Objective To investigate the clinical significance of serum ferritin level(SF),serum iron(SI) level in patients with chronic hepatitic B.Methods SF was measured by radioimmunoassay,serum iron was measured through atomic absorption spectrometry.Results Chronic HBV infectors mostly had high level of SF and SI,with severity of illness state increasing,especially in the group of severe hepatitis.The levels of SF and SI correlated with HBV duplication to a certain extent and specifically SF and SI increased with the increase of virus duplication.However,it had no statistical significance.Among the sufferers of hepatocirrhosis,numerical values of SF and SI turned to increase with the rank of Child-Pugh(A,B and C) and SF had the correlation with LN(the index of hepatic fibrosis).Patients of hepatocirrhosis with a high SF level had higher frequency of complications occurrence and reoccurrence,the clinical post-cure effects were worse.Conclusion SF and SI can be reference index in forecasting the degree of disease state,hepatic fibrosis and clinical post-cure.

0.05). The positive rate of HBeAg in genotype C(69.7%) was significantly higher than that in genotype B(42%) (P

Objective To investigate the relationship between hepatitis B virus (HBV) genotype and liver function. Methods The method of microboard nucleate molecular hybridization was employed to detect the genotype in 93 HBV patients of different clinical types and the function of liver. Results Among the 93 HBV patients of different clinical types, there were 24 cases of genotype B (25.81%), 59 cases of genotype C (63.44%), 5 cases of genotype D (5.38%), and 5 cases of mixed type (3 cases of B/D, 2 cases of C/D, 5.38%). Therefore, genotype C took up the largest proportion, followed by genotype B, and then D and mixed genotypes, but there was no genotype A, E or F. The detection rate of genotype C increased according to the sequence of chronic hepatitis B, subacute severe hepatitis and hepatocirrhosis while the detection rate of genotype B decreased gradually. However, the detection rate of genotype C in hepatocellar carcinoma did not rise correspondingly. The levels of ALT, AST and TBIL of genotype C were higher than those of genotype B, but the level of ALB in genotype C was lower than that of genotype B. None of the differences had significance. Conclusion Most of HBV genotypes in Xi'an were C, some of them were B, D and mixed genotypes, but no genotype A, E or F was detected. Except hepatocellar carcinoma, the detection rate of genotype C rose according to the severity of clinical type.

Objective:To analyze one case of delayed diarrhea caused by irinotecan. Methods:The pathogeny, mechanism, ge-netics and treatment of the case were analyzed. Results:Delayed diarrhea was the dose-limited toxicity of irinotecan, which was related with the cytotoxicity of the active metabolite 7-ethyl-10-hydroxycamptothecin (SN-38). Genetic polymorphism was one of important risk factors, especially UGT1A1 polymorphisms could be used as a predictor for the diarrhea. The pharmacotherapy of the diarrhea was ef-fective and rational, and the clinical pharmacist provided rational pharmaceutical care for the patient. Conclusion:It is very important to enhance pharmaceutical care for the patients treated with irinotecan.