Objective: : Cranial base chordomas are rare, but their treatment is challenging. Tumor recurrence is still common despite improvements in microsurgical techniques and postoperative radiotherapy. We retrospectively analyzed the course of treatment, overall survival, and recurrence/progression of chordomas over the past 10 years. Methods: : We retrospectively reviewed 50 patients who underwent surgery at Tianjin Huanhu Hospital between 2010 and 2020 and were pathologically diagnosed with chordomas. Tumor resection was performed within the maximum safe range in all patients; the extent of resection was evaluated by imaging; and the incidence of complications, recurrence or progression, and overall survival were assessed. Results: : Fifty patients were divided into the low-risk group (LRG) and high-risk group (HRG) based on the cranial chordoma grading system (CCGS). The Karnofsky Performance Scale scores and gross total resection rate of the LRG were significantly higher than those of the HRG (p<0.05). The incidence of complications and mortality in the LRG were lower than those of HRG. The analysis of cumulative survival and cumulative recurrence free survival/progression free survival (RFS/PFS) showed no statistical differences in the extent of resection for survival, recurrence, or progression. Univariate and multivariate analyses showed that Ki-67 was significantly associated with tumor recurrence and was an independent hazard factor (p=0.02). Conclusion : The CCGS can help neurosurgeons anticipate surgical outcomes. Pathological results are important in evaluating the possibility of tumor recurrence, and postoperative radiotherapy improves overall survival and RFS/PFS.

Objective To explore clinical efficacy of swallowing function training in reducing lung infection in craniocerebral injury patients with tracheotomy.Methods A total of 124 craniocerebral injury patients in the hospital were randomized into experimental group and control group, the control group received conventional treatment, while the experimental group took swallowing function training based on the control group, secretion samples of pulmonary infection patients were collected for bacterial culture, identification and susceptibility test, and swallowing, lung infection rate and catheter indwelling time were compared.Results There were 223 strains of pathogens detected in 43 patients with lung infection after culture and isolation, including 65 strains(29.15%) of gram-positive bacteria, 148(66.37%) of gram-negative bacteria, and 18 (8.07%) of fungus.The resistance rates of staphylococcus aureus to penicillin G, ampicillin were more than 87%, and was sensitive to vancomycin, rifampin, and clindamycin.Enterococcus faecalis was resistant to ciprofloxacin, and penicillin G.Staphylococcus epidermidis cocci was sensitive to vancomycin, rifampin, clindamycin.Acinetobacter baumannii, pseudomonas aeruginosa, Klebsiella pneumoniae had higher resistance to ceftazidime, cefotaxime, and ofloxacin, whereas was sensitive to imipenem, and meropenem.And resistance rates of Acinetobacter baumannii and Klebsiella pneumoniae to piperacillin/tazobactam, and cefoperazone/sulbactam were less than 30%;Pseudomonas aeruginosa had wide range of drug resistance, but was sensitive to imipenem, and meropenem only.After treatment, excellent rate in the experimental group was significantly better than the treatment before and the control group (P<0.05).Experimental group had less lung infection and less catheter indwelling time than the control group(P<0.05).Conclusion Swallowing training for craniocerebral injury patients with tracheotomy can effectively reduce lung infection, shorten catheter indwelling time, and improve the prognosis.

Objective To explore clinical efficacy of swallowing function training in reducing lung infection in craniocerebral injury patients with tracheotomy.Methods A total of 124 craniocerebral injury patients in the hospital were randomized into experimental group and control group, the control group received conventional treatment, while the experimental group took swallowing function training based on the control group, secretion samples of pulmonary infection patients were collected for bacterial culture, identification and susceptibility test, and swallowing, lung infection rate and catheter indwelling time were compared.Results There were 223 strains of pathogens detected in 43 patients with lung infection after culture and isolation, including 65 strains(29.15%) of gram-positive bacteria, 148(66.37%) of gram-negative bacteria, and 18 (8.07%) of fungus.The resistance rates of staphylococcus aureus to penicillin G, ampicillin were more than 87%, and was sensitive to vancomycin, rifampin, and clindamycin.Enterococcus faecalis was resistant to ciprofloxacin, and penicillin G.Staphylococcus epidermidis cocci was sensitive to vancomycin, rifampin, clindamycin.Acinetobacter baumannii, pseudomonas aeruginosa, Klebsiella pneumoniae had higher resistance to ceftazidime, cefotaxime, and ofloxacin, whereas was sensitive to imipenem, and meropenem.And resistance rates of Acinetobacter baumannii and Klebsiella pneumoniae to piperacillin/tazobactam, and cefoperazone/sulbactam were less than 30%;Pseudomonas aeruginosa had wide range of drug resistance, but was sensitive to imipenem, and meropenem only.After treatment, excellent rate in the experimental group was significantly better than the treatment before and the control group (P<0.05).Experimental group had less lung infection and less catheter indwelling time than the control group(P<0.05).Conclusion Swallowing training for craniocerebral injury patients with tracheotomy can effectively reduce lung infection, shorten catheter indwelling time, and improve the prognosis.

Humans ; Data Warehousing ; East Asian People ; Intracranial Hemorrhages/diagnostic imaging* ; Asian People ; Cerebral Hemorrhage/diagnostic imaging*