1.Review and prospect of National Natural Science Foundation of China funded in lung cancer project from 2006 to 2015
Feng ZHOU ; Dongliang BIAN ; Fenghuan SUN ; Gening JIANG ; Peng ZHANG
Chinese Journal of Thoracic and Cardiovascular Surgery 2018;34(7):441-446
National investment in lung cancer related research projects increased during the past few years , the funding from National Natural Science Foundation of China(NSFC) also have an upward trend year by year.As the statistical analysis shows, the NSFC devoted a lot to the projects of lung cancer in both numbers and amounts from 2006 to 2015, and grows rapid-ly.General projects and youth fund projects are predominant types of funds; medical science department is the majority of all departments; Hot research projects include MicroRNA, EMT, lung cancer stem cell, apoptosis, lung cancer genomics,angio-genesis of lung cancer,EGFR, lncRNA, Wnt pathway, etc.The autophagy、lncRNA and Wnt pathway related researchs have gone through the process from scratch, and investments have continued to increase.The purpose of this study is to analyze the distribution and hotspot research of NSFC funded projects in the field of lung cancer in China.
2.Construction and Application of Evaluation Index System for Clinical Specialty Capability of Traditional Chinese Medicine in Shandong Province
Jingjing LUO ; Fanyu MENG ; Chengchao ZHOU ; Peilong LI ; Yuehan WANG ; Tianzheng LIU ; Fenghuan CUI ; Xin ZHANG ; Mengyuan LI ; Jingjie SUN
Chinese Hospital Management 2023;43(12):35-38
Objective Construct a scientific and reasonable evaluation index system for clinical specialties of tradi-tional Chinese medicine in Shandong Province to provide a scientific basis for improving the service capacity of clini-cal specia lties of traditional Chinese medicine.Methods Based on relevant policies and literature research,the analytic hierarchy process and Delphi expert consultation method were used to determine the index system and its weight,and 509 clinical specialties of traditional Chinese medicine capacity levels of 178 medical institutions in Shandong Province were evaluated.Results A scientific and effective evaluation index system for clinical specialty capacity of traditional Chinese medicine in Shandong Province was constructed,with 23 secondary indicators in 5 dimen-sions.It comprehensively evaluats the service capacity and management level of orthopedics and traumatology de-partments of traditional Chinese medicine class hospitals in Shandong Province,uses orthopedics and traumatology as an example.Conclusion Driven by the dynamic monitoring of the evaluation index system,improve the service ca-pacity for clinical specialties of traditional Chinese medicine,guide it to strengthen the internal construction of tradi-tional Chinese medicine,and give full play to the advantages of traditional Chinese medicine characteristics.Increase the support for clinical specialties of traditional Chinese medicine in Shandong Province,and then promote the high-quality development of traditional Chinese medicine.
3. Efficacy of bare metal stent for treating focal coronary artery aneurysm complicating with severe stenosis in single coronary artery
Shubin QIAO ; Jia LI ; Jingang CUI ; Jiansong YUAN ; Shengwen LIU ; Jie ZHAO ; Fenghuan HU ; Weixian YANG ; Haibo LIU ; Zhongwei SUN ; Runlin GAO
Chinese Journal of Cardiology 2018;46(4):279-283
Objective:
To investigate the efficacy of bare metal stent for treating focal coronary artery aneurysm complicating with severe stenosisin single coronary artery.
Methods:
This retrospective analysis was performed in 7 patients who were diagnosed as local coronary artery aneurysm complicating with severe stenosis(≥70%) in single coronary artery and treated with bare metal stent during the period from December 2012 to June 2015 in Fuwai Hospital. All 7 patients were male with age of (62±11) years old. During the interventional operation, the narrow parts were pre-expanded,and all patients received bare metal stents implantation to cover aneurysms.The clinical and imaging data of patients immediately post procedure and at postoperative follow-up were collected to evaluate the clinical efficacy.
Results:
There were 5 cases of left anterior descending aneurysms and 2 cases of right coronary artery aneurysms. The diameter of aneurysm was (5.21±1.28)mm, and the length was (13.71±3.88)mm. There was intracranial vortex in coronary arteriography immediately after intervention.Proximalstenosis of coronary artery aneurysm was disappeared,and the distal blood flow was TIMI class 3.There were no signs of aortic dissection and thrombus formation.During 6(6 16) months follow-up, the aneurysms were disappeared,and there were no major adverse cardiovascular events which including myocardial ischemia, acute myocardial infarction, revascularization,bleeding,and death for all patients.
Conclusion
Initial experience shows that double-layer bare metal stents implantation for patients with localized coronary artery aneurysm complicating with severe stenosis in single vessel is safe and effective.
4.Neoadjuvant chemoimmunotherapy combined with surgery for patients with non-small-cell lung cancer staged as ⅢA
Fenghuan SUN ; Jie YANG ; Tao GE ; Haoran XIA ; Jie DAI ; Xiaogang LIU ; Jiaqi LI ; Likun HOU ; Liang DUAN ; Chunyan WU ; Yuming ZHU ; Gening JIANG ; Peng ZHANG
Chinese Journal of Thoracic and Cardiovascular Surgery 2021;37(9):516-520
Objective:To explore the efficacy and safety of neoadjuvant chemoimmunotherapy combined with surgery for stage ⅢA NSCLC patients.Methods:Six patients with NSCLC who were diagnosed as ⅢA and received two cycles of neoadjuvant chemoimmunotherapy and surgery between September 2019 and January 2020 were described in this study.Results:Five of them experienced AEs during neoadjuvant therapy. All of them received surgery and achieved an MPR of 50%. No viable tumor cells were found in the tissues of one patient. One patient with a small bronchopleural fistula after lobectomy.Conclusion:Neoadjuvant chemoimmunotherapy combined with surgery for stage ⅢA NSCLC patients is safe and efficient. Long-term outcomes of neoadjuvant chemoimmunotherapy combined with surgery should be further validated.