,their disc RPE angles are smaller,their optic cup area and rim area are bigger,and their CP-RNFL thickness are thicker.
2. Effect of 1q21 amplification on bortezomib therapeutic response and prognosis of newly diagnosed multiple myeloma patients
Xuelian LIU ; Peiyu YANG ; Xiaoyuan YU ; Jingcheng CHEN ; Xiaoliang LIU ; Jing BAI ; Yingmin LIU ; Hua HE ; Jingnan SUN ; Hongqiong FAN ; Chen ZHANG ; Ye ZHANG ; Keju SU ; Chunshui LIU ; Yehui TAN ; Sujun GAO ; Wei LI ; Fengyan JIN
Chinese Journal of Hematology 2018;39(5):408-413
Objective:
To investigate the effect of 1q21 amplification (1q) on the therapeutic response and prognosis of bortezomib(Btz) in the treatment of newly diagnosed multiple myeloma (MM) patients.
Methods:
A total of 180 newly diagnosed MM were included for analyses of clinical characteristics, cytogenetics, objective response rate (ORR), progression-free survival (PFS) and overall survival (OS), retrospectively. Gene expression profiling (GEP) was analyzed using publicly available R2 platform.
Results:
① In 180 patients, 1q was found in 51.1% cases. Of them, 174 patients had complete follow-up data, including 88 cases with 1q and 86 without 1q (non-1q). ②Incidence of 1q was positively associated with percentage of IGH rearrangement (72.2%,
3.Clinical observation of camrelizumab combined with pemetrexed and nedaplatin in the treatment of EGFR/ALK wild-type advanced non-squamous non-small cell lung cancer
Fengyan TAN ; Yiding TANG ; Long MENG ; Jie SONG ; Feng QIU ; Rui LONG
China Pharmacy 2024;35(16):2013-2017
OBJECTIVE To observe the efficacy and safety of camrelizumab combined with pemetrexed and nedaplatin in the treatment of epidermal growth factor receptor (EGFR) and anaplastic lymphoma kinase (ALK) wild-type advanced non-squamous non-small cell lung cancer (NSCLC). METHODS The data of 92 patients with EGFR/ALK wild-type advanced non-squamous NSCLC patients who visited the First Affiliated Hospital of Chongqing Medical University from August 2021 to May 2023 were collected and divided into nedaplatin group (46 cases) and carboplatin group (46 cases) based on different treatment regimens. Nedaplatin group was given camrelizumab for injection+nedaplatin for injection+pemetrexed disodium for injection; carboplatin group was given camrelizumab for injection+carboplatin injection+pemetrexed disodium for injection. Both groups received treatment with 21 days as one cycle, and all patients would be treated at least two cycles. The recent efficacy and the incidence of adverse drug reactions were observed in two groups, and the factors affecting progression-free survival (PFS) of patients were analyzed. RESULTS There was no statistically significant difference in the objective response rate, disease control rate, median PFS, and the incidence of grade 3-5 treatment-related adverse event (TRAE) between the two groups (P>0.05). While the incidence of grade 1-2 renal and urinary system TREA, palpitations and pericardial effusion in nedaplatin group were significantly lower than carboplatin group, the incidence of nausea, vomiting and decreased appetite were significantly higher than carboplatin group (P<0.05). The patient’s gender, age, smoking history, Eastern United States Cancer Collaboration score, and TNM staging were not significant factors affecting patient’s PFS (P>0.05). CONCLUSIONS Camrelizumab combined with pemetrexed and nedaplatin has significant efficacy in the treatment of EGFR/ALK wild-type advanced non-squamous NSCLC, with good safety.