Bronchial asthma is a heterogeneous disease, and dust mite is the main allergen that causes typeⅠallergic reaction.Allergic reactions and inflammation reactions caused by dust mite allergenic proteins and allergenic components play a crucial role in the occurrence and development of asthma.Furthermore, nitric oxide and its derivatives produced by inflammatory cytokines in airway epithelium play a key role in inducing asthma.This paper reviews the effects of dust mite allergenic proteins, allergenic components and exhaled nitric oxide on asthma in recent years.

Objective:To evaluate the efficacy of 1-year subcutaneous immunotherapy (SCIT) with dust mites in polysensitized allergic rhinitis (AR) patients and to analyze the serological markers associated with clinical response.Methods:A retrospective analysis of data from 69 polysensitized AR patients who completed 1-year SCIT with dust mites from Oct 2020 to Mar 2022 in Shandong Provincial ENT Hospital was conducted. The median patient age was 21 years, including 41 males and 28 females. The changes in symptoms and serum IgE, IgG4 assessed before and after treatment were evaluated. The differences in serological markers between effective and ineffective groups were analyzed. Multivariate regression analysis was used to investigate the predictors of clinical response. SPSS 22.0 software was used for data processing.Results:After immunotherapy, there was a significant reduction in symptom scores and a substantial improvement in the quality of life of polysensitized AR patients (all P<0.001). Dust mite specific IgG4 (sIgG4) significantly increased and dust mite specific IgE (sIgE)/sIgG4 significantly decreased (all P<0.05). sIgE, total IgE (tIgE), sIgE/tIgE and sIgE/sIgG4 were significantly lower in ineffective group than those in effective group (all P<0.05). The clinical response of SCIT related only to dust mite sIgE ( r=0.29, P=0.036), and sIgE≥53.86 kU/L had the best sensitivity (77.78%) and specificity (57.89%) to predict effective SCIT in polysensitized AR patients. Conclusions:One-year dust mite SCIT is effective for polysensitized AR patients. Pre-treatment serum dust mite sIgE≥53.86 kU/L may play a role in predicting clinical response of dust mite SCIT in polysensitized AR patients.

Objective:To analyze the demographic and clinical characteristics of elderly inpatients with osteoporotic femoral neck fractures(OFNF).Methods:Clinical data of 1 227 patients with OFNF treated at the department of orthopedics of Beijing Hospital from January 2010 to December 2019 were analyzed retrospectively, including 377 male and 850 female patients.Ten-year trends in the OFNF constituent ratio, patient age, average length of stay and hospitalization expenses were examined, and differences in demographic and clinical characteristics between different genders were analyzed.Results:From 2010 to 2017, the constituent ratio of OFNF patients increased each year, and the number of OFNF patients decreased slightly in 2018 and 2019.The age of onset in both male and female patients was the highest at the ages of 80-89(46.8% or 574/1 227). In the distribution of educational level, people with no education made up the highest proportion(36.7% or 450/1 227). The seasonal distribution of the disease was the highest in autumn(27.8% or 341/1 227). The constituent ratio of urban areas was higher than that of rural areas(54.6% or 670/1 227 vs.45.4% or 557/1 227). In the distribution of fracture types, the constituent ratio of 31-B2 fractures was the highest in both male and female patients.Of the causes of injury, the constituent ratio of falls and indoor activities was the highest.Hypertension, spinal degenerative diseases and knee and hip osteoarthritis ranked in the top three of concomitant diseases.The constituent ratio of previous fractures in females was significantly higher than that in males.In the past ten years, the average hospitalization length of OFNF patients showed a downward trend, and the change in average hospitalization cost showed abrupt fluctuations.From 2009 to 2016, the hospitalization cost showed an upward trend, with the highest in 2016, and then decreased year by year. Conclusions:In the past ten years, the number and constituent ratio of OFNF patients increased steadily in the first eight years, but decreased slightly or reached a plateau in the past two years.The education level, history of bone fractures, hypertension, spinal degenerative diseases and knee and hip osteoarthritis of OFNF patients were correlated with sex, while age distribution, seasonal distribution, urban and rural distribution, cause of injury, fracture classification and other concomitant diseases were not correlated with sex.In the past ten years, the average hospitalization length of OFNF patients trended downward, the average hospitalization cost showed an upward trend from 2009 to 2016, and decreased year by year after 2016.The medical policy reform in 2016 played a significant role in controlling medical expenses.