1. Analysis on the heritability of diabetes, based on data from the Chinese adult twins
Fengxia GAN ; Wenjing GAO ; Jun LYU ; Canqing YU ; Shengfeng WANG ; Zengchang PANG ; Liming CONG ; Zhong DONG ; Fan WU ; Hua WANG ; Xianping WU ; Guohong JIANG ; Xiaojie WANG ; Binyou WANG ; Zheng CHANG ; Ralf KUJA-HALKOLA ; Weihua CAO ; Liming LI
Chinese Journal of Epidemiology 2019;40(4):389-393
Objective:
To analyze the heritability of diabetes among the Chinese twin adults.
Methods:
A total of 10 253 same-sex twin pairs aged 25 years and older, were selected from the Chinese National Twin Registry (CNTR) program. Heritability of diabetes was calculated by using the structural equation model.
Results:
After adjusted for age and gender, the overall heritability rates of diabetes were 0.41 (0.15-0.75), 0.83 (0.72-0.91) and 0.34 (0.04-0.73) in the <45 and ≥45 years twin pairs, respectively. After adjusted for age, rates of heritability appeared as 0.37 (0.05-0.78) and 0.88 (0.79-0.94) in men and women, respectively.
Conclusions
Diabetes is affected by both genetic and environmental factors. The genetic effect of diabetes seemed stronger on female than that on male twins but was dying down along with ageing.
Result Analysis
Print
Save
E-mail