OBJECTIVE:To investigate the effects of intra-articular injection of tranexamic acid on joint swelling,pain and recovery of joint function in patients with simple meniscus injury. METHODS:A total of 62 patients with simple meniscus injury receiving arthroscopic surgery of the knee in orthopedics department of Chongqing people's hospital during Oct. 2016-Apr. 2017 were selected and divided into control group and observation group according to random table,with 31 cases in each group. Both groups received meniscus excision or trimming under knee arthroscopy. Control group was given intra-articular injection of 0.9%Sodium chloride injection 10 mL after wound suture. Observation group was given intra-articular injection of Tranexamic acid for injection 2.0 g added into 0.9% Sodium chloride injection 10 mL after wound suture. The drainage tube was not placed in all the patients,The tourniquet was loosened after the pressurized dressing of wound. Circumferential diameter of the knee and VAS scores of 2 groups were observed before surgery,1,3,5 and 7 d after surgery. Lysholm scores were observed before and one month after surgery. The occurrence of ADR was recorded. RESULTS:There was no statistical significance in circumferential diameter of the knee,VAS score or Lysholm score between 2 groups before surgery(P>0.05). 1,3,5 and 7 d after surgery,circumferential diameter of the knee in 2 groups was significantly bigger than before surgery,but the observation group was significantly smaller than the control group 1,3 d after surgery,with statistical significance(P<0.05). There was no statistical significance in circumferential diameter of the knee between 2 groups 5 and 7 d after surgery(P>0.05). VAS score of observation group 1,3 d after surgery and control group 1,3 and 5 d after surgery were significantly higher than before surgery,but the observation group was significantly lower than the control group 1,3,5 d after surgery,with statistical significance(P<0.05). There was no statistical significance in observation group 5,7 d after surgery and control group 7 d after surgery,compared to before surgery and 7 d after surgery(P>0.05).One month after surgery,Lysholm scores of 2 groups were significantly higher than before surgery,and the observation group was significantly higher than the control group,with statistical significance(P<0.05). No severe ADR was found in 2 groups during medication,and there also was not deep venous thrombosis after surgery. CONCLUSIONS:Intra-articular injection of tranexamic acid can effectively reduce the degree of early knee swelling after knee arthroplasty,relieve postoperative early pain.It promotes the recovery of knee function with good safety.

【Objective】 To analyze the effects of three sterilization methods, namely, pressure steam, low-temperature plasma and ethylene oxide, on the magnetic flux of magnetic surgical devices and their sterilization costs. 【Methods】 A total of 234 magnetic surgical devices of different specifications and models (magnetic rings) were randomly divided into Group A, Group B and Group C after the paired number was labelled, and each group consisted of 78 pieces (39 pairs). After packaging each pair of devices according to sterilization specifications, Group A was sterilized by pressure steam, Group B was sterilized by low-temperature plasma, and Group C was sterilized by ethylene oxide. We measured the magnetic flux of three sets of magnetic rings before and after sterilization, and comparatively analyzed the sterilization cost and sterilization time of the single package. 【Results】 There was no statistically significant difference in the impact of the three sterilization methods on the magnetic flux of the magnetic surgical devices (P>0.05), but there was a significant difference in the magnetic flux before and after sterilization for each sterilization method (P<0.001); the sterilization cost was (1.96±0.16) yuan for Group A, (23.17±0.32) yuan for Group B, and (8.16±0.18) yuan for Group C, showing statistically significant differences among the three groups (P<0.01). The sterilization time was (65.21±3.36) min for Group A, (45.46±1.39) min for Group B, and (1020.38±12.21) min for Group C, with statistically significant differences among the three groups (P<0.01). 【Conclusion】 None of the three sterilization methods affects the magnetic flux of the magnetic surgical devices. Pressure steam method shows the lowest cost of single package, low-temperature plasma method shows the highest cost of single package, while ethylene oxide method shows the highest sterilization time. Pressure steam should be the preferred sterilization method for magnetic surgical devices.