Objective To evaluate the efficacy and safety of low?level laser therapy(LLLT)for androgenetic alopecia, and to compare the therapeutic effect of LLLT alone versus in combination with finasteride tablets. Methods Thirty?nine male patients were randomly divided into the LLLT group(n=21)and combination group(n=18)to be treated with LLLT alone or in combination with oral finasteride tablets(1 mg/d)for 6 months. LLLT was given twice a week, and each session lasted 30 minutes. All the patients were photographed and asked to fill a questionnaire about subjective symptoms, and hair density (the number of hairs per unit area on the scalp) was determined by using a dermatoscope to evaluate the grade of alopecia, before the treatment, and 3 and 6 months after the treatment. Results The hair density in the LLLT group was significantly higher after 6 months than after 3 months of treatment and before the treatment(184.59 ± 21.17 vs. 169.24 ± 29.21 and 166.67 ± 32.94 hairs/cm2, both P<0.05), but was insignificantly different between before and after 3 months of treatment (P > 0.05). The hair density in the combination group significantly increased after 6 and 3 months of treatment compared with that before the treatment(201.80 ± 16.55 and 186.39 ± 17.97 vs. 157.85 ± 27.97 hairs/cm2, both P < 0.05), and was significantly higher after 6 months than after 3 months of treatment(P<0.05). No significant difference was observed in hair density between the two groups before the treatment(P>0.05), but the combination group showed increased hair density compared with the LLLT group after 3 and 6 months of treatment(both P<0.05). After 6 months of treatment, LLLT alone was effective in 17 patients, but ineffective in 4 patients, and the combination therapy was effective in 16 patients, but ineffective in 2 patients, with no significant difference in the response rate between the LLLT group and combination group (χ2 = 0.057, P > 0.05). During the treatment, 24(62%)patients felt less greasy, and 22(56%)reported less hair loss, with no discomforts reported by the patients except local warm feeling. Conclusion LLLT is indeed effective for the treatment of androgenetic alopecia with no adverse reactions.

Objective:To observe the effect of hair care products containing zinc pyrithione, pollen extract, sachitin and other ingredients assisted with finasteride in the treatment of androgenic alopecia.Methods:From June 2018 to February 2019, 60 male androgen alopecia patients aged 18-40 (30.85±4.73) years were enrolled in this study. 30 cases in each group were treated for 180 days, and finasteride 1 mg/day was taken orally in both groups. In the experimental group, on the basis of finasteride, hair care products containing zinc pyrithione, pollen extract, sachitin and other ingredients were used, while the control group was treated with common care products. The improvement of scalp and hair and the satisfaction of patients were evaluated before and after treatment.Results:After 180 days of treatment, the improvement of scalp oil ( t=2.744, P<0.05), pruritus ( t=2.574, P<0.05), dandruff ( t=2.579, P<0.05) and general sense of use ( t=2.134, P<0.05) in the experimental group were significantly better than those in the control group ( t=2.077, P<0.05). The hair density of the experimental group was significantly better than that of the control group ( P<0.05). The patients＇ satisfaction rates in the experimental group and the control group were 96.67% (29/30) and 83.33% (25/30), respectively; there was no significant difference between the two groups ( P>0.05). No adverse reactions were found in all patients. Conclusions:Hair care products containing zinc pyrithione, pollen extract, sachitin and other ingredients assisted with finasteride can improve the scalp oil, pruritus and dandruff of patients with androgenic alopecia, and can increase the curative effect of the treatment of alopecia of the patients.

Objective To compare the long-term outcomes of partial hepatectomy versus choledocholithotomy both combined with choledochoscopy,for the treatment of hepatolithiasis.Methods Patients who underwent either type of the operations were followed up and examined using hepatobiliary magnetic resonance (enhanced MRI + MRCP).The incidences of abnormal imaging in the two groups were compared.Results Of 268 patients,138 patients underwent partial hepatectomy and the remaining 130 patients underwent choledocholithotomy.When hepatectomy was compared with choledocholithotomy,the recurrence rate of acute cholangitis combined with bile duct stone (5.8％ vs.21.5％),the reoperation rate (5.8％ vs.21.5％),the bile duct stricture rate (8.0％ vs.44.6％),the abnormal liver parenchyma perfusion rate (4.3％ vs.23.1％),the incidence of intrahepatic bile duct enhancement or thickening (1.5％ vs.26.9％),the incidence of hepatic atrophy (3.0％ vs.30.0％) and the incidence of cholangiocarcinoma (0 vs.2.3％) were better.Conclusions The long-term adverse outcomes were significantly worse in the choledocholithotomy group than in the partial hepatectomy group.Choledocholithotomy combined with choledochoscopy should only be considered as a complementary procedure to partial hepatectomy in hepatolithiasis.

Objective:To study the clinical effect of alpha hydroxy acids on facial acne patients.Methods:A total of 36 patients with facial acne who were treated at the Department of Dermatology, Beijing Friendship Hospital from December 1, 2018 to May 31, 2019 were selected. All patients were treated with 20% alpha hydroxy acids. Treatment efficiency, lesions improvement and patients＇satisfaction were evaluated.Results:All evaluation indexes were improved after treatment. Before treatment, patients with acne were classified into grade Ⅰ(9 cases), grade Ⅱ(18 cases ), and grade Ⅲ (9 cases) through Pillsbury Grading, and after treatment, there were 28 cases of grade Ⅰ, 28 cases of grade Ⅱ, and 0 cases of grade Ⅲ, which had statistic differences ( χ2= 22.603, P<0.001). The number of lesions before treatment was 38.64±15.57, and that was 16.17±11.49 after treatment, and the difference was statistically significant ( t=6.967, P<0.001). After treatment, 2 cases were cured, 17 cases were markedly effective, 11 cases were effective, 2 cases were ineffective and 4 cases were worsening. 30 patients were cured, markedly effective or effective, and the total effective rate was 83.33%. The value of skin pores before treatment was 1263.67±593.44, and decreased to 1196.33±579.27 after treatment. The difference was statistically significant ( t=3.155, P<0.05). After the treatment, all the patients were satisfied with the effect. Conclusions:Alpha hydroxy acid is a safe and effective method for acne patients.